Literature DB >> 2845667

Identification of HPV 16 early genes retained in cervical carcinomas.

S P Wilczynski1, L Pearlman, J Walker.   

Abstract

Fourteen cervical carcinomas containing HPV 16 DNA were analyzed by Southern blot hybridization with probes for HPV 16 E1, E2, E6, and E7 genes. All tumors hybridized with the E7 gene-specific probe while 2 tumors appear to be deleted in the E6 region. In 11 of the 14 tumors, deletions and/or rearrangements were detected in the E1 and E2 regions. Only one of the 14 tumors had a prototype HPV 16 restriction. Our findings that the E7 gene is the most conserved region of HPV 16 in cervical carcinomas suggest it may play a role in the maintenance of the malignant state.

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Year:  1988        PMID： 2845667     DOI： 10.1016/0042-6822(88)90539-9

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  9 in total

1.  The incidence of HPV in a Swedish series of invasive cervical carcinoma.

Authors:  B Hagmar; B Johansson; M Kalantari; Z Petersson; B Skyldberg; L Walaas
Journal:  Med Oncol Tumor Pharmacother       Date:  1992

2.  The integration of HPV-18 DNA in cervical carcinoma.

Authors:  S A Corden; L J Sant-Cassia; A J Easton; A G Morris
Journal:  Mol Pathol       Date:  1999-10

3.  The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties.

Authors:  J R Gage; C Meyers; F O Wettstein
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

4.  Analysis of integrated human papillomavirus type 16 DNA in cervical cancers: amplification of viral sequences together with cellular flanking sequences.

Authors:  M Wagatsuma; K Hashimoto; T Matsukura
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

5.  The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells.

Authors:  C L Halbert; G W Demers; D A Galloway
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

6.  Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma.

Authors:  Tomomi Yoshida; Takaaki Sano; Tetsunari Oyama; Tatsuya Kanuma; Toshio Fukuda
Journal:  Virchows Arch       Date:  2009-09       Impact factor: 4.064

Review 7.  Testing for human papillomavirus: basic pathobiology of infection, methodologies, and implications for clinical use.

Authors:  D C Wilbur; M H Stoler
Journal:  Yale J Biol Med       Date:  1991 Mar-Apr

8.  Transcriptional enhancer factor (TEF)-1 and its cell-specific co-activator activate human papillomavirus-16 E6 and E7 oncogene transcription in keratinocytes and cervical carcinoma cells.

Authors:  T Ishiji; M J Lace; S Parkkinen; R D Anderson; T H Haugen; T P Cripe; J H Xiao; I Davidson; P Chambon; L P Turek
Journal:  EMBO J       Date:  1992-06       Impact factor: 11.598

9.  Genomic organization of human papillomavirus type 18 in cervical cancer specimens.

Authors:  K Kitagawa; H Yoshikawa; T Onda; T Kawana; Y Taketani; H Yoshikura; A Iwamoto
Journal:  Jpn J Cancer Res       Date:  1996-03
  9 in total

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