Literature DB >> 28453487

Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report.

Ganesh M Babulal1,2, Sarah H Stout1,2, Denise Head1,3,4, David M Holtzman1,2,5, Anne M Fagan1,2,5, John C Morris1,2,5,6,7,8, Catherine M Roe1,2.   

Abstract

We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-β42 [Aβ42], tau, phosphorylated tau181 [ptau181], tau/Aβ42, and ptau181/Aβ42) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N = 116) aged ≥65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (Aβ42, tau/Aβ42, ptau181/Aβ42) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.

Entities:  

Keywords:  Alzheimer’s disease; cerebrospinal fluid; depression; neuropsychology; noncognitive outcomes; preclinical

Mesh：

Substances：

Year:  2017        PMID： 28453487      PMCID： PMC5555740          DOI： 10.3233/JAD-170067

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  14 in total

1.  Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment.

Authors:  Zahinoor Ismail; Eric E Smith; Yonas Geda; David Sultzer; Henry Brodaty; Gwenn Smith; Luis Agüera-Ortiz; Rob Sweet; David Miller; Constantine G Lyketsos
Journal:  Alzheimers Dement       Date:  2015-06-18       Impact factor: 21.566

2.  "Noncognitive" symptoms of early Alzheimer disease: a longitudinal analysis.

Authors:  Mary Clare Masters; John C Morris; Catherine M Roe
Journal:  Neurology       Date:  2015-02-10       Impact factor: 9.910

3.  Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults.

Authors:  Anne M Fagan; Catherine M Roe; Chengjie Xiong; Mark A Mintun; John C Morris; David M Holtzman
Journal:  Arch Neurol       Date:  2007-01-08

4.  The Clinical Dementia Rating (CDR): current version and scoring rules.

Authors:  J C Morris
Journal:  Neurology       Date:  1993-11       Impact factor: 9.910

5.  Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory.

Authors:  D I Kaufer; J L Cummings; P Ketchel; V Smith; A MacMillan; T Shelley; O L Lopez; S T DeKosky
Journal:  J Neuropsychiatry Clin Neurosci       Date:  2000       Impact factor: 2.198

6.  Longitudinal driving performance in early-stage dementia of the Alzheimer type.

Authors:  Janet M Duchek; David B Carr; Linda Hunt; Catherine M Roe; Chengjie Xiong; Kamini Shah; John C Morris
Journal:  J Am Geriatr Soc       Date:  2003-10       Impact factor: 5.562

7.  Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals.

Authors:  Catherine M Roe; Peggy P Barco; Denise M Head; Nupur Ghoshal; Natalie Selsor; Ganesh M Babulal; Rebecca Fierberg; Elizabeth K Vernon; Neal Shulman; Ann Johnson; Scot Fague; Chengjie Xiong; Elizabeth A Grant; Angela Campbell; Brian R Ott; David M Holtzman; Tammie L S Benzinger; Anne M Fagan; David B Carr; John C Morris
Journal:  Alzheimer Dis Assoc Disord       Date:  2017 Jan-Mar       Impact factor: 2.703

8.  Accuracy of collateral source reports in very mild to mild dementia of the Alzheimer type.

Authors:  Pamela Z Cacchione; Kimberly K Powlishta; Elizabeth A Grant; Virginia D Buckles; John C Morris
Journal:  J Am Geriatr Soc       Date:  2003-06       Impact factor: 5.562

9.  Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels.

Authors:  Ganesh M Babulal; Nupur Ghoshal; Denise Head; Elizabeth K Vernon; David M Holtzman; Tammie L S Benzinger; Anne M Fagan; John C Morris; Catherine M Roe
Journal:  Am J Geriatr Psychiatry       Date:  2016-04-19       Impact factor: 4.105

Review 10.  Preclinical Alzheimer disease-the challenges ahead.

Authors:  Reisa A Sperling; Jason Karlawish; Keith A Johnson
Journal:  Nat Rev Neurol       Date:  2012-11-27       Impact factor: 42.937
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  6 in total

1.  Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.

Authors:  Ganesh M Babulal; Suzie Chen; Monique M Williams; Jean-Francois Trani; Parul Bakhshi; Grace L Chao; Sarah H Stout; Anne M Fagan; Tammie L S Benzinger; David M Holtzman; John C Morris; Catherine M Roe
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

2.  Using Naturalistic Driving Data to Predict Mild Cognitive Impairment and Dementia: Preliminary Findings from the Longitudinal Research on Aging Drivers (LongROAD) Study.

Authors:  Xuan Di; Rongye Shi; Carolyn DiGuiseppi; David W Eby; Linda L Hill; Thelma J Mielenz; Lisa J Molnar; David Strogatz; Howard F Andrews; Terry E Goldberg; Barbara H Lang; Minjae Kim; Guohua Li
Journal:  Geriatrics (Basel)       Date:  2021-04-23

Review 3.  Driving and Alzheimer's dementia or mild cognitive impairment: a systematic review of the existing guidelines emphasizing on the neurologist's role.

Authors:  Petros Stamatelos; Alexandra Economou; Leonidas Stefanis; George Yannis; Sokratis G Papageorgiou
Journal:  Neurol Sci       Date:  2021-09-28       Impact factor: 3.307

4.  The Effect of Type 2 Diabetes Mellitus on Neuropsychological Symptoms in Chinese Early Alzheimer's Disease Population.

Authors:  Qianqian Shi; Faying Zhou; Jing Mei; Haimei Yang; Huiyun Li
Journal:  Neuropsychiatr Dis Treat       Date:  2020-03-26       Impact factor: 2.570

5.  Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals.

Authors:  Firoza Z Lussier; Tharick A Pascoal; Mira Chamoun; Joseph Therriault; Cécile Tissot; Mélissa Savard; Min Su Kang; Sulantha Mathotaarachchi; Andrea L Benedet; Marlee Parsons; Muhammad Naveed Iqbal Qureshi; Émilie M Thomas; Monica Shin; Laurie-Anne Dion; Gassan Massarweh; Jean-Paul Soucy; I-Huang Tsai; Paolo Vitali; Zahinoor Ismail; Pedro Rosa-Neto; Serge Gauthier
Journal:  Alzheimers Dement       Date:  2020-01       Impact factor: 21.566

6.  GPS driving: a digital biomarker for preclinical Alzheimer disease.

Authors:  Sayeh Bayat; Ganesh M Babulal; Suzanne E Schindler; Anne M Fagan; John C Morris; Alex Mihailidis; Catherine M Roe
Journal:  Alzheimers Res Ther       Date:  2021-06-14       Impact factor: 6.982
  6 in total

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