| Literature DB >> 28431812 |
Akihiro Nakatsukasa1, Koji Kuruma2, Masatoshi Okamatsu1, Takahiro Hiono1, Mizuho Suzuki1, Keita Matsuno3, Hiroshi Kida4, Takayoshi Oyamada2, Yoshihiro Sakoda5.
Abstract
Transdermal vaccination using a microneedle (MN) confers enhanced immunity compared with subcutaneous (SC) vaccination. Here we developed a novel dissolving MN patch for the influenza vaccine. The potencies of split virion and whole virus particle (WVP) vaccines prepared from A/Puerto Rico/8/1934 (H1N1) and A/duck/Hokkaido/Vac-3/2007 (H5N1), respectively, were evaluated. MN vaccination induced higher neutralizing antibody responses than SC vaccination in mice. Moreover, MN vaccination with a lower dose of antigens conferred protective immunity against lethal challenges of influenza viruses than SC vaccination in mice. These results suggest that the WVP vaccines administered using MN are an effective combination for influenza vaccine to be further validated in humans.Entities:
Keywords: Dissolving microneedle; Influenza; Split virion; Transdermal vaccination; Vaccine; Whole virus particle
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Year: 2017 PMID： 28431812 DOI： 10.1016/j.vaccine.2017.04.009
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641