Literature DB >> 28444741

Haem augments and iron chelation decreases toll-like receptor 4 mediated inflammation in monocytes from sickle cell patients.

Pradeep K Dagur1, J Philip McCoy1, James Nichols1, Laura Mendelsohn1, Catherine Seamon1, Gregory J Kato2, Eduard J van Beers3.   

Abstract

Entities:  

Keywords:  inflammation; iron metabolism; monocytes; sickle cell disease; toll-like receptor 4

Mesh：

Substances：

Year:  2017        PMID： 28444741      PMCID： PMC5869174          DOI： 10.1111/bjh.14663

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


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  10 in total

1.  Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation.

Authors:  Patricia L Fernandez; Fabianno F Dutra; Letícia Alves; Rodrigo T Figueiredo; Diego Mourão-Sa; Guilherme B Fortes; Sophie Bergstrand; David Lönn; Ricardo R Cevallos; Renata M S Pereira; Ulisses G Lopes; Leonardo H Travassos; Claudia N Paiva; Marcelo T Bozza
Journal:  J Biol Chem       Date:  2010-08-20       Impact factor: 5.157

2.  Fluorescence analysis of the labile iron pool of mammalian cells.

Authors:  S Epsztejn; O Kakhlon; H Glickstein; W Breuer; I Cabantchik
Journal:  Anal Biochem       Date:  1997-05-15       Impact factor: 3.365

3.  Iron, inflammation, and early death in adults with sickle cell disease.

Authors:  Eduard J van Beers; Yanqin Yang; Nalini Raghavachari; Xin Tian; Darlene T Allen; James S Nichols; Laurel Mendelsohn; Sergei Nekhai; Victor R Gordeuk; James G Taylor; Gregory J Kato
Journal:  Circ Res       Date:  2014-11-06       Impact factor: 17.367

4.  Mortality in sickle cell disease. Life expectancy and risk factors for early death.

Authors:  O S Platt; D J Brambilla; W F Rosse; P F Milner; O Castro; M H Steinberg; P P Klug
Journal:  N Engl J Med       Date:  1994-06-09       Impact factor: 91.245

5.  Extracellular hemin crisis triggers acute chest syndrome in sickle mice.

Authors:  Samit Ghosh; Olufolake Adetoro Adisa; Prasanthi Chappa; Fang Tan; Kesmic Ann Jackson; David Robert Archer; Solomon Fiifi Ofori-Acquah
Journal:  J Clin Invest       Date:  2013-11       Impact factor: 14.808

6.  Characterization of heme as activator of Toll-like receptor 4.

Authors:  Rodrigo T Figueiredo; Patricia L Fernandez; Diego S Mourao-Sa; Bárbara N Porto; Fabianno F Dutra; Letícia S Alves; Marcus F Oliveira; Pedro L Oliveira; Aurélio V Graça-Souza; Marcelo T Bozza
Journal:  J Biol Chem       Date:  2007-05-14       Impact factor: 5.157

7.  Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

Authors:  John D Belcher; Chunsheng Chen; Julia Nguyen; Liming Milbauer; Fuad Abdulla; Abdu I Alayash; Ann Smith; Karl A Nath; Robert P Hebbel; Gregory M Vercellotti
Journal:  Blood       Date:  2013-11-25       Impact factor: 22.113

8.  H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice.

Authors:  Gregory M Vercellotti; Fatima B Khan; Julia Nguyen; Chunsheng Chen; Carol M Bruzzone; Heather Bechtel; Graham Brown; Karl A Nath; Clifford J Steer; Robert P Hebbel; John D Belcher
Journal:  Front Pharmacol       Date:  2014-04-17       Impact factor: 5.810

9.  Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.

Authors:  Francesca Vinchi; Milene Costa da Silva; Giada Ingoglia; Sara Petrillo; Nathan Brinkman; Adrian Zuercher; Adelheid Cerwenka; Emanuela Tolosano; Martina U Muckenthaler
Journal:  Blood       Date:  2015-12-16       Impact factor: 22.113

10.  On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.

Authors:  Igor Theurl; Ingo Hilgendorf; Manfred Nairz; Piotr Tymoszuk; David Haschka; Malte Asshoff; Shun He; Louisa M S Gerhardt; Tobias A W Holderried; Markus Seifert; Sieghart Sopper; Ashley M Fenn; Atsushi Anzai; Sara Rattik; Cameron McAlpine; Milan Theurl; Peter Wieghofer; Yoshiko Iwamoto; Georg F Weber; Nina K Harder; Benjamin G Chousterman; Tara L Arvedson; Mary McKee; Fudi Wang; Oliver M D Lutz; Emanuele Rezoagli; Jodie L Babitt; Lorenzo Berra; Marco Prinz; Matthias Nahrendorf; Guenter Weiss; Ralph Weissleder; Herbert Y Lin; Filip K Swirski
Journal:  Nat Med       Date:  2016-07-18       Impact factor: 53.440
  10 in total
  4 in total

1.  Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease.

Authors:  Raisa Balbuena-Merle; Susanna A Curtis; Lesley Devine; David R Gibb; Matthew S Karafin; Chance John Luckey; Christopher A Tormey; Alexa J Siddon; John D Roberts; Jeanne E Hendrickson
Journal:  Transfusion       Date:  2019-07-29       Impact factor: 3.157

2.  Hydroxyurea alters circulating monocyte subsets and dampens its inflammatory potential in sickle cell anemia patients.

Authors:  Caroline C Guarda; Paulo S M Silveira-Mattos; Sètondji C M A Yahouédéhou; Rayra P Santiago; Milena M Aleluia; Camylla V B Figueiredo; Luciana M Fiuza; Suellen P Carvalho; Rodrigo M Oliveira; Valma M L Nascimento; Nívea F Luz; Valéria M Borges; Bruno B Andrade; Marilda S Gonçalves
Journal:  Sci Rep       Date:  2019-10-15       Impact factor: 4.379

Review 3.  Innate immune cells, major protagonists of sickle cell disease pathophysiology.

Authors:  Slimane Allali; Thiago Trovati Maciel; Olivier Hermine; Mariane de Montalembert
Journal:  Haematologica       Date:  2020-01-31       Impact factor: 9.941

4.  A Unique Monocyte Transcriptome Discriminates Sickle Cell Disease From Other Hereditary Hemolytic Anemias and Shows the Particular Importance of Lipid and Interferon Signaling.

Authors:  Annelies J van Vuren; Stephanie van Straaten; Michal Mokry; Richard van Wijk; Eduard J van Beers
Journal:  Hemasphere       Date:  2021-02-10
  4 in total

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