| Literature DB >> 2227933 |
A Genescà1, J Benet, M R Caballín, R Miró, J R Germà, J Egozcue.
Abstract
A significant increase in the incidence of structural chromosome anomalies has been observed in the sperm of patients treated with radio and/or chemotherapy for different types of cancer when analyzed by the interspecific fertilization of hamster eggs. The analysis of these aberrations shows that while in controls only 9.4% of structural abnormalities are of the stable type, in treated patients this figure increases to 39.3%, thus indicating that the anomalies have not been produced during the fertilization of the hamster egg. However, it is possible that part, or even most, of the breaks appear as a result of a reduced repair capacity of sperm chromosomes in the cytoplasm of the hamster egg.Entities:
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Year: 1990 PMID： 2227933 DOI： 10.1007/bf00194223
Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132