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Literature DB >> 284360

Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.

W M Generoso, K T Cain, M Krishna, S W Huff.

Abstract

Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of first-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine, and benzo[a]pyrene treatments; and no difference was found for x-ray treatment.

Entities: Chemical Disease Species

Mesh：

Substances：
Mutagens

Year: 1979 PMID： 284360 PMCID： PMC382954 DOI： 10.1073/pnas.76.1.435

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

8 in total

1. EMBRYONIC LETHALITY OF VARIOUS MOUSE STRAINS AS A CONSEQUENCE OF X-IRRADIATION-INDUCED INJURIES OF THE FATHER'S SPERMATOZOA.

Authors: H FROELEN
Journal: Radiat Res Date: 1965-08 Impact factor: 2.841

2. Radiation dose rate and mutation frequency.

Authors: W L RUSSELL; L B RUSSELL; E M KELLY
Journal: Science Date: 1958-12-19 Impact factor: 47.728

3. Ultraviolet light-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation.

Authors: Y Masui; R A Pedersen
Journal: Nature Date: 1975-10-23 Impact factor: 49.962

4. Changing levels of uv light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation.

Authors: J L Brazill; Y Masui
Journal: Exp Cell Res Date: 1978-03-01 Impact factor: 3.905

5. Chemically induced dominant-lethal mutations and cell killing mouse oocytes in the advanced stages of follicular development.

Authors: W M Generoso; S W Huff; S K Stout
Journal: Mutat Res Date: 1971-04 Impact factor: 2.433

6. Strain and sex variations in the sensitivity of mice to dominant-lethal induction with ethyl methanesulfonate.

Authors: W M Generoso; W L Russell
Journal: Mutat Res Date: 1969 Nov-Dec Impact factor: 2.433

7. Ultraviolet-light-induced unscheduled DNA synthesis by resting and growing mouse oocytes.

Authors: R A Pedersen; F Mangia
Journal: Mutat Res Date: 1978-03 Impact factor: 2.433

8. [The mutagenic effect of thioTEPA in laboratory mice. V. The influence of female genotype on the realization of dominant lethal mutations induced in male spermatids].

Authors: A M Malashenko; N I Surkova
Journal: Genetika Date: 1975

8 in total

17 in total

Review 1. Evolutionary consequences of nonrandom damage and repair of chromatin domains.

Authors: T Boulikas
Journal: J Mol Evol Date: 1992-08 Impact factor: 2.395

2. A novel method for detection of chromosomal integrity in cryopreserved livestock spermatozoa using artificially fused mouse oocytes.

Authors: Hiroyuki Watanabe; Hiroshi Suzuki; Hiroyuki Tateno; Yutaka Fukui
Journal: J Assist Reprod Genet Date: 2010-06-04 Impact factor: 3.412

3. Repair of human sperm chromosome aberrations in the hamster egg.

Authors: A Genescà; M R Caballín; R Miró; J Benet; J R Germà; J Egozcue
Journal: Hum Genet Date: 1992-05 Impact factor: 4.132

4. Comparison of the genetic effects of equimolar doses of ENU and MNU: while the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia.

Authors: Liane B Russell; Patricia R Hunsicker; William L Russell
Journal: Mutat Res Date: 2006-12-14 Impact factor: 2.433

Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.

1. EMBRYONIC LETHALITY OF VARIOUS MOUSE STRAINS AS A CONSEQUENCE OF X-IRRADIATION-INDUCED INJURIES OF THE FATHER'S SPERMATOZOA.

2. Radiation dose rate and mutation frequency.

3. Ultraviolet light-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation.

4. Changing levels of uv light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation.

5. Chemically induced dominant-lethal mutations and cell killing mouse oocytes in the advanced stages of follicular development.

6. Strain and sex variations in the sensitivity of mice to dominant-lethal induction with ethyl methanesulfonate.

7. Ultraviolet-light-induced unscheduled DNA synthesis by resting and growing mouse oocytes.

8. [The mutagenic effect of thioTEPA in laboratory mice. V. The influence of female genotype on the realization of dominant lethal mutations induced in male spermatids].

Review 1. Evolutionary consequences of nonrandom damage and repair of chromatin domains.

2. A novel method for detection of chromosomal integrity in cryopreserved livestock spermatozoa using artificially fused mouse oocytes.

3. Repair of human sperm chromosome aberrations in the hamster egg.

4. Comparison of the genetic effects of equimolar doses of ENU and MNU: while the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia.

5. Heterogeneity in the human erythrocyte band 3 anion-transporter revealed by Triton X-114 phase partitioning.

6. High frequency of mosaic mutants produced by N-ethyl-N-nitrosourea exposure of mouse zygotes.

7. Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations.

8. Developmental fate of a human insulin gene in a transgenic mouse.

Review 9. DNA repair fidelity in stem cell maintenance, health, and disease.

10. Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations.