| Literature DB >> 28449872 |
Tim D Smith1, Raji R Nagalla1, Esther Y Chen2, Wendy F Liu3.
Abstract
Macrophages are versatile and plastic effector cells of the immune system, and contribute to diverse immune functions including pathogen or apoptotic cell removal, inflammatory activation and resolution, and tissue healing. Macrophages function as signaling regulators and amplifiers, and influencing their activity is a powerful approach for controlling inflammation or inducing a wound-healing response in regenerative medicine. This review discusses biomaterials-based approaches for altering macrophage activity, approaches for targeting drugs to macrophages, and approaches for delivering macrophages themselves as a therapeutic intervention.Entities:
Keywords: Biomaterials; Immunomodulation; Macrophage polarization; Nanoparticles; Wound healing
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Year: 2017 PMID： 28449872 DOI： 10.1016/j.addr.2017.04.012
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470