Literature DB >> 28435091

Antimicrobial peptides: Role in human disease and potential as immunotherapies.

César de la Fuente-Núñez1, Osmar N Silva2, Timothy K Lu1, Octavio Luiz Franco3.   

Abstract

Antimicrobial peptides (AMPs) have evolved through billions of years as part of our innate immune system. These agents are produced by various cells throughout the human body and play important roles in our ability to respond to infections. In this review, we outline evidence linking AMP expression with a range of inflammatory and autoimmune human diseases. Finally, we highlight the promise of endogenous AMP induction for the treatment of disease (i.e., host-directed therapy) and briefly mention the different peptide drugs that are currently undergoing clinical trials.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Antibiotic resistance; Antimicrobial peptides (AMPs); Host-directed therapy; Immune modulation; Infectious diseases; Inflammation; Synthetic peptides; Vitamin D

Mesh：

Substances：

Year:  2017        PMID： 28435091     DOI： 10.1016/j.pharmthera.2017.04.002

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  27 in total

1.  Linearized teixobactin is inactive and after sequence enhancement, kills methicillin-resistant Staphylococcus aureus via a different mechanism.

Authors:  Qianhui Wu; Biswajit Mishra; Guangshun Wang
Journal:  Pept Sci (Hoboken)       Date:  2022-04-25

2.  Proteomic Screening for Prediction and Design of Antimicrobial Peptides with AmpGram.

Authors:  Michał Burdukiewicz; Katarzyna Sidorczuk; Dominik Rafacz; Filip Pietluch; Jarosław Chilimoniuk; Stefan Rödiger; Przemysław Gagat
Journal:  Int J Mol Sci       Date:  2020-06-17       Impact factor: 5.923

3.  Cationic Amphipathic Antimicrobial Peptides Perturb the Inner Membrane of Germinated Spores Thus Inhibiting Their Outgrowth.

Authors:  Soraya Omardien; Jan Wouter Drijfhout; Sebastian A Zaat; Stanley Brul
Journal:  Front Microbiol       Date:  2018-09-26       Impact factor: 5.640

4.  Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells.

Authors:  Xiaolei Liang; Ruirui Wang; Wenshan Dou; Li Zhao; Lanxia Zhou; Junfang Zhu; Kairong Wang; Jiexi Yan
Journal:  Drug Des Devel Ther       Date:  2018-10-31       Impact factor: 4.162

Review 5.  Antiviral Activities of Human Host Defense Peptides.

Authors:  David C Brice; Gill Diamond
Journal:  Curr Med Chem       Date:  2020       Impact factor: 4.530

6.  AIPpred: Sequence-Based Prediction of Anti-inflammatory Peptides Using Random Forest.

Authors:  Balachandran Manavalan; Tae H Shin; Myeong O Kim; Gwang Lee
Journal:  Front Pharmacol       Date:  2018-03-27       Impact factor: 5.810

Review 7.  Expression and Roles of Antimicrobial Peptides in Innate Defense of Airway Mucosa: Potential Implication in Cystic Fibrosis.

Authors:  Regina Geitani; Carole Ayoub Moubareck; Zhengzhong Xu; Dolla Karam Sarkis; Lhousseine Touqui
Journal:  Front Immunol       Date:  2020-06-30       Impact factor: 7.561

Review 8.  Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy.

Authors:  Derry K Mercer; Marcelo D T Torres; Searle S Duay; Emma Lovie; Laura Simpson; Maren von Köckritz-Blickwede; Cesar de la Fuente-Nunez; Deborah A O'Neil; Alfredo M Angeles-Boza
Journal:  Front Cell Infect Microbiol       Date:  2020-07-07       Impact factor: 5.293

Review 9.  Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries.

Authors:  Ana Gomes; Cátia Teixeira; Ricardo Ferraz; Cristina Prudêncio; Paula Gomes
Journal:  Molecules       Date:  2017-10-18       Impact factor: 4.411

Review 10.  The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs.

Authors:  Alicia Boto; Jose Manuel Pérez de la Lastra; Concepción C González
Journal:  Molecules       Date:  2018-02-01       Impact factor: 4.411
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