Moawia Mohammed Ali Elhassan1, Haytham Hussein Mohammed Osman2, Jeannette Parkes3. 1. National Cancer institute, University of Gezira, P.O Box 20, Wad Madani, Sudan. moawia2@gmail.com. 2. Rebat University, Khartoum, Sudan. 3. Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Abstract
BACKGROUND: Posterior cranial fossa tumours (PCF) comprise 54-70% of childhood brain tumours. The clinical profile and outcomes of these tumours differ in area of the world. The aim of this study is to describe clinical characteristics, treatment and outcome of posterior cranial fossa tumours in Sudan. MATERIAL AND METHODS: A retrospective study of children diagnosed with posterior cranial fossa tumours and treated between January 1998 and December 2015 at National Cancer Institute, Sudan. RESULTS: A total of 31 paediatric patients with a posterior cranial fossa brain tumour were identified over the study period. The mean age was 7.9 years (standard deviation (SD) = 3.37). Females were slightly more affected (51%) than males (49%), and the majority of patients were from rural areas (71%). Brainstem tumours were the most frequent tumour type (48%) followed by medulloblastoma (36%). The mean pre-diagnostic symptomatic interval was 3.6 months (SD = 3.95). Overall survival rate of our total study population at 1, 2 and 5 years was 23, 19 and 13%, respectively. CONCLUSION: Overall, this study draws attention to the situation of paediatric brain tumours in Sudan. Late presentation, misdiagnosis and limited diagnostic and treatment resources are challenges that may contribute to poor outcome in these patients.
BACKGROUND:Posterior cranial fossa tumours (PCF) comprise 54-70% of childhood brain tumours. The clinical profile and outcomes of these tumours differ in area of the world. The aim of this study is to describe clinical characteristics, treatment and outcome of posterior cranial fossa tumours in Sudan. MATERIAL AND METHODS: A retrospective study of children diagnosed with posterior cranial fossa tumours and treated between January 1998 and December 2015 at National Cancer Institute, Sudan. RESULTS: A total of 31 paediatric patients with a posterior cranial fossa brain tumour were identified over the study period. The mean age was 7.9 years (standard deviation (SD) = 3.37). Females were slightly more affected (51%) than males (49%), and the majority of patients were from rural areas (71%). Brainstem tumours were the most frequent tumour type (48%) followed by medulloblastoma (36%). The mean pre-diagnostic symptomatic interval was 3.6 months (SD = 3.95). Overall survival rate of our total study population at 1, 2 and 5 years was 23, 19 and 13%, respectively. CONCLUSION: Overall, this study draws attention to the situation of paediatric brain tumours in Sudan. Late presentation, misdiagnosis and limited diagnostic and treatment resources are challenges that may contribute to poor outcome in these patients.
Authors: Jeannette Parkes; Marc Hendricks; Peter Ssenyonga; John Mugamba; Elizabeth Molyneux; Antoinette Schouten-van Meeteren; Ibrahim Qaddoumi; Graham Fieggen; Sandra Luna-Fineman; Scott Howard; Dipayan Mitra; Eric Bouffet; Alan Davidson; Simon Bailey Journal: Pediatr Blood Cancer Date: 2014-11-21 Impact factor: 3.167
Authors: F Gjerris; N Agerlin; S E Børgesen; L Buhl; J Haase; L Klinken; A C Mortensen; J H Olsen; N Ovesen; E Reske-Nielsen; K Schmidt Journal: Childs Nerv Syst Date: 1998-07 Impact factor: 1.475
Authors: M Mohammed Ali Elhassan; A Abdalla Mohamedani; H Hussein Mohammed Osman; N Osman Yousif; N Mohamed Elhaj; I Qaddoumi Journal: Childs Nerv Syst Date: 2019-01-04 Impact factor: 1.475