| Literature DB >> 2843087 |
H Aoyama1, K Fujimaki, K Sato, T Fujii, M Inoue, K Hirai, S Mitsuhashi.
Abstract
About 30% of 150 recent clinical isolates of Citrobacter freundii were resistant to greater than or equal to 3.13 micrograms of norfloxacin and ofloxacin per ml. Study of one quinolone-resistant strain for which the norfloxacin MIC was 100 micrograms/ml suggested that resistance was associated with both an altered A subunit of DNA gyrase and reduction in drug uptake accompanied by a decrease in an outer membrane protein.Entities:
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Year: 1988 PMID: 2843087 PMCID: PMC172307 DOI: 10.1128/AAC.32.6.922
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191