Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor.

Literature DB >> 2843283

Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor.

G R Elliott¹, C Tak, C Pellens, S Ben-Efraim, I L Bonta.

Abstract

Indomethacin enhanced macrophage cytostasis against MOPC-315 tumor cells in vitro. The effect of indomethacin was inhibited by prostaglandin E2 and by the lipoxygenase inhibitor nordihydroguaiaretic acid. Prostaglandin E2 and nordihydroguaiaretic acid also inhibited indomethacin stimulation of macrophage thymidine incorporation. Indomethacin inhibited macrophage prostaglandin E2 formation and stimulated leukotriene B4 synthesis. Nordihydroguaiaretic acid inhibited leukotriene B4 production. Our data indicate that eicosanoids play a role in regulating macrophage cytostasis.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1988 PMID： 2843283 DOI： 10.1007/BF00200017

Source DB: PubMed Journal: Cancer Immunol Immunother ISSN： 0340-7004 Impact factor: 6.968

11 in total

1. Biochemical characterization of a factor released by macrophages.

Authors: H G Opitz; D Niethammer; R C Jackson; H Lemke; R Huget; H D Flad
Journal: Cell Immunol Date: 1975-07 Impact factor: 4.868

2. Prostaglandins as endogenous mediators of interleukin 1 production.

Authors: S L Kunkel; S W Chensue; S H Phan
Journal: J Immunol Date: 1986-01 Impact factor: 5.422

3. Cyclooxygenase inhibitors promote the leukotriene C4 induced release of beta-glucuronidase from rat peritoneal macrophages: prostaglandin E2 suppresses.

Authors: E J Schenkelaars; I L Bonta
Journal: Int J Immunopharmacol Date: 1986

4. Characterization of macrophage subpopulations responsive to activation by endotoxin and lymphokines.

Authors: K C Lee; M Wong; D McIntyre
Journal: J Immunol Date: 1981-06 Impact factor: 5.422

5. Human natural cytotoxic cell activity: enhancement by leukotrienes (LT) A4, B4 and D4, but not by stereoisomers of LTB4 or HETES.

Authors: M Rola-Pleszczynski; L Gagnon; M Rudzinska; P Borgeat; P Sirois
Journal: Prostaglandins Leukot Med Date: 1984-01

6. Leukotriene D4 and indomethacin enhance additively the macrophage cytostatic activity in vitro towards MOPC-315 tumour cells.

Authors: R Ophir; S Ben-Efraim; I L Bonta
Journal: Int J Tissue React Date: 1987

7. Induction of macrophage growth by lipids.

Authors: S Yui; M Yamazaki
Journal: J Immunol Date: 1986-02-15 Impact factor: 5.422

8. Leukotrienes augment interleukin 1 production by human monocytes.

Authors: M Rola-Pleszczynski; I Lemaire
Journal: J Immunol Date: 1985-12 Impact factor: 5.422

9. Chemiluminescence from mouse resident macrophages: characterization and modulation by arachidonate metabolites.

Authors: M J Parnham; C Bittner; J Winkelmann
Journal: Immunopharmacology Date: 1983-04

10. Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.

Authors: E A Ham; D D Soderman; M E Zanetti; H W Dougherty; E McCauley; F A Kuehl
Journal: Proc Natl Acad Sci U S A Date: 1983-07 Impact factor: 11.205

4 in total

1. Influence of zymosan (a non-specific macrophage stimulator) and of indomethacin on liver tumours--an experimental study in rats.

Authors: S B Holmberg; P L Naredi; G O Lindnér; I H Karlberg; P L Daneryd; L M Karlsson; A Pettersson; U Stenram; L R Hafström
Journal: J Cancer Res Clin Oncol Date: 1995 Impact factor: 4.553