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Literature DB >> 28455552

Two new antimalarial quassinoid derivatives from the stems of Brucea javanica.

Parinuch Chumkaew¹, Jaraslak Pechwang², Theera Srisawat².

Abstract

Phytochemical investigation of the stems from Brucea javanica led to the isolation of two new quassinoids, brujavanol C (1) and brujavanol D (2), together with six known compounds (3-8). The chemical structures were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum and compounds 6 and 7 exhibited the most potent activity against the K1 strain, with IC50 values of 1.41 and 1.06 μM, respectively.

Entities: Chemical Species

Keywords: Antimalarial activity; Brucea javanica; Quassinoid; Simaroubaceae

Mesh：

Substances：

Year: 2017 PMID： 28455552 DOI： 10.1007/s11418-017-1089-2

Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343

15 in total

1. Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata.

Authors: Parinuch Chumkaew; Shigeru Kato; Kan Chantrapromma
Journal: Chem Pharm Bull (Tokyo) Date: 2006-09 Impact factor: 1.645

Review 2. Biologically active quassinoids and their chemistry: potential leads for drug design.

Authors: Z Guo; S Vangapandu; R W Sindelar; L A Walker; R D Sindelar
Journal: Curr Med Chem Date: 2005 Impact factor: 4.530

3. Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.

Authors: Phurpa Wangchuk; Paul A Keller; Stephen G Pyne; Malai Taweechotipatr; Aunchalee Tonsomboon; Roonglawan Rattanajak; Sumalee Kamchonwongpaisan
Journal: J Ethnopharmacol Date: 2011-06-28 Impact factor: 4.360

4. Antimalarial and cytotoxic quassinoids from the roots of Brucea javanica.

Authors: Parinuch Chumkaew; Theera Srisawat
Journal: J Asian Nat Prod Res Date: 2016-07-05 Impact factor: 1.569

5. Quassinoids from Eurycoma longifolia as plant growth inhibitors.

Authors: S Jiwajinda; V Santisopasri; A Murakami; N Hirai; H Ohigashi
Journal: Phytochemistry Date: 2001-11 Impact factor: 4.072

6. Cytotoxic quassinoids from Ailanthus altissima.

Authors: Yan Wang; Wen-Jing Wang; Chang Su; Dong-Mei Zhang; Li-Peng Xu; Rong-Rong He; Lei Wang; Jian Zhang; Xiao-Qi Zhang; Wen-Cai Ye
Journal: Bioorg Med Chem Lett Date: 2012-12-11 Impact factor: 2.823

7. In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.

Authors: Suratwadee Jiwajinda; Vilai Santisopasri; Akira Murakami; Hiromu Sugiyama; Monique Gasquet; Elias Riad; Guy Balansard; Hajime Ohigashi
Journal: J Ethnopharmacol Date: 2002-09 Impact factor: 4.360

8. Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids.

Authors: Chihiro Murakami; Narihiko Fukamiya; Sadaaki Tamura; Masayoshi Okano; Kenneth F Bastow; Harukuni Tokuda; Teruo Mukainaka; Hoyoky Nishino; Kuo-Hsiung Lee
Journal: Bioorg Med Chem Date: 2004-09-15 Impact factor: 3.641

Two new antimalarial quassinoid derivatives from the stems of Brucea javanica.

1. Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata.

Review 2. Biologically active quassinoids and their chemistry: potential leads for drug design.

3. Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.

4. Antimalarial and cytotoxic quassinoids from the roots of Brucea javanica.

5. Quassinoids from Eurycoma longifolia as plant growth inhibitors.

6. Cytotoxic quassinoids from Ailanthus altissima.

7. In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.

8. Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids.

9. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum.

10. Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.

Review 1. Antiplasmodial natural products: an update.

2. Two new quassinoids and other constituents from Picrasma javanica wood, and their biological activities.

3. New neolignans from the seeds of Myristica fragrans and their cytotoxic activities.

Review 4. Major Constituents From Brucea javanica and Their Pharmacological Actions.