Ferdinand Roelfsema1, Rebecca J Yang2, Thomas P Olson3, Michael J Joyner4, Paul Y Takahashi5, Johannes D Veldhuis2. 1. Department of Endocrinology and Metabolism, Leiden University Medical Center, 2333ZA Leiden, The Netherlands. 2. Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota 55905. 3. Department of Cardiovascular Research, Mayo Clinic, Rochester, Minnesota 55905. 4. Department of Anesthesia Research, Department of Physiology and Biomedical Engineering, and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905. 5. Department of Primary Care Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Abstract
Context: Exercise elicits incompletely defined adaptations of metabolic and endocrine milieu, including the gonadotropic and corticotropic axes. Objective: To quantify the impact of acute exercise on coordinate luteinizing hormone (LH) and testosterone (T) and adrenocorticotropic hormone (ACTH) and cortisol secretion in healthy men in relation to age. Participants and Design: Prospectively randomized, within-subject crossover study in 23 men aged 19 to 77 years old. Subjects underwent rest and 30 minutes of mixed exercise at 65% of maximal aerobic capacity with 10-minute blood sampling between 7:00 am and 1:00 pm, 2 weeks apart. Main Outcome Measures: Incremental changes in LH, T, ACTH, and cortisol concentrations, the feedforward and feedback strength between exercise and rest, quantified by approximate entropy (ApEn), and bihormonal synchrony, quantitated by cross-ApEn. Results:Mean hourly exercise-minus-rest LH and ACTH increments increased from -0.055 ± 0.187 to 0.755 ± 0.245 IU/L (P = 0.003) and from 2.9 ± 2.2 to 71.2 ± 16.1 ng/L (P < 0.0001), respectively, during exercise. T and cortisol increments increased concurrently from -9.6 ± 16.7 to 47.6 ± 17.1 ng/dL (P < 0.0001) and 0.45 ± 0.76 to 7.27 ± 0.64 µg/dL (P < 0.0001), respectively. During exercise, feedforward and feedback LH-T and ACTH-cortisol cross-ApEn decreased markedly quantifying enhanced hormonal coupling. Conclusions: Acute moderate mixed exercise in healthy men rapidly enhances feedforward LH-T and ACTH-cortisol coordination and reciprocal feedback within the gonadotropic and corticotropic axes. In principle, enhancement of both LH-T and ACTH-cortisol secretory synchrony by exercise could reflect augmented coupling between brain-testicular and brain-adrenal neural outflow.
RCT Entities:
Context: Exercise elicits incompletely defined adaptations of metabolic and endocrine milieu, including the gonadotropic and corticotropic axes. Objective: To quantify the impact of acute exercise on coordinate luteinizing hormone (LH) and testosterone (T) and adrenocorticotropic hormone (ACTH) and cortisol secretion in healthy men in relation to age. Participants and Design: Prospectively randomized, within-subject crossover study in 23 men aged 19 to 77 years old. Subjects underwent rest and 30 minutes of mixed exercise at 65% of maximal aerobic capacity with 10-minute blood sampling between 7:00 am and 1:00 pm, 2 weeks apart. Main Outcome Measures: Incremental changes in LH, T, ACTH, and cortisol concentrations, the feedforward and feedback strength between exercise and rest, quantified by approximate entropy (ApEn), and bihormonal synchrony, quantitated by cross-ApEn. Results: Mean hourly exercise-minus-rest LH and ACTH increments increased from -0.055 ± 0.187 to 0.755 ± 0.245 IU/L (P = 0.003) and from 2.9 ± 2.2 to 71.2 ± 16.1 ng/L (P < 0.0001), respectively, during exercise. T and cortisol increments increased concurrently from -9.6 ± 16.7 to 47.6 ± 17.1 ng/dL (P < 0.0001) and 0.45 ± 0.76 to 7.27 ± 0.64 µg/dL (P < 0.0001), respectively. During exercise, feedforward and feedback LH-T and ACTH-cortisol cross-ApEn decreased markedly quantifying enhanced hormonal coupling. Conclusions: Acute moderate mixed exercise in healthy men rapidly enhances feedforward LH-T and ACTH-cortisol coordination and reciprocal feedback within the gonadotropic and corticotropic axes. In principle, enhancement of both LH-T and ACTH-cortisol secretory synchrony by exercise could reflect augmented coupling between brain-testicular and brain-adrenal neural outflow.
Authors: R M Buijs; J Wortel; J J Van Heerikhuize; M G Feenstra; G J Ter Horst; H J Romijn; A Kalsbeek Journal: Eur J Neurosci Date: 1999-05 Impact factor: 3.386
Authors: Johannes D Veldhuis; Thomas P Olson; Paul Y Takahashi; John M Miles; Michael J Joyner; Rebecca J Yang; Jean Wigham Journal: Metabolism Date: 2015-05-15 Impact factor: 8.694
Authors: Mikel Izquierdo; Javier Ibañez; Jose A L Calbet; Ion Navarro-Amezqueta; Miriam González-Izal; Fernando Idoate; Keijo Häkkinen; William J Kraemer; Mercedes Palacios-Sarrasqueta; Mar Almar; Esteban M Gorostiaga Journal: Eur J Appl Physiol Date: 2009-08-01 Impact factor: 3.078
Authors: Ferdinand Roelfsema; Peter Y Liu; Rebecca Yang; Paul Takahashi; Johannes D Veldhuis Journal: Endocr Connect Date: 2020-07 Impact factor: 3.335