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Literature DB >> 29709261

Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors.

Ernst Lengyel¹, Liza Makowski², John DiGiovanni³, Mikhail G Kolonin⁴.

Abstract

Obesity has been linked to the increased risk and aggressiveness of many types of carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic stress, may contribute to carcinogenesis and cancer initiation. Evidence that AT plays a role in cancer aggressiveness is solid and mounting. During cancer progression, tumor cells engage in a metabolic symbiosis with adjacent AT. Mature adipocytes provide adipokines and lipids to cancer cells, while stromal and immune cells from AT infiltrate carcinomas and locally secrete paracrine factors within the tumor microenvironment. This review focuses on the crosstalk between AT and tumor cells that promotes tumor growth and increases cellular lipid metabolism, metastasis, and chemoresistance.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2018 PMID： 29709261 PMCID： PMC5932630 DOI： 10.1016/j.trecan.2018.03.004

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

105 in total

Review 1. Adipose tissue remodeling and obesity.

Authors: Kai Sun; Christine M Kusminski; Philipp E Scherer
Journal: J Clin Invest Date: 2011-06-01 Impact factor: 14.808

2. Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors.

Authors: Ann H Klopp; Yan Zhang; Travis Solley; Felipe Amaya-Manzanares; Frank Marini; Michael Andreeff; Bisrat Debeb; Wendy Woodward; Rosemarie Schmandt; Russell Broaddus; Karen Lu; Mikhail G Kolonin
Journal: Clin Cancer Res Date: 2011-12-13 Impact factor: 12.531

3. Circulation of progenitor cells in obese and lean colorectal cancer patients.

Authors: Charles F Bellows; Yan Zhang; Jinyun Chen; Marsha L Frazier; Mikhail G Kolonin
Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-09-19 Impact factor: 4.254

4. Proinflammatory CXCL12-CXCR4/CXCR7 Signaling Axis Drives Myc-Induced Prostate Cancer in Obese Mice.

Authors: Achinto Saha; Songyeon Ahn; Jorge Blando; Fei Su; Mikhail G Kolonin; John DiGiovanni
Journal: Cancer Res Date: 2017-07-07 Impact factor: 12.701

5. Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the gamma-H2AX focus assay and micronucleus test.

Authors: Roberto Scarpato; Carmela Verola; Barbara Fabiani; Vanessa Bianchi; Giuseppe Saggese; Giovanni Federico
Journal: FASEB J Date: 2010-11-10 Impact factor: 5.191

6. Proteolytic Isoforms of SPARC Induce Adipose Stromal Cell Mobilization in Obesity.

Authors: Chieh Tseng; Mikhail G Kolonin
Journal: Stem Cells Date: 2015-09-22 Impact factor: 6.277

7. PDGFRα/PDGFRβ signaling balance modulates progenitor cell differentiation into white and beige adipocytes.

Authors: Zhanguo Gao; Alexes C Daquinag; Fei Su; Brad Snyder; Mikhail G Kolonin
Journal: Development Date: 2018-01-04 Impact factor: 6.868

Review 8. Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.

Authors: Peter Arner; Dominique Langin
Journal: Trends Endocrinol Metab Date: 2014-04-11 Impact factor: 12.015

9. Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-β.

Authors: Valentina Mele; Manuele G Muraro; Diego Calabrese; Dennis Pfaff; Nunzia Amatruda; Francesca Amicarella; Brynn Kvinlaug; Chiara Bocelli-Tyndall; Ivan Martin; Therese J Resink; Michael Heberer; Daniel Oertli; Luigi Terracciano; Giulio C Spagnoli; Giandomenica Iezzi
Journal: Int J Cancer Date: 2014-01-30 Impact factor: 7.396

10. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.

Authors: Kari R Fischer; Anna Durrans; Sharrell Lee; Jianting Sheng; Fuhai Li; Stephen T C Wong; Hyejin Choi; Tina El Rayes; Seongho Ryu; Juliane Troeger; Robert F Schwabe; Linda T Vahdat; Nasser K Altorki; Vivek Mittal; Dingcheng Gao
Journal: Nature Date: 2015-11-11 Impact factor: 49.962

119 in total

Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors.

Review 1. Adipose tissue remodeling and obesity.

2. Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors.

3. Circulation of progenitor cells in obese and lean colorectal cancer patients.

4. Proinflammatory CXCL12-CXCR4/CXCR7 Signaling Axis Drives Myc-Induced Prostate Cancer in Obese Mice.

5. Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the gamma-H2AX focus assay and micronucleus test.

6. Proteolytic Isoforms of SPARC Induce Adipose Stromal Cell Mobilization in Obesity.

7. PDGFRα/PDGFRβ signaling balance modulates progenitor cell differentiation into white and beige adipocytes.

Review 8. Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.

9. Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-β.

10. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.

Review 1. Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti-tumor immunity.

Review 2. TGFβ biology in cancer progression and immunotherapy.

3. Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity.

4. Obesity, sleep apnea, and cancer.

Review 5. Obesity and cancer: A mechanistic overview of metabolic changes in obesity that impact genetic instability.

6. The role of adipose stroma in prostate cancer aggressiveness.

7. Coping with chemoresistance in prostate cancer-co-targeting of adipose stromal cells?

8. Perspective: Do Fasting, Caloric Restriction, and Diets Increase Sensitivity to Radiotherapy? A Literature Review.

Review 9. Environmental exposures, stem cells, and cancer.

Review 10. Studying Adipose Tissue in the Breast Tumor Microenvironment In Vitro: Progress and Opportunities.