Literature DB >> 28455573

Filaggrin gene polymorphism associated with Epstein-Barr virus-associated tumors in China.

Yang Yang1, Wen Liu1, Zhenzhen Zhao1, Yan Zhang1,2, Hua Xiao1, Bing Luo3.   

Abstract

Mutations of filaggrin gene (FLG) have been identified as the cause of ichthyosis vulgaris, while recently FLG mutations were found to be associated with gastric cancer. This study aimed to investigate the association of filaggrin polymorphism with Epstein-Barr virus-associated tumors in China. A total of 200 patients with three types of tumors and 117 normal control samples were genotyped at three common FLG mutation loci (rs3126085, K4671X, R501X) by using Sequenom MassARRAY technique. The χ 2 test was used to evaluate the relationship between the mutation and the three kinds of tumors. A two-sided P value of <0.05 was considered statistically significant. The results showed that two single-nucleotide polymorphism (SNP) loci (rs3126085, K4671X) were significantly associated with nasopharyngeal carcinoma in genetic model. In addition, the two SNPs K4671X and rs3126085 were related to Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) and EBV-negative gastric carcinoma (EBVnGC), respectively. Furthermore, allele distributions in EBVaGC and EBVnGC were verified to be different in both SNP loci.

Entities:  

Keywords:  Epstein–Barr virus; Filaggrin; Gastric carcinoma; Nasopharyngeal carcinoma; SNP

Mesh：

Substances：

Year:  2017        PMID： 28455573     DOI： 10.1007/s11262-017-1463-x

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  26 in total

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Journal:  Nat Genet       Date:  2011-06-12       Impact factor: 38.330

4.  Four genetic variants interact to confer susceptibility to atopic dermatitis in Chinese Han population.

Authors:  Changbing Shen; Longdan Liu; Zengqiong Jiang; Xiaodong Zheng; Li Meng; Xianyong Yin; Jing Gao; Yujun Sheng; Jingping Gao; Yang Li; Fusheng Zhou; Fengli Xiao; Liangdan Sun; Yong Cui; Sen Yang; Xianbo Zuo; Xuejun Zhang
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Journal:  J Clin Pathol       Date:  1992-07       Impact factor: 3.411

6.  BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.

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7.  Undifferentiated, nonkeratinizing, and squamous cell carcinoma of the nasopharynx. Variants of Epstein-Barr virus-infected neoplasia.

Authors:  R Pathmanathan; U Prasad; G Chandrika; R Sadler; K Flynn; N Raab-Traub
Journal:  Am J Pathol       Date:  1995-06       Impact factor: 4.307

8.  Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect.

Authors:  Sara J Brown; Karin Kroboth; Aileen Sandilands; Linda E Campbell; Elizabeth Pohler; Sanja Kezic; Heather J Cordell; W H Irwin McLean; Alan D Irvine
Journal:  J Invest Dermatol       Date:  2011-11-10       Impact factor: 8.551

9.  Associations of filaggrin gene loss-of-function variants and human papillomavirus-related cancer and pre-cancer in Danish adults.

Authors:  Tea Skaaby; Lise Lotte N Husemoen; Torben Jørgensen; Jeanne D Johansen; Torkil Menné; Pal B Szecsi; Steen Stender; Peter Bager; Jacob P Thyssen; Allan Linneberg
Journal:  PLoS One       Date:  2014-06-06       Impact factor: 3.240

10.  Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.

Authors:  Frances J D Smith; Alan D Irvine; Ana Terron-Kwiatkowski; Aileen Sandilands; Linda E Campbell; Yiwei Zhao; Haihui Liao; Alan T Evans; David R Goudie; Sue Lewis-Jones; Gehan Arseculeratne; Colin S Munro; Ann Sergeant; Gráinne O'Regan; Sherri J Bale; John G Compton; John J DiGiovanna; Richard B Presland; Philip Fleckman; W H Irwin McLean
Journal:  Nat Genet       Date:  2006-01-29       Impact factor: 38.330
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  4 in total

1.  Filaggrin gene mutations with special reference to atopic dermatitis.

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2.  Bioinformatic Analyzes of the Association Between Upregulated Expression of JUN Gene via APOBEC-Induced FLG Gene Mutation and Prognosis of Cervical Cancer.

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3.  Association of FLG mutation with tumor mutation load and clinical outcomes in patients with gastric cancer.

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4.  Association of regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility in southern Chinese population.

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  4 in total

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