| Literature DB >> 22703109 |
Hongbo Huang1, Fazuo Wang, Minghe Luo, Yuchan Chen, Yongxiang Song, Weimin Zhang, Si Zhang, Jianhua Ju.
Abstract
Metabolomic investigations focusing on the marine-derived fungus Aspergillus sp. SCSIO F063 have unveiled seven new chlorinated anthraquinones (1-7) related to averantin, together with five known analogues (11-15) when the fungus was fermented using sea salt-containing potato dextrose broth. Through the addition of sodium bromide to the broth, two new brominated anthraquinones (8, 9) and one new nonhalogenated anthraquinone (10) were obtained from the fungal mycelia. Their structures were elucidated by extensive spectroscopic analyses including MS and 1D and 2D NMR data. One metabolite, 6-O-methyl-7-chloroaveratin (2), displayed inhibition activity against three human tumor cell lines, SF-268, MCF-7, and NCI-H460, with IC(50) values of 7.11, 6.64, and 7.42 μM, respectively.Entities:
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Year: 2012 PMID： 22703109 DOI： 10.1021/np3002699
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050