| Literature DB >> 28430430 |
Linlin Qin1, Lei Ren1, Songlin Wan1, Guoliang Liu1, Xinfeng Luo1, Zhenhong Liu1, Fangqiong Li1, Yan Yu1, Jianyu Liu1, Yonggang Wei1.
Abstract
A novel series of optically active 2,6-disubstituted alkylphenols with improved anesthetic profiles compared to widely used propofol were synthesized. The incorporation of the cyclopropyl group not only increased the steric effect but also introduced stereoselective effects over their anesthetic properties. Compounds 1, 2, and 6 were selected as potential candidates for further preclinical development including studies of their water-soluble prodrugs. Clinical studies of candidate compound 6 (Haisco HSK3486) as a general anesthetic are being performed in Australia and China.Entities:
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Year: 2017 PMID： 28430430 DOI： 10.1021/acs.jmedchem.7b00254
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446