| Literature DB >> 28450583 |
Xin'Ai Zhao1, Jonathan Bramsiepe2, Matthias Van Durme3,4, Shinichiro Komaki1, Maria Ada Prusicki1, Daisuke Maruyama5,6, Joachim Forner7, Anna Medzihradszky7, Erik Wijnker1, Hirofumi Harashima8, You Lu9, Anja Schmidt10, Daniela Guthörl10, Rosa Sahún Logroño10, Yonsheng Guan2, Gaetan Pochon1, Ueli Grossniklaus10, Thomas Laux9, Tetsuya Higashiyama5,11, Jan U Lohmann7, Moritz K Nowack3,4, Arp Schnittger12,2.
Abstract
To produce seeds, flowering plants need to specify somatic cells to undergo meiosis. Here, we reveal a regulatory cascade that controls the entry into meiosis starting with a group of redundantly acting cyclin-dependent kinase (CDK) inhibitors of the KIP-RELATED PROTEIN (KRP) class. KRPs function by restricting CDKA;1-dependent inactivation of the Arabidopsis Retinoblastoma homolog RBR1. In rbr1 and krp triple mutants, designated meiocytes undergo several mitotic divisions, resulting in the formation of supernumerary meiocytes that give rise to multiple reproductive units per future seed. One function of RBR1 is the direct repression of the stem cell factor WUSCHEL (WUS), which ectopically accumulates in meiocytes of triple krp and rbr1 mutants. Depleting WUS in rbr1 mutants restored the formation of only a single meiocyte.Entities:
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Year: 2017 PMID： 28450583 DOI： 10.1126/science.aaf6532
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728