Literature DB >> 12776205

The TIM gene family: emerging roles in immunity and disease.

Vijay K Kuchroo1, Dale T Umetsu, Rosemarie H DeKruyff, Gordon J Freeman.   

Abstract

The search for cell-surface markers that can distinguish T helper 1 (T(H)1) cells from T(H)2 cells has led to the identification of a new gene family, encoding the T-cell immunoglobulin mucin (TIM) proteins, some of which are differentially expressed by T(H)1 and T(H)2 cells. The role of the TIM-family proteins in immune regulation is just beginning to emerge. Here, we describe the various TIM-family members in mice and humans, and discuss the genetic and functional evidence for their role in regulating autoimmune and allergic diseases.

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Year:  2003        PMID： 12776205     DOI： 10.1038/nri1111

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  149 in total

1.  Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates.

Authors:  Hitoshi Ohtani; Taeko K Naruse; Yuki Iwasaki; Hirofumi Akari; Takafumi Ishida; Tetsuro Matano; Akinori Kimura
Journal:  Immunogenetics       Date:  2012-06-19       Impact factor: 2.846

Review 2.  Regulation of immune cell responses by semaphorins and their receptors.

Authors:  Hyota Takamatsu; Tatsusada Okuno; Atsushi Kumanogoh
Journal:  Cell Mol Immunol       Date:  2010-02-01       Impact factor: 11.530

Review 3.  TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.

Authors:  Gordon J Freeman; Jose M Casasnovas; Dale T Umetsu; Rosemarie H DeKruyff
Journal:  Immunol Rev       Date:  2010-05       Impact factor: 12.988

4.  Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.

Authors:  Sheng Xiao; Craig R Brooks; Chen Zhu; Chuan Wu; Johanna M Sweere; Sonia Petecka; Ada Yeste; Francisco J Quintana; Takaharu Ichimura; Raymond A Sobel; Joseph V Bonventre; Vijay K Kuchroo
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-05       Impact factor: 11.205

5.  The CD68(+)/H-ferritin(+) cells colonize the lymph nodes of the patients with adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue: correlation with disease severity and implication for pathogenesis.

Authors:  P Ruscitti; F Ciccia; P Cipriani; G Guggino; P Di Benedetto; A Rizzo; V Liakouli; O Berardicurti; F Carubbi; G Triolo; R Giacomelli
Journal:  Clin Exp Immunol       Date:  2015-12-08       Impact factor: 4.330

6.  Interactions of human T cell immunoglobin mucins with apoptotic cells.

Authors:  Zhizhong Chen; Jilin Qing; Lihua Hu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2012-01-27

Review 7.  Cellular and mitochondrial iron homeostasis in vertebrates.

Authors:  Caiyong Chen; Barry H Paw
Journal:  Biochim Biophys Acta       Date:  2012-01-18

8.  Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma.

Authors:  Won K Han; Anwar Alinani; Chin-Lee Wu; Dror Michaelson; Massimo Loda; Francis J McGovern; Ravi Thadhani; Joseph V Bonventre
Journal:  J Am Soc Nephrol       Date:  2005-03-02       Impact factor: 10.121

9.  Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: role in hepatitis B vaccine failure during hepatitis C infection.

Authors:  Jia M Wang; Cheng J Ma; Guang Y Li; Xiao Y Wu; Penny Thayer; Pamela Greer; Ashley M Smith; Kevin P High; Jonathan P Moorman; Zhi Q Yao
Journal:  Vaccine       Date:  2013-03-14       Impact factor: 3.641

10.  T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase.

Authors:  Anjali J de Souza; Jean S Oak; Ryan Jordanhazy; Rosemarie H DeKruyff; David A Fruman; Lawrence P Kane
Journal:  J Immunol       Date:  2008-05-15       Impact factor: 5.422
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