Literature DB >> 28465625

New chlorinated xanthone and anthraquinone produced by a mangrove-derived fungus Penicillium citrinum HL-5126.

Ke-Yao He1, Cheng Zhang1, Yi-Ru Duan1, Guo-Lei Huang1, Chun-Yan Yang1, Xing-Rui Lu1, Cai-Juan Zheng1, Guang-Ying Chen1.   

Abstract

Two new chlorinated metabolites 4-chloro-1-hydroxy-3-methoxy-6-methyl-8-methoxycarbonyl-xanthen-9-one (1) and 2'-acetoxy-7-chlorocitreorosein (2), together with three known compounds (3-5), were obtained from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were evaluated for their antibacterial and topoisomerase I inhibitory activities. Compound 2 exhibited antibacterial activity against Vibrio parahaemolyticus with an MIC value of 10 μm.

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Year:  2017        PMID： 28465625     DOI： 10.1038/ja.2017.52

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  14 in total

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Authors:  W L Ma; C Y Yan; J H Zhu; G Y Duan; R M Yu
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Authors:  Guo-Lei Huang; Xue-Ming Zhou; Meng Bai; Yu-Xin Liu; Yan-Lei Zhao; You-Ping Luo; Yan-Yan Niu; Cai-Juan Zheng; Guang-Ying Chen
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  9 in total

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4.  Lichen Xanthones as Models for New Antifungal Agents.

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Journal:  Molecules       Date:  2018-10-12       Impact factor: 4.411

Review 5.  A Review: Halogenated Compounds from Marine Fungi.

Authors:  Cong Wang; Huanyun Lu; Jianzhou Lan; K H Ahammad Uz Zaman; Shugeng Cao
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Review 6.  Marine Pharmacology in 2016-2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

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7.  Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6.

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Review 9.  Chemical diversity, medicinal potentialities, biosynthesis, and pharmacokinetics of anthraquinones and their congeners derived from marine fungi: a comprehensive update.

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  9 in total

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