Literature DB >> 28461478

Sequential allosteric mechanism of ATP hydrolysis by the CCT/TRiC chaperone is revealed through Arrhenius analysis.

Ranit Gruber1, Michael Levitt2, Amnon Horovitz3.   

Abstract

Knowing the mechanism of allosteric switching is important for understanding how molecular machines work. The CCT/TRiC chaperonin nanomachine undergoes ATP-driven conformational changes that are crucial for its folding function. Here, we demonstrate that insight into its allosteric mechanism of ATP hydrolysis can be achieved by Arrhenius analysis. Our results show that ATP hydrolysis triggers sequential ‟conformational waves." They also suggest that these waves start from subunits CCT6 and CCT8 (or CCT3 and CCT6) and proceed clockwise and counterclockwise, respectively.

Entities:  

Keywords:  allostery; chaperonins; conformational changes; molecular machines

Mesh：

Substances：

Year:  2017        PMID： 28461478      PMCID： PMC5441784          DOI： 10.1073/pnas.1617746114

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

Review 1.  Chaperone rings in protein folding and degradation.

Authors:  A L Horwich; E U Weber-Ban; D Finley
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

Review 2.  Allosteric Mechanisms in Chaperonin Machines.

Authors:  Ranit Gruber; Amnon Horovitz
Journal:  Chem Rev       Date:  2016-01-04       Impact factor: 60.622

3.  Sequential ATP-induced allosteric transitions of the cytoplasmic chaperonin containing TCP-1 revealed by EM analysis.

Authors:  Dalia Rivenzon-Segal; Sharon G Wolf; Liat Shimon; Keith R Willison; Amnon Horovitz
Journal:  Nat Struct Mol Biol       Date:  2005-02-06       Impact factor: 15.369

4.  The interaction network of the chaperonin CCT.

Authors:  Carien Dekker; Peter C Stirling; Elizabeth A McCormack; Heather Filmore; Angela Paul; Renee L Brost; Michael Costanzo; Charles Boone; Michel R Leroux; Keith R Willison
Journal:  EMBO J       Date:  2008-05-29       Impact factor: 11.598

5.  Equivalent mutations in the eight subunits of the chaperonin CCT produce dramatically different cellular and gene expression phenotypes.

Authors:  Maya Amit; Sarah J Weisberg; Michal Nadler-Holly; Elizabeth A McCormack; Ester Feldmesser; Daniel Kaganovich; Keith R Willison; Amnon Horovitz
Journal:  J Mol Biol       Date:  2010-06-25       Impact factor: 5.469

6.  Sensing cooperativity in ATP hydrolysis for single multisubunit enzymes in solution.

Authors:  Yan Jiang; Nicholai R Douglas; Nicholas R Conley; Erik J Miller; Judith Frydman; W E Moerner
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-06       Impact factor: 11.205

7.  Direct, real-time measurement of rapid inorganic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase.

Authors:  M Brune; J L Hunter; J E Corrie; M R Webb
Journal:  Biochemistry       Date:  1994-07-12       Impact factor: 3.162

8.  Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.

Authors:  Oksana A Sergeeva; Bo Chen; Cameron Haase-Pettingell; Steven J Ludtke; Wah Chiu; Jonathan A King
Journal:  J Biol Chem       Date:  2013-04-23       Impact factor: 5.157

9.  Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX.

Authors:  Benjamin M Stinson; Vladimir Baytshtok; Karl R Schmitz; Tania A Baker; Robert T Sauer
Journal:  Nat Struct Mol Biol       Date:  2015-04-13       Impact factor: 15.369

10.  Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies.

Authors:  Alice Y Yam; Yu Xia; Hen-Tzu Jill Lin; Alma Burlingame; Mark Gerstein; Judith Frydman
Journal:  Nat Struct Mol Biol       Date:  2008-11-16       Impact factor: 15.369
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  12 in total

Review 1.  The substrate specificity of eukaryotic cytosolic chaperonin CCT.

Authors:  Keith R Willison
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-06-19       Impact factor: 6.237

Review 2.  Unpicking allosteric mechanisms of homo-oligomeric proteins by determining their successive ligand binding constants.

Authors:  Ranit Gruber; Amnon Horovitz
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-06-19       Impact factor: 6.237

Review 3.  Molecular switch-like regulation in motor proteins.

Authors:  Sara Tafoya; Carlos Bustamante
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-06-19       Impact factor: 6.237

Review 4.  Intrinsic dynamics is evolutionarily optimized to enable allosteric behavior.

Authors:  Yan Zhang; Pemra Doruker; Burak Kaynak; She Zhang; James Krieger; Hongchun Li; Ivet Bahar
Journal:  Curr Opin Struct Biol       Date:  2019-11-27       Impact factor: 6.809

5.  Intraring allostery controls the function and assembly of a hetero-oligomeric class II chaperonin.

Authors:  Deborah K Shoemark; Richard B Sessions; Andrea Brancaccio; Maria Giulia Bigotti
Journal:  FASEB J       Date:  2018-01-05       Impact factor: 5.191

Review 6.  The role of the molecular chaperone CCT in protein folding and mediation of cytoskeleton-associated processes: implications for cancer cell biology.

Authors:  Josefine Vallin; Julie Grantham
Journal:  Cell Stress Chaperones       Date:  2018-12-01       Impact factor: 3.667

7.  Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin.

Authors:  Yacob Gomez-Llorente; Fady Jebara; Malay Patra; Radhika Malik; Shahar Nisemblat; Orna Chomsky-Hecht; Avital Parnas; Abdussalam Azem; Joel A Hirsch; Iban Ubarretxena-Belandia
Journal:  Nat Commun       Date:  2020-04-21       Impact factor: 14.919

8.  Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells.

Authors:  Khanti Rattanapornsompong; Janya Khattiya; Phatchariya Phannasil; Narumon Phaonakrop; Sittiruk Roytrakul; Sarawut Jitrapakdee; Chareeporn Akekawatchai
Journal:  Biochem Biophys Rep       Date:  2021-01-12

9.  State-dependent sequential allostery exhibited by chaperonin TRiC/CCT revealed by network analysis of Cryo-EM maps.

Authors:  Yan Zhang; James Krieger; Karolina Mikulska-Ruminska; Burak Kaynak; Carlos Oscar S Sorzano; José-María Carazo; Jianhua Xing; Ivet Bahar
Journal:  Prog Biophys Mol Biol       Date:  2020-08-28       Impact factor: 3.667

10.  An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.

Authors:  Mingliang Jin; Wenyu Han; Caixuan Liu; Yunxiang Zang; Jiawei Li; Fangfang Wang; Yanxing Wang; Yao Cong
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-06       Impact factor: 11.205
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