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Literature DB >> 28446786

How and why do T cells and their derived cytokines affect the injured and healthy brain?

Anthony J Filiano¹, Sachin P Gadani¹, Jonathan Kipnis¹.

Abstract

The evolution of adaptive immunity provides enhanced defence against specific pathogens, as well as homeostatic immune surveillance of all tissues. Despite being 'immune privileged', the CNS uses the assistance of the immune system in physiological and pathological states. In this Opinion article, we discuss the influence of adaptive immunity on recovery after CNS injury and on cognitive and social brain function. We further extend a hypothesis that the pro-social effects of interferon-regulated genes were initially exploited by pathogens to increase host-host transmission, and that these genes were later recycled by the host to form part of an immune defence programme. In this way, the evolution of adaptive immunity may reflect a host-pathogen 'arms race'.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Cytokines

Year: 2017 PMID： 28446786 PMCID： PMC5823005 DOI： 10.1038/nrn.2017.39

Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870

125 in total

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Review 3. The impact of gut microbiota on brain and behaviour: implications for psychiatry.

Authors: Timothy G Dinan; John F Cryan
Journal: Curr Opin Clin Nutr Metab Care Date: 2015-11 Impact factor: 4.294

4. Regulatory T cells in CNS injury: the simple, the complex and the confused.

Authors: James T Walsh; Jonathan Kipnis
Journal: Trends Mol Med Date: 2011-07-07 Impact factor: 11.951

5. In the company of cowbirds, Molothrus ater ater: robust patterns of sociability predict reproductive performance.

Authors: Gregory M Kohn; Andrew P King; Rebekka Dohme; Gwendŵr R Meredith; Meredith J West
Journal: J Comp Psychol Date: 2012-10-01 Impact factor: 2.231

6. Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system.

Authors: Jonathan Kipnis; Tal Mizrahi; Ehud Hauben; Iftach Shaked; Ethan Shevach; Michal Schwartz
Journal: Proc Natl Acad Sci U S A Date: 2002-11-12 Impact factor: 11.205

Review 7. Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge.

Authors: Leonardo H Tonelli; Teodor T Postolache
Journal: Neurol Res Date: 2005-10 Impact factor: 2.448

8. Regulatory T cells in central nervous system injury: a double-edged sword.

Authors: James T Walsh; Jingjing Zheng; Igor Smirnov; Ulrike Lorenz; Kenneth Tung; Jonathan Kipnis
Journal: J Immunol Date: 2014-10-15 Impact factor: 5.422

Review 9. Transgenic models for cytokine-induced neurological disease.

Authors: Iain L Campbell; Markus J Hofer; Axel Pagenstecher
Journal: Biochim Biophys Acta Date: 2009-10-14

10. Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: implications for protective autoimmunity.

Authors: Rina Barouch; Michal Schwartz
Journal: FASEB J Date: 2002-06-21 Impact factor: 5.191

64 in total

Review 1. Neuromodulation by the immune system: a focus on cytokines.

Authors: Andrea Francesca Salvador; Kalil Alves de Lima; Jonathan Kipnis
Journal: Nat Rev Immunol Date: 2021-03-01 Impact factor: 53.106

2. An in vivo brain-bacteria interface: the developing brain as a key regulator of innate immunity.

Authors: Celia Herrera-Rincon; Jean-Francois Paré; Christopher J Martyniuk; Sophia K Jannetty; Christina Harrison; Alina Fischer; Alexandre Dinis; Vishal Keshari; Richard Novak; Michael Levin
Journal: NPJ Regen Med Date: 2020-02-04

3. High-dimensional, single-cell characterization of the brain's immune compartment.

Authors: Ben Korin; Tamar L Ben-Shaanan; Maya Schiller; Tania Dubovik; Hilla Azulay-Debby; Nadia T Boshnak; Tamar Koren; Asya Rolls
Journal: Nat Neurosci Date: 2017-07-24 Impact factor: 24.884

Review 4. Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity.

Authors: Ari Waisman; Lisa Johann
Journal: J Mol Med (Berl) Date: 2018-11-01 Impact factor: 4.599

5. Increased circulating regulatory T cells in medicated people with schizophrenia.

Authors: Deanna L Kelly; Xin Li; Catherine Kilday; Stephanie Feldman; Sarah Clark; Fang Liu; Robert W Buchanan; Leonardo H Tonelli
Journal: Psychiatry Res Date: 2018-09-05 Impact factor: 3.222

Review 6. Emerging mechanistic underpinnings and therapeutic targets for chemotherapy-related cognitive impairment.

Authors: Erin M Gibson; Michelle Monje
Journal: Curr Opin Oncol Date: 2019-11 Impact factor: 3.645

7. Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood.

Authors: Sarah M Clark; Francesca M Notarangelo; Xin Li; Shuo Chen; Robert Schwarcz; Leonardo H Tonelli
Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2018-09-27 Impact factor: 5.067