Literature DB >> 28459108

CACHEXIA & BROWN FAT: A BURNING ISSUE IN CANCER.

Serkan Kir1, Bruce M Spiegelman1.   

Abstract

Cachexia, a progressive weight loss in cancer patients that results from tumor-induced energy wasting, is a serious problem that interferes with response to treatment and affects quality of life. Recent studies suggest that thermogenesis of adipose tissues is involved in energy wasting and also point to a link between the atrophy of fat and muscle. Tumor-derived PTHrP has emerged as a key molecule playing multiple roles in cachexia, from fat "browning" factor to potential therapeutic target.

Entities:  

Keywords:  Cancer cachexia; adipose tissue; browning; skeletal muscle atrophy; thermogenesis

Mesh：

Year:  2016        PMID： 28459108      PMCID： PMC5407404          DOI： 10.1016/j.trecan.2016.07.005

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  16 in total

1.  Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.

Authors:  Serkan Kir; James P White; Sandra Kleiner; Lawrence Kazak; Paul Cohen; Vickie E Baracos; Bruce M Spiegelman
Journal:  Nature       Date:  2014-07-13       Impact factor: 49.962

2.  Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice.

Authors:  Maria Tsoli; Melissa Moore; Dominic Burg; Arran Painter; Ryland Taylor; Sarah H Lockie; Nigel Turner; Alessandra Warren; Greg Cooney; Brian Oldfield; Stephen Clarke; Graham Robertson
Journal:  Cancer Res       Date:  2012-06-19       Impact factor: 12.701

3.  Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care--correlations with food intake, metabolism, exercise capacity, and hormones.

Authors:  Marita Fouladiun; Ulla Körner; Ingvar Bosaeus; Peter Daneryd; Anders Hyltander; Kent G Lundholm
Journal:  Cancer       Date:  2005-05-15       Impact factor: 6.860

Review 4.  Therapy insight: Cancer anorexia-cachexia syndrome--when all you can eat is yourself.

Authors:  Alessandro Laviano; Michael M Meguid; Akio Inui; Maurizio Muscaritoli; Filippo Rossi-Fanelli
Journal:  Nat Clin Pract Oncol       Date:  2005-03

5.  Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

Authors:  Paul Cohen; Julia D Levy; Yingying Zhang; Andrea Frontini; Dmitriy P Kolodin; Katrin J Svensson; James C Lo; Xing Zeng; Li Ye; Melin J Khandekar; Jun Wu; Subhadra C Gunawardana; Alexander S Banks; João Paulo G Camporez; Michael J Jurczak; Shingo Kajimura; David W Piston; Diane Mathis; Saverio Cinti; Gerald I Shulman; Patrick Seale; Bruce M Spiegelman
Journal:  Cell       Date:  2014-01-16       Impact factor: 41.582

6.  A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.

Authors:  Lawrence Kazak; Edward T Chouchani; Mark P Jedrychowski; Brian K Erickson; Kosaku Shinoda; Paul Cohen; Ramalingam Vetrivelan; Gina Z Lu; Dina Laznik-Bogoslavski; Sebastian C Hasenfuss; Shingo Kajimura; Steve P Gygi; Bruce M Spiegelman
Journal:  Cell       Date:  2015-10-22       Impact factor: 41.582

7.  Brown adipose tissue in cancer patients: possible cause of cancer-induced cachexia.

Authors:  F G Shellock; M S Riedinger; M C Fishbein
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

8.  PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.

Authors:  Serkan Kir; Hirotaka Komaba; Ana P Garcia; Konstantinos P Economopoulos; Wei Liu; Beate Lanske; Richard A Hodin; Bruce M Spiegelman
Journal:  Cell Metab       Date:  2015-12-06       Impact factor: 27.287

9.  Adipose triglyceride lipase contributes to cancer-associated cachexia.

Authors:  Suman K Das; Sandra Eder; Silvia Schauer; Clemens Diwoky; Hannes Temmel; Barbara Guertl; Gregor Gorkiewicz; Kuppusamy P Tamilarasan; Pooja Kumari; Michael Trauner; Robert Zimmermann; Paul Vesely; Guenter Haemmerle; Rudolf Zechner; Gerald Hoefler
Journal:  Science       Date:  2011-06-16       Impact factor: 47.728

10.  Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.

Authors:  Aaron M Cypess; Andrew P White; Cecile Vernochet; Tim J Schulz; Ruidan Xue; Christina A Sass; Tian Liang Huang; Carla Roberts-Toler; Lauren S Weiner; Cathy Sze; Aron T Chacko; Laura N Deschamps; Lindsay M Herder; Nathan Truchan; Allison L Glasgow; Ashley R Holman; Alina Gavrila; Per-Olof Hasselgren; Marcelo A Mori; Michael Molla; Yu-Hua Tseng
Journal:  Nat Med       Date:  2013-04-21       Impact factor: 53.440
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  34 in total

Review 1.  Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors.

Authors:  Ernst Lengyel; Liza Makowski; John DiGiovanni; Mikhail G Kolonin
Journal:  Trends Cancer       Date:  2018-04-05

2.  Preliminary investigation of brown adipose tissue assessed by PET/CT and cancer activity.

Authors:  Stijn A Bos; Corey M Gill; Edgar L Martinez-Salazar; Martin Torriani; Miriam A Bredella
Journal:  Skeletal Radiol       Date:  2018-09-13       Impact factor: 2.199

3.  Does the Poly (ADP-Ribose) Polymerase Inhibitor Veliparib Merit Further Study for Cancer-Associated Weight Loss? Observations and Conclusions from Sixty Prospectively Treated Patients.

Authors:  Jason D Doles; Kelly A Hogan; Jennifer O'Connor; Andrea E Wahner Hendrickson; Olivia Huston; Aminah Jatoi
Journal:  J Palliat Med       Date:  2018-05-24       Impact factor: 2.947

4.  The macroenviromental control of cancer metabolism by p62.

Authors:  Jianfeng Huang; Maria T Diaz-Meco; Jorge Moscat
Journal:  Cell Cycle       Date:  2018-09-20       Impact factor: 4.534

5.  Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor.

Authors:  Jianfeng Huang; Angeles Duran; Miguel Reina-Campos; Tania Valencia; Elias A Castilla; Timo D Müller; Matthias H Tschöp; Jorge Moscat; Maria T Diaz-Meco
Journal:  Cancer Cell       Date:  2018-04-09       Impact factor: 31.743

Review 6.  CircRNAs: Insights into Gastric Cancer.

Authors:  Sanjana Rajgopal; Sherine Joanna Fredrick; Venkatachalam Deepa Parvathi
Journal:  Gastrointest Tumors       Date:  2021-07-16

Review 7.  What Can 'Brown-ing' Do For You?

Authors:  Amar M Singh; Stephen Dalton
Journal:  Trends Endocrinol Metab       Date:  2018-03-29       Impact factor: 12.015

8.  Pheochromocytoma and Paraganglioma Patients With Poor Survival Often Show Brown Adipose Tissue Activation.

Authors:  Zahraa Abdul Sater; Abhishek Jha; Ahmed Hamimi; Adel Mandl; Iris R Hartley; Sriram Gubbi; Mayank Patel; Melissa Gonzales; David Taïeb; Ali Cahid Civelek; Ahmed M Gharib; Sungyoung Auh; Alana E O'Mara; Karel Pacak; Aaron M Cypess
Journal:  J Clin Endocrinol Metab       Date:  2020-04-01       Impact factor: 5.958

Review 9.  Altered glucose metabolism and insulin resistance in cancer-induced cachexia: a sweet poison.

Authors:  Tamhida Masi; Bhoomika M Patel
Journal:  Pharmacol Rep       Date:  2020-11-03       Impact factor: 3.024

10.  Brown adipose tissue and cancer progression.

Authors:  Katrina Chu; Stijn A Bos; Corey M Gill; Martin Torriani; Miriam A Bredella
Journal:  Skeletal Radiol       Date:  2019-10-24       Impact factor: 2.199
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