Literature DB >> 28456387

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome.

Sarah B Mulkey1, Raghu H Ramakrishnaiah2, Robert C McKinstry3, Taeun Chang4, Amit M Mathur3, Dennis E Mayock5, Krisa P Van Meurs6, G Bradley Schaefer2, Chunqiao Luo2, Shasha Bai2, Sandra E Juul5, Yvonne W Wu7.   

Abstract

In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P = .004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01913340.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  brain volumetrics; diffusion weighted imaging; neuroprotection; newborn

Mesh：

Substances：

Year:  2017        PMID： 28456387     DOI： 10.1016/j.jpeds.2017.03.053

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  9 in total

1.  EPO improved neurologic outcome in rat pups late after traumatic brain injury.

Authors:  Michelle E Schober; Daniela F Requena; Christopher K Rodesch
Journal:  Brain Dev       Date:  2018-02-21       Impact factor: 1.961

Review 2.  Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells.

Authors:  Nienke Wagenaar; Caroline G M de Theije; Linda S de Vries; Floris Groenendaal; Manon J N L Benders; Cora H A Nijboer
Journal:  Pediatr Res       Date:  2017-11-01       Impact factor: 3.756

Review 3.  Erythropoietin as a Neuroprotective Drug for Newborn Infants: Ten Years after the First Use.

Authors:  Serafina Perrone; Chiara Lembo; Federica Gironi; Chiara Petrolini; Tiziana Catalucci; Giulia Corbo; Giuseppe Buonocore; Eloisa Gitto; Susanna Maria Roberta Esposito
Journal:  Antioxidants (Basel)       Date:  2022-03-28

Review 4.  Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy.

Authors:  Raymond C Koehler; Zeng-Jin Yang; Jennifer K Lee; Lee J Martin
Journal:  J Cereb Blood Flow Metab       Date:  2018-08-28       Impact factor: 6.200

Review 5.  Robust increases in erythropoietin production by the hypoxic fetus is a response to protect the brain and other vital organs.

Authors:  Kari A Teramo; Miira M Klemetti; John A Widness
Journal:  Pediatr Res       Date:  2018-06-12       Impact factor: 3.756

6.  Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy.

Authors:  Lauren L Jantzie; Akosua Y Oppong; Fatu S Conteh; Tracylyn R Yellowhair; Joshua Kim; Gabrielle Fink; Adam R Wolin; Frances J Northington; Shenandoah Robinson
Journal:  Front Neurol       Date:  2018-04-13       Impact factor: 4.003

Review 7.  New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy.

Authors:  Suresh Victor; Eridan Rocha-Ferreira; Ahad Rahim; Henrik Hagberg; David Edwards
Journal:  Eur J Pediatr       Date:  2021-11-24       Impact factor: 3.860

8.  Concurrent validity of the Warner Initial Developmental Evaluation of Adaptive and Functional Skills and the Bayley Scales of Infant and Toddler Development, Third Edition.

Authors:  Colleen Peyton; Michael E Msall; Kristen Wroblewski; Elizabeth E Rogers; Michael Kohn; Hannah C Glass
Journal:  Dev Med Child Neurol       Date:  2020-11-18       Impact factor: 5.449

Review 9.  Treatment of Neonatal Hypoxic-Ischemic Encephalopathy with Erythropoietin Alone, and Erythropoietin Combined with Hypothermia: History, Current Status, and Future Research.

Authors:  Dorothy E Oorschot; Rachel J Sizemore; Ashraf R Amer
Journal:  Int J Mol Sci       Date:  2020-02-21       Impact factor: 5.923
  9 in total

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