Xiaochuan Xie1, Xiaohan Shi2, Peng Chen3, Li Rao4. 1. Department of Cardiology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. 2. Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. 3. Laboratory of Molecular Translational Medicine, West China Second University Hospital of Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. 4. Department of Cardiology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. raoli8866@163.com.
Abstract
PURPOSE: Recently, the roles of TIM-1 genetic polymorphisms in asthma have been extensively studied, with conflicting results. Therefore, we performed the present meta-analysis to better assess potential associations of TIM-1 genetic polymorphisms with asthma. METHODS: Eligible articles were searched in PubMed, Medline, EMBASE, Google Scholar, and CNKI up to December 2016. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between TIM-1 genetic polymorphisms and asthma. RESULTS: A total of 12 articles including 3120 asthma patients and 2825 control subjects were analyzed. The overall and subgroup analyses revealed that TIM-1-416G>C single nucleotide polymorphism was significantly associated with asthma for the Asian population in the codominant (G/G vs. G/C, p = 0.0003, OR 1.86, 95% CI 1.33-2.60) and dominant (G/G vs. G/C + C/C, p < 0.0001, OR 1.94, 95% CI 1.40-2.69) genetic models. Nevertheless, we failed to detect any significant associations between TIM-1-416G>C single nucleotide polymorphism and asthma in Caucasians. Additionally, according to our analyses, TIM-1 5383_5397 insertion/deletion polymorphism was not correlated with asthma in both Asians and Caucasians. CONCLUSIONS: In conclusion, our findings suggest that TIM-1-416G>C single nucleotide polymorphism is associated with asthma susceptibility for the Asian ethnicity in certain genetic models. However, TIM-1 5383_5397 insertion/deletion polymorphism may not be correlated with the risk of asthma.
PURPOSE: Recently, the roles of TIM-1 genetic polymorphisms in asthma have been extensively studied, with conflicting results. Therefore, we performed the present meta-analysis to better assess potential associations of TIM-1 genetic polymorphisms with asthma. METHODS: Eligible articles were searched in PubMed, Medline, EMBASE, Google Scholar, and CNKI up to December 2016. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between TIM-1 genetic polymorphisms and asthma. RESULTS: A total of 12 articles including 3120 asthmapatients and 2825 control subjects were analyzed. The overall and subgroup analyses revealed that TIM-1-416G>C single nucleotide polymorphism was significantly associated with asthma for the Asian population in the codominant (G/G vs. G/C, p = 0.0003, OR 1.86, 95% CI 1.33-2.60) and dominant (G/G vs. G/C + C/C, p < 0.0001, OR 1.94, 95% CI 1.40-2.69) genetic models. Nevertheless, we failed to detect any significant associations between TIM-1-416G>C single nucleotide polymorphism and asthma in Caucasians. Additionally, according to our analyses, TIM-1 5383_5397 insertion/deletion polymorphism was not correlated with asthma in both Asians and Caucasians. CONCLUSIONS: In conclusion, our findings suggest that TIM-1-416G>C single nucleotide polymorphism is associated with asthma susceptibility for the Asian ethnicity in certain genetic models. However, TIM-1 5383_5397 insertion/deletion polymorphism may not be correlated with the risk of asthma.
Entities:
Keywords:
Asthma; Genetic polymorphisms; Meta-analysis; T cell immunoglobulin domain and mucin domain-1 (TIM-1)
Authors: H Shirzade; R Meshkat; M Ganjalikhani-Hakemi; A Mosayebian; R Ghasemi; F Deress; S Parchami Barjui; M Sadri; R Salehi Journal: Int J Immunogenet Date: 2015-06-03 Impact factor: 1.466
Authors: E Noguchi; M Shibasaki; T Arinami; K Takeda; T Maki; T Miyamoto; T Kawashima; K Kobayashi; H Hamaguchi Journal: Am J Respir Crit Care Med Date: 1997-11 Impact factor: 21.405