Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Gastrin receptors in the human gastrointestinal tract and pancreas.

Literature DB >> 2744328

Gastrin receptors in the human gastrointestinal tract and pancreas.

T Kumamoto¹, K Sumii, K Haruma, A Tari, K Tanaka, G Kajiyama.

Abstract

The specific binding of 125I-labeled gastrin-17 was studied in samples of human gastric mucosa, duodenal mucosa, colonic mucosa or pancreatic tissue obtained surgically. With regard to gastric fundic mucosa, the criteria for receptor binding were studied, and saturability, high affinity, tissue specificity and hormone specificity were demonstrated. The dissociation constant for gastric fundic mucosa was 1.6 X 10(-9)M, and the binding capacity was 15 fmol/mg protein. Tissue specificity studies revealed a high degree of gastrin receptor binding in human gastric fundic mucosa, duodenal mucosa and pancreas, whereas antral mucosa and colonic mucosa demonstrated a low degree of binding.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2744328 DOI： 10.1007/bf02774183

Source DB: PubMed Journal: Gastroenterol Jpn ISSN： 0435-1339

22 in total

1. Mucosal gastrin receptor. I. Assay standardization and fulfillment of receptor criteria.

Authors: K Takeuchi; G R Speir; L R Johnson
Journal: Am J Physiol Date: 1979-09

2. Localization of gastrin receptors in intact isolated and separated rat fundic cells.

Authors: A Soumarmon; A M Cheret; M J Lewin
Journal: Gastroenterology Date: 1977-10 Impact factor: 22.682

3. Parietal and chief cell populations in four cases of the Zollinger-Ellison syndrome.

Authors: P Neuburger; M Lewin; C de Recherche; S Bonfils
Journal: Gastroenterology Date: 1972-12 Impact factor: 22.682

4. Effect of pentagastrin on adult rat duodenal cells in culture.

Authors: L Lichtenberger; L R Miller; D N Erwin; L R Johnson
Journal: Gastroenterology Date: 1973-08 Impact factor: 22.682

5. Influence of chronic administration of pentagastrin on the pancreas in hypophysectomized rats.

Authors: P D Mayston; J A Barrowman
Journal: Gastroenterology Date: 1973-03 Impact factor: 22.682

6. Radioautographic and quantitative studies on parietal and peptic cell kinetics in the mouse. A selective effect of gastrin on parietal cell proliferation.

Authors: G Willems; T Lehy
Journal: Gastroenterology Date: 1975-08 Impact factor: 22.682

Gastrin receptors in the human gastrointestinal tract and pancreas.

1. Mucosal gastrin receptor. I. Assay standardization and fulfillment of receptor criteria.

2. Localization of gastrin receptors in intact isolated and separated rat fundic cells.

3. Parietal and chief cell populations in four cases of the Zollinger-Ellison syndrome.

4. Effect of pentagastrin on adult rat duodenal cells in culture.

5. Influence of chronic administration of pentagastrin on the pancreas in hypophysectomized rats.

6. Radioautographic and quantitative studies on parietal and peptic cell kinetics in the mouse. A selective effect of gastrin on parietal cell proliferation.

7. Effect of gastrin on gastric mucosal cell proliferation in man.

8. Gastrin receptors on isolated canine parietal cells.

9. Effects of gastrointestinal hormones on pancreatic growth.

10. Changes in protein and nucleic acid synthesis in rat gastric mucosa after pentagastrin.

1. High expression of gastrin receptor protein in injured mucosa of Helicobacter pylori-positive gastritis.

2. Expression of receptors for gut peptides in human pancreatic adenocarcinoma and tumour-free pancreas.