Literature DB >> 2845379

Ectopic release of GHRH and ACTH from an adenoid cystic carcinoma resulting in acromegaly and complicated by pituitary infarction.

H J Southgate1, G P Archbold, M E el-Sayed, J Wright, V Marks.   

Abstract

A 23 year old man presented with a tumour mass in the lung. Subsequent investigation showed ectopic secretion of adrenocorticotrophic hormone (ACTH) and growth hormone releasing hormone (GHRH) from an adenoid cystic carcinoma. The patient progressed to show the clinical effects of long term exposure to high blood levels of both growth hormone and cortisol. The case was complicated by pituitary infarction. The very high blood levels of ACTH, growth hormone (GH) and GHRH proved resistant to treatment with the somatostatin analogue, SMS 201-995, and a possible side effect of the drug is reported. To our knowledge this is the first reported case of ectopic hormone secretion by an adenoid cystic carcinoma.

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Year:  1988        PMID： 2845379      PMCID： PMC2428788          DOI： 10.1136/pgmj.64.748.145

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  16 in total

1.  Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome.

Authors:  G W LIDDLE
Journal:  J Clin Endocrinol Metab       Date:  1960-12       Impact factor: 5.958

2.  Bronchial carcinoid tumour with acromegaly in two patients.

Authors:  F T Dabek
Journal:  J Clin Endocrinol Metab       Date:  1974-02       Impact factor: 5.958

3.  Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour.

Authors:  J Rivier; J Spiess; M Thorner; W Vale
Journal:  Nature       Date:  1982-11-18       Impact factor: 49.962

4.  Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor.

Authors:  M O Thorner; R L Perryman; M J Cronin; A D Rogol; M Draznin; A Johanson; W Vale; E Horvath; K Kovacs
Journal:  J Clin Invest       Date:  1982-11       Impact factor: 14.808

5.  Human pancreatic growth hormone-releasing factor-40 (hpGRF-40) allows stimulation of GH release by TRH.

Authors:  J L Borges; D R Uskavitch; D L Kaiser; M J Cronin; W S Evans; M O Thorner
Journal:  Endocrinology       Date:  1983-10       Impact factor: 4.736

6.  Partial purification and characterization of a peptide with growth hormone-releasing activity from extrapituitary tumors in patients with acromegaly.

Authors:  L A Frohman; M Szabo; M Berelowitz; M E Stachura
Journal:  J Clin Invest       Date:  1980-01       Impact factor: 14.808

7.  Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.

Authors:  R Guillemin; P Brazeau; P Böhlen; F Esch; N Ling; W B Wehrenberg
Journal:  Science       Date:  1982-11-05       Impact factor: 47.728

8.  Homogeneity in the growth hormone-lowering effect of dopamine and somatostatin in acromegaly.

Authors:  G Oppizzi; L Botalla; G Verde; R Cozzi; A Liuzzi; P G Chiodini
Journal:  J Clin Endocrinol Metab       Date:  1980-09       Impact factor: 5.958

9.  Nonspecific growth hormone responses to thyrotropin-releasing hormone in insulin-dependent diabetes: sex- and age-related pituitary responsiveness.

Authors:  G P Ceda; G Speroni; E Dall'Aglio; G Valenti; U Butturini
Journal:  J Clin Endocrinol Metab       Date:  1982-07       Impact factor: 5.958

10.  Growth hormone release inhibiting hormone in acromegaly.

Authors:  G M Besser; C H Mortimer; D Carr; A V Schally; D H Coy; D Evered; A J Kastin; W M Tunbridge; M O Thorner; R Hall
Journal:  Br Med J       Date:  1974-03-02
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  5 in total

1.  Ectopic ACTH Production and Cushing's Syndrome in a Patient with Parotid Acinic Cell Carcinoma with High-Grade Transformation: Tumor Context and Clinical Implications.

Authors:  Karan Saluja; Sanjita Ravishankar; Renata Ferrarotto; Hui Zhu; Kristen B Pytynia; Adel K El-Naggar
Journal:  Head Neck Pathol       Date:  2019-07-30

Review 2.  Ectopic secretion of growth hormone-releasing hormone in man.

Authors:  M Losa; J Schopohl; K von Werder
Journal:  J Endocrinol Invest       Date:  1993-01       Impact factor: 4.256

Review 3.  Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review.

Authors:  Iga Zendran; Gabriela Gut; Marcin Kałużny; Katarzyna Zawadzka; Marek Bolanowski
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-09       Impact factor: 6.055

Review 4.  Ectopic acromegaly due to growth hormone releasing hormone.

Authors:  Ali A Ghazi; Alireza Amirbaigloo; Azizollah Abbasi Dezfooli; Navid Saadat; Siavash Ghazi; Marina Pourafkari; Farrokh Tirgari; Dheepti Dhall; Serguei Bannykh; Shlomo Melmed; Odelia Cooper
Journal:  Endocrine       Date:  2012-09-15       Impact factor: 3.633

5.  Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production.

Authors:  Rie Tadokoro; Shotaro Sato; Fumiko Otsuka; Makoto Ueno; Shinichi Ohkawa; Hideki Katakami; Matsuo Taniyama; Shoichiro Nagasaka
Journal:  Intern Med       Date:  2016-10-15       Impact factor: 1.271
  5 in total

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