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Literature DB >> 2846399

Gastrin receptors in human gastric scirrhous carcinoma.

Abstract

Specific binding of 125I-labeled gastrin-17 in tumor tissues and gastric mucosa of 11 advanced human gastric carcinoma cases were studied by single-point receptor assay, using 400 pM 125I-labeled gastrin-17. Membrane preparations (800-15,000 g fraction) of the tissues were examined in this study. In 4 of the 5 cases of gastric scirrhous carcinoma (Borrmann type IV), the tumor tissues showed a high degree of specific bindings (1.1-18.2 femtomoles per milligram protein), but in 5 of the 6 cases of Borrmann type II or III, no specific bindings were detected. These findings indicate that gastrin receptor is frequently present in human gastric scirrhous carcinoma.

Entities: Chemical Disease Gene Species

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Year: 1988 PMID： 2846399 DOI： 10.1007/bf02779205

Source DB: PubMed Journal: Gastroenterol Jpn ISSN： 0435-1339

18 in total

1. Mucosal gastrin receptor. I. Assay standardization and fulfillment of receptor criteria.

Authors: K Takeuchi; G R Speir; L R Johnson
Journal: Am J Physiol Date: 1979-09

2. Gastric carcinoma in dogs produced by the combined use of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and gastrin--with special reference to development of scirrhous carcinoma.

Authors: M Kurihara; H Shirakabe; F Yamaya; K Miyasaka; T Maruyama; T Izumi; A Yasui; T Kamano
Journal: Acta Pathol Jpn Date: 1979-03

3. Effect of pentagastrin on adult rat duodenal cells in culture.

Authors: L Lichtenberger; L R Miller; D N Erwin; L R Johnson
Journal: Gastroenterology Date: 1973-08 Impact factor: 22.682

4. Effect of gastro-entero-pancreatic endocrine hormones on the histogenesis of gastric cancer in rats induced by N-methyl-N'-nitro-N-nitrosoguanidine; with special reference to development of scirrhous gastric cancer.

Authors: E Tahara; S Haizuka
Journal: Gan Date: 1975-08

5. A specific gastrin receptor in human gastric mucosa.

Authors: T Tokunaga; A Misumi; M Akagi
Journal: Gastroenterol Jpn Date: 1984-02

6. Effects of gastrin on tumor growth and cyclic nucleotide metabolism in xenotransplantable human gastric and colonic carcinomas in nude mice.

Authors: H Sumiyoshi; W Yasui; A Ochiai; E Tahara
Journal: Cancer Res Date: 1984-10 Impact factor: 12.701

7. Effects of gastrointestinal hormones on pancreatic growth.

Authors: L R Johnson
Journal: Cancer Date: 1981-03-15 Impact factor: 6.860

8. Trophic effects of gastrin on colorectal neoplasms in the rat.

Authors: D B McGregor; R D Jones; D A Karlin; M M Romsdahl
Journal: Ann Surg Date: 1982-02 Impact factor: 12.969

9. Effect of prolonged administration of gastrin on experimental carcinogenesis in rat colon induced by intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine.

Authors: M Tatsuta; H Yamamura; M Ichii; H Taniguchi
Journal: Cancer Res Date: 1983-05 Impact factor: 12.701

Gastrin receptors in human gastric scirrhous carcinoma.

1. Mucosal gastrin receptor. I. Assay standardization and fulfillment of receptor criteria.

2. Gastric carcinoma in dogs produced by the combined use of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and gastrin--with special reference to development of scirrhous carcinoma.

3. Effect of pentagastrin on adult rat duodenal cells in culture.

4. Effect of gastro-entero-pancreatic endocrine hormones on the histogenesis of gastric cancer in rats induced by N-methyl-N'-nitro-N-nitrosoguanidine; with special reference to development of scirrhous gastric cancer.

5. A specific gastrin receptor in human gastric mucosa.

6. Effects of gastrin on tumor growth and cyclic nucleotide metabolism in xenotransplantable human gastric and colonic carcinomas in nude mice.

7. Effects of gastrointestinal hormones on pancreatic growth.

8. Trophic effects of gastrin on colorectal neoplasms in the rat.

9. Effect of prolonged administration of gastrin on experimental carcinogenesis in rat colon induced by intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine.

10. Changes in protein and nucleic acid synthesis in rat gastric mucosa after pentagastrin.

Review 1. Growth factors and oncogenes in human gastrointestinal carcinomas.

Review 2. Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach.

Review 3. Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal disorders.

4. Gastrin receptors in the human gastrointestinal tract and pancreas.

Review 5. Characteristics and Early Diagnosis of Gastric Cancer Discovered after Helicobacter pylori Eradication.

6. Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradiation therapy.