Johannes D Veldhuis1, Thomas P Olson2, Paul Y Takahashi3, John M Miles4, Michael J Joyner5, Rebecca J Yang4, Jean Wigham4. 1. Endocrine Research Unit, Mayo Clinic College of Medicine, Center for Translational Science Activities. Electronic address: veldhuis.johannes@mayo.edu. 2. Cardiovascular Research, Mayo Clinic, Rochester, MN 55905. 3. Primary Care Internal Medicine, Mayo Clinic, Rochester, MN 55905. 4. Endocrine Research Unit, Mayo Clinic College of Medicine, Center for Translational Science Activities. 5. Anesthesia Research, Mayo Clinic, Rochester, MN 55905.
Abstract
OBJECTIVE: Exercise evokes pulsatile GH release followed by autonegative feedback, whereas glucose suppresses GH release followed by rebound-like GH release (feedforward escape). Here we test the hypothesis that age, sex steroids, insulin, body composition and physical power jointly determine these dynamic GH responses. METHODS: This was a prospectively randomized glucose-blinded study conducted in the Mayo Center for Advancing Translational Sciences in healthy men ages 19-77 years (N=23). Three conditions, fasting/rest/saline, fasting/exercise/saline and fasting/rest/iv glucose infusions, were used to drive GH dynamics during 10-min blood sampling for 6h. Linear correlation analysis was applied to relate peak/nadir GH dynamics to age, sex steroids, insulin, CT-estimated abdominal fat and physical power (work per unit time). RESULTS: Compared with the fasting/rest/saline (control) day, fasting/exercise/saline infusion evoked peak GH within 1h, followed by negative feedback 3-5h later. The dynamic GH excursion was strongly (R(2)=0.634) influenced by (i) insulin negatively (P=0.011), (ii) power positively (P=0.0008), and (iii) E2 positively (P=0.001). Dynamic glucose-modulated GH release was determined by insulin negatively (P=0.0039) and power positively (P=0.0034) (R(2)=0.454). Under rest/saline, power (P=0.031) and total abdominal fat (P=0.012) (R(2)=0.267) were the dominant correlates of GH excursions. CONCLUSION: In healthy men, dynamic GH perturbations induced by exercise and glucose are strongly related to physical power, insulin, estradiol, and body composition, thus suggesting a network of regulatory pathways.
RCT Entities:
OBJECTIVE: Exercise evokes pulsatile GH release followed by autonegative feedback, whereas glucose suppresses GH release followed by rebound-like GH release (feedforward escape). Here we test the hypothesis that age, sex steroids, insulin, body composition and physical power jointly determine these dynamic GH responses. METHODS: This was a prospectively randomized glucose-blinded study conducted in the Mayo Center for Advancing Translational Sciences in healthy men ages 19-77 years (N=23). Three conditions, fasting/rest/saline, fasting/exercise/saline and fasting/rest/iv glucose infusions, were used to drive GH dynamics during 10-min blood sampling for 6h. Linear correlation analysis was applied to relate peak/nadirGH dynamics to age, sex steroids, insulin, CT-estimated abdominal fat and physical power (work per unit time). RESULTS: Compared with the fasting/rest/saline (control) day, fasting/exercise/saline infusion evoked peak GH within 1h, followed by negative feedback 3-5h later. The dynamic GH excursion was strongly (R(2)=0.634) influenced by (i) insulin negatively (P=0.011), (ii) power positively (P=0.0008), and (iii) E2 positively (P=0.001). Dynamic glucose-modulated GH release was determined by insulin negatively (P=0.0039) and power positively (P=0.0034) (R(2)=0.454). Under rest/saline, power (P=0.031) and total abdominal fat (P=0.012) (R(2)=0.267) were the dominant correlates of GH excursions. CONCLUSION: In healthy men, dynamic GH perturbations induced by exercise and glucose are strongly related to physical power, insulin, estradiol, and body composition, thus suggesting a network of regulatory pathways.
Authors: P Rietschel; C Hadigan; C Corcoran; T Stanley; G Neubauer; J Gertner; S Grinspoon Journal: J Clin Endocrinol Metab Date: 2001-02 Impact factor: 5.958
Authors: L S Farhy; M Straume; M L Johnson; B Kovatchev; J D Veldhuis Journal: Am J Physiol Regul Integr Comp Physiol Date: 2001-07 Impact factor: 3.619
Authors: J L Clasey; A Weltman; J Patrie; J Y Weltman; S Pezzoli; C Bouchard; M O Thorner; M L Hartman Journal: J Clin Endocrinol Metab Date: 2001-08 Impact factor: 5.958
Authors: L Wideman; J Y Weltman; J T Patrie; C Y Bowers; N Shah; S Story; A Weltman; J D Veldhuis Journal: Am J Physiol Regul Integr Comp Physiol Date: 2000-10 Impact factor: 3.619
Authors: M H Rasmussen; A Hvidberg; A Juul; K M Main; A Gotfredsen; N E Skakkebaek; J Hilsted; N E Skakkebae Journal: J Clin Endocrinol Metab Date: 1995-04 Impact factor: 5.958
Authors: Ferdinand Roelfsema; Rebecca J Yang; Thomas P Olson; Michael J Joyner; Paul Y Takahashi; Johannes D Veldhuis Journal: J Clin Endocrinol Metab Date: 2017-07-01 Impact factor: 5.958