Literature DB >> 2845968

Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats.

Y Naitoh1, J Fukata, T Tominaga, Y Nakai, S Tamai, K Mori, H Imura.   

Abstract

In order to assess the effect of interleukin-6 on the hypothalamo-pituitary-adrenal axis, we administered recombinant human interleukin-6 to conscious, freely-moving rats. The intravenous injection of interleukin-6 significantly increased the plasma level of adrenocorticotropic hormone 30 min after the injection in a dose-related manner. Immunoneutralization of corticotropin-releasing hormone blocked the stimulatory effects of interleukin-6 on adrenocorticotropic hormone secretion. These observations suggest that interleukin-6 stimulates the secretion of adrenocorticotropic hormone through the corticotropin-releasing hormone and is possibly involved in the interaction between the neuroendocrine and immune system.

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Year:  1988        PMID： 2845968     DOI： 10.1016/s0006-291x(88)81305-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  54 in total

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2.  On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion.

Authors:  A Ray; K S LaForge; P B Sehgal
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3.  Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1.

Authors:  A Ericsson; C Arias; P E Sawchenko
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Review 4.  Interleukins and neurohormones: a common language.

Authors:  R Knight; N Sarlis; A Stephanou
Journal:  Postgrad Med J       Date:  1992-08       Impact factor: 2.401

Review 5.  Interleukin-6 and the acute phase response.

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Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

6.  Interleukin-6 and interleukin-6 receptor gene expression in pituitary tumors.

Authors:  A R Rezai; A Rezai; O Martínez-Maza; M Vander-Meyden; M H Weiss
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

7.  Corticotropin-releasing hormone regulates IL-6 expression during inflammation.

Authors:  M Venihaki; P Dikkes; A Carrigan; K P Karalis
Journal:  J Clin Invest       Date:  2001-10       Impact factor: 14.808

8.  Interleukin-6 stimulates cell proliferation of rat pituitary clonal cell lines in vitro.

Authors:  T Sawada; K Koike; Y Kanda; H Ikegami; H Jikihara; T Maeda; Y Osako; K Hirota; A Miyake
Journal:  J Endocrinol Invest       Date:  1995-02       Impact factor: 4.256

9.  Effects of pyrogenic immunomodulators on the release of corticotrophin-releasing factor-41 and prostaglandin E2 from the intact rat hypothalamus in vitro.

Authors:  N G Milton; C H Self; E W Hillhouse
Journal:  Br J Pharmacol       Date:  1993-05       Impact factor: 8.739

Review 10.  Host defense against infections and inflammations: role of the multifunctional IL-6/IFN-beta 2 cytokine.

Authors:  M Revel
Journal:  Experientia       Date:  1989-06-15
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