Literature DB >> 2843467

Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae.

T F Murphy1, L C Bartos.   

Abstract

The human bactericidal antibody response to the major outer membrane protein, P2, of nontypeable Haemophilus influenzae was studied. P2 was isolated from two strains of nontypeable H. influenzae and coupled to affinity columns. Pooled normal human serum was subjected to affinity chromatography with the P2 columns and a control column. Reducing the titer of antibody to P2 resulted in reduced bactericidal activity of that serum for the organism. Immunopurified antibody to P2 from human serum was bactericidal for the homologous strain. The extent to which these bactericidal determinants on P2 are conserved among strains was investigated. Immunopurified antibodies to P2 of two epidemiologically unrelated isolates were bactericidal for four of six strains tested. We conclude that P2 is a target for human bactericidal antibody and that some of these determinants that are recognized by human bactericidal antibody are conserved among strains of nontypeable H. influenzae.

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Year:  1988        PMID： 2843467      PMCID： PMC259628          DOI： 10.1128/iai.56.10.2673-2679.1988

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  32 in total

1.  Purification and analysis with monoclonal antibodies of P2, the major outer membrane protein of nontypable Haemophilus influenzae.

Authors:  T F Murphy; L C Bartos
Journal:  Infect Immun       Date:  1988-05       Impact factor: 3.441

2.  Bacterial etiology of otitis media during the first six weeks of life.

Authors:  P A Shurin; V M Howie; S I Pelton; J H Ploussard; J O Klein
Journal:  J Pediatr       Date:  1978-06       Impact factor: 4.406

3.  Acute otitis media in children. Bacteriological findings in middle ear fluid obtained by needle aspiration.

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Journal:  Am J Dis Child       Date:  1966-04

4.  Typing of Haemophilus influenzae by counterimmunoelectrophoresis.

Authors:  E B Myhre
Journal:  Acta Pathol Microbiol Scand B Microbiol Immunol       Date:  1974-04

5.  Acute otitis media: treatment results in relation to bacterial etiology.

Authors:  B W Nilson; R L Poland; R S Thompson; D Morehead; A Baghdassarian; D H Carver
Journal:  Pediatrics       Date:  1969-03       Impact factor: 7.124

6.  Serum bactericidal effect on capsulated and non-capsulated Haemophilus influenzae.

Authors:  P Branefors; T Dahlberg
Journal:  Acta Pathol Microbiol Scand C       Date:  1980-02

7.  Subtyping isolates of Haemophilus influenzae type b by outer-membrane protein profiles.

Authors:  S J Barenkamp; R S Munson; D M Granoff
Journal:  J Infect Dis       Date:  1981-05       Impact factor: 5.226

8.  Outer membrane protein composition in disease isolates of Haemophilus influenzae: pathogenic and epidemiological implications.

Authors:  M R Loeb; D H Smith
Journal:  Infect Immun       Date:  1980-12       Impact factor: 3.441

9.  Bactericidal antibody and susceptibility to otitis media caused by nontypable strains of Haemophilus influenzae.

Authors:  P A Shurin; S I Pelton; I B Tager; D L Kasper
Journal:  J Pediatr       Date:  1980-09       Impact factor: 4.406

10.  Human immunity to the meningococcus. I. The role of humoral antibodies.

Authors:  I Goldschneider; E C Gotschlich; M S Artenstein
Journal:  J Exp Med       Date:  1969-06-01       Impact factor: 14.307
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  40 in total

1.  Immune response to Haemophilus parainfluenzae in patients with chronic obstructive lung disease.

Authors:  J L Mitchell; S L Hill
Journal:  Clin Diagn Lab Immunol       Date:  2000-01

2.  Antibodies specific for the high-molecular-weight adhesion proteins of nontypeable Haemophilus influenzae are opsonophagocytic for both homologous and heterologous strains.

Authors:  Linda E Winter; Stephen J Barenkamp
Journal:  Clin Vaccine Immunol       Date:  2006-10-04

3.  Discovery and Contribution of Nontypeable Haemophilus influenzae NTHI1441 to Human Respiratory Epithelial Cell Invasion.

Authors:  C P Ahearn; C Kirkham; L D Chaves; Y Kong; M M Pettigrew; T F Murphy
Journal:  Infect Immun       Date:  2019-10-18       Impact factor: 3.441

4.  Mapping of bactericidal epitopes on the P2 porin protein of nontypeable Haemophilus influenzae.

Authors:  E M Haase; K Yi; G D Morse; T F Murphy
Journal:  Infect Immun       Date:  1994-09       Impact factor: 3.441

5.  Outer membrane protein binding sites of complement component 3 during opsonization of Haemophilus influenzae.

Authors:  S V Hetherington; C C Patrick; E J Hansen
Journal:  Infect Immun       Date:  1993-12       Impact factor: 3.441

6.  Reconstitution of a porin-deficient mutant of Haemophilus influenzae type b with a porin gene from nontypeable H. influenzae.

Authors:  J D Sanders; L D Cope; G P Jarosik; I Maciver; J L Latimer; G B Toews; E J Hansen
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

7.  Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates.

Authors:  J Bell; S Grass; D Jeanteur; R S Munson
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441

8.  Cloning, expression, and DNA sequence analysis of genes encoding nontypeable Haemophilus influenzae high-molecular-weight surface-exposed proteins related to filamentous hemagglutinin of Bordetella pertussis.

Authors:  S J Barenkamp; E Leininger
Journal:  Infect Immun       Date:  1992-04       Impact factor: 3.441

9.  Molecular cloning and sequence analysis of the gene encoding OmpL1, a transmembrane outer membrane protein of pathogenic Leptospira spp.

Authors:  D A Haake; C I Champion; C Martinich; E S Shang; D R Blanco; J N Miller; M A Lovett
Journal:  J Bacteriol       Date:  1993-07       Impact factor: 3.490

10.  Lipooligosaccharides containing phosphorylcholine delay pulmonary clearance of nontypeable Haemophilus influenzae.

Authors:  Bing Pang; Dana Winn; Ryan Johnson; Wenzhou Hong; Shayla West-Barnette; Nancy Kock; W Edward Swords
Journal:  Infect Immun       Date:  2008-03-17       Impact factor: 3.441
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