Literature DB >> 28462811

Sphingolipids and Lipoproteins in Health and Metabolic Disorders.

Jahangir Iqbal1, Meghan T Walsh2, Samar M Hammad3, M Mahmood Hussain4.   

Abstract

Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and plasma lipoproteins. The cellular and plasma concentrations of sphingolipids are altered in several metabolic disorders and may serve as prognostic and diagnostic markers. Here we discuss various sphingolipid transport mechanisms and highlight how changes in cellular and plasma sphingolipid levels contribute to cardiovascular disease, obesity, diabetes, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). Understanding of the mechanisms involved in intracellular transport, secretion, and extracellular transport may provide novel information that might be amenable to therapeutic targeting for the treatment of various metabolic disorders.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  MTP; ceramide; lipoproteins; metabolic disorders; sphingolipids; sphingomyelin

Mesh：

Substances：

Year:  2017        PMID： 28462811      PMCID： PMC5474131          DOI： 10.1016/j.tem.2017.03.005

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  86 in total

1.  Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.

Authors:  William L Holland; Benjamin T Bikman; Li-Ping Wang; Guan Yuguang; Katherine M Sargent; Sarada Bulchand; Trina A Knotts; Guanghou Shui; Deborah J Clegg; Markus R Wenk; Michael J Pagliassotti; Philipp E Scherer; Scott A Summers
Journal:  J Clin Invest       Date:  2011-04-01       Impact factor: 14.808

2.  Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities.

Authors:  Laurent Camont; Marie Lhomme; Fabiana Rached; Wilfried Le Goff; Anne Nègre-Salvayre; Robert Salvayre; Catherine Calzada; Michel Lagarde; M John Chapman; Anatol Kontush
Journal:  Arterioscler Thromb Vasc Biol       Date:  2013-10-03       Impact factor: 8.311

3.  Gene expression in human NAFLD.

Authors:  Dario Greco; Anna Kotronen; Jukka Westerbacka; Oscar Puig; Perttu Arkkila; Tuula Kiviluoto; Saara Laitinen; Maria Kolak; Rachel M Fisher; Anders Hamsten; Petri Auvinen; Hannele Yki-Järvinen
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2008-04-03       Impact factor: 4.052

4.  Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

Authors:  Sarah M Turpin; Hayley T Nicholls; Diana M Willmes; Arnaud Mourier; Susanne Brodesser; Claudia M Wunderlich; Jan Mauer; Elaine Xu; Philipp Hammerschmidt; Hella S Brönneke; Aleksandra Trifunovic; Giuseppe LoSasso; F Thomas Wunderlich; Jan-Wilhelm Kornfeld; Matthias Blüher; Martin Krönke; Jens C Brüning
Journal:  Cell Metab       Date:  2014-10-07       Impact factor: 27.287

Review 5.  Sources, metabolism, and regulation of circulating sphingosine-1-phosphate.

Authors:  Monika Książek; Marta Chacińska; Adrian Chabowski; Marcin Baranowski
Journal:  J Lipid Res       Date:  2015-05-26       Impact factor: 5.922

Review 6.  Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis.

Authors:  Linda Sasset; Yi Zhang; Teresa M Dunn; Annarita Di Lorenzo
Journal:  Trends Endocrinol Metab       Date:  2016-08-22       Impact factor: 12.015

7.  Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate.

Authors:  Rajita Pappu; Susan R Schwab; Ivo Cornelissen; João P Pereira; Jean B Regard; Ying Xu; Eric Camerer; Yao-Wu Zheng; Yong Huang; Jason G Cyster; Shaun R Coughlin
Journal:  Science       Date:  2007-03-15       Impact factor: 47.728

8.  Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice.

Authors:  Elias N Glaros; Woojin S Kim; Kerry-Anne Rye; James A Shayman; Brett Garner
Journal:  J Lipid Res       Date:  2008-05-08       Impact factor: 5.922

9.  ApoA-I induces a preferential efflux of monounsaturated phosphatidylcholine and medium chain sphingomyelin species from a cellular pool distinct from HDL(3) mediated phospholipid efflux.

Authors:  Rainer Schifferer; Gerhard Liebisch; Sascha Bandulik; Thomas Langmann; Ashraf Dada; Gerd Schmitz
Journal:  Biochim Biophys Acta       Date:  2007-04-24

10.  Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network.

Authors:  Masayuki Nagahashi; Eugene Y Kim; Akimitsu Yamada; Subramaniam Ramachandran; Jeremy C Allegood; Nitai C Hait; Michael Maceyka; Sheldon Milstien; Kazuaki Takabe; Sarah Spiegel
Journal:  FASEB J       Date:  2012-11-24       Impact factor: 5.191
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  57 in total

1.  Rare DEGS1 variant significantly alters de novo ceramide synthesis pathway.

Authors:  Nicholas B Blackburn; Laura F Michael; Peter J Meikle; Juan M Peralta; Marian Mosior; Scott McAhren; Hai H Bui; Melissa A Bellinger; Corey Giles; Satish Kumar; Ana C Leandro; Marcio Almeida; Jacquelyn M Weir; Michael C Mahaney; Thomas D Dyer; Laura Almasy; John L VandeBerg; Sarah Williams-Blangero; David C Glahn; Ravindranath Duggirala; Mark Kowala; John Blangero; Joanne E Curran
Journal:  J Lipid Res       Date:  2019-06-21       Impact factor: 5.922

2.  Plasma metabolomics exhibit response to therapy in chronic thromboembolic pulmonary hypertension.

Authors:  Emilia M Swietlik; Pavandeep Ghataorhe; Kasia I Zalewska; John Wharton; Luke S Howard; Dolores Taboada; John E Cannon; Nicholas W Morrell; Martin R Wilkins; Mark Toshner; Joanna Pepke-Zaba; Christopher J Rhodes
Journal:  Eur Respir J       Date:  2021-04-01       Impact factor: 16.671

Review 3.  Cardiovascular Implications of Sphingomyelin Presence in Biological Membranes.

Authors:  Petros Kikas; George Chalikias; Dimitrios Tziakas
Journal:  Eur Cardiol       Date:  2018-08

4.  Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.

Authors:  Weiwei Dai; William P Miller; Allyson L Toro; Adam J Black; Sadie K Dierschke; Robert P Feehan; Scot R Kimball; Michael D Dennis
Journal:  FASEB J       Date:  2018-06-19       Impact factor: 5.191

5.  Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases.

Authors:  Museer A Lone; Andreas J Hülsmeier; Essa M Saied; Gergely Karsai; Christoph Arenz; Arnold von Eckardstein; Thorsten Hornemann
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-23       Impact factor: 11.205

6.  Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome.

Authors:  Bing Peng; Sascha Geue; Cristina Coman; Patrick Münzer; Dominik Kopczynski; Canan Has; Nils Hoffmann; Mailin-Christin Manke; Florian Lang; Albert Sickmann; Meinrad Gawaz; Oliver Borst; Robert Ahrends
Journal:  Blood       Date:  2018-05-21       Impact factor: 22.113

7.  ATP binding cassette family A protein 1 determines hexosylceramide and sphingomyelin levels in human and mouse plasma.

Authors:  Jahangir Iqbal; Meghan T Walsh; Samar M Hammad; Marina Cuchel; Daniel J Rader; M Mahmood Hussain
Journal:  J Lipid Res       Date:  2018-10-02       Impact factor: 5.922

8.  A Pilot Study of Serum Sphingomyelin Dynamics in Subjects with Severe Obesity and Non-alcoholic Steatohepatitis after Sleeve Gastrectomy.

Authors:  Bruno Ramos-Molina; Daniel Castellano-Castillo; Oscar Pastor; Luis Ocaña-Wilhelmi; Diego Fernández-García; Manuel Romero-Gómez; Fernando Cardona; Francisco J Tinahones
Journal:  Obes Surg       Date:  2019-03       Impact factor: 4.129

9.  Serum sphingolipids and incident diabetes in a US population with high diabetes burden: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Authors:  Guo-Chong Chen; Jin Choul Chai; Bing Yu; Gregory A Michelotti; Megan L Grove; Amanda M Fretts; Martha L Daviglus; Olga L Garcia-Bedoya; Bharat Thyagarajan; Neil Schneiderman; Jianwen Cai; Robert C Kaplan; Eric Boerwinkle; Qibin Qi
Journal:  Am J Clin Nutr       Date:  2020-07-01       Impact factor: 7.045

Review 10.  Role of sphingolipids in senescence: implication in aging and age-related diseases.

Authors:  Magali Trayssac; Yusuf A Hannun; Lina M Obeid
Journal:  J Clin Invest       Date:  2018-07-02       Impact factor: 14.808
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