Literature DB >> 28429766

Beyond growth signaling: Paneth cells metabolically support ISCs.

Talya L Dayton1, Hans Clevers1.   

Abstract

Single Lgr5 intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or "mini-guts", self-organizing cellular structures that recreate the intestinal differentiation program; Paneth cells, which constitute the intestinal stem cell niche, secrete stem cell growth signals, and are thus essential for this process. In a recent paper published in Nature, Rodríguez-Colman et al. describe how Paneth cells may be supporting the metabolic state of ISCs.

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Year:  2017        PMID： 28429766      PMCID： PMC5518985          DOI： 10.1038/cr.2017.59

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  12 in total

Review 1.  Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.

Authors:  Sophia Y Lunt; Matthew G Vander Heiden
Journal:  Annu Rev Cell Dev Biol       Date:  2011       Impact factor: 13.827

2.  Interplay between metabolic identities in the intestinal crypt supports stem cell function.

Authors:  Maria J Rodríguez-Colman; Matthias Schewe; Maaike Meerlo; Edwin Stigter; Johan Gerrits; Mia Pras-Raves; Andrea Sacchetti; Marten Hornsveld; Koen C Oost; Hugo J Snippert; Nanda Verhoeven-Duif; Riccardo Fodde; Boudewijn M T Burgering
Journal:  Nature       Date:  2017-03-08       Impact factor: 49.962

Review 3.  Paneth cells: maestros of the small intestinal crypts.

Authors:  Hans C Clevers; Charles L Bevins
Journal:  Annu Rev Physiol       Date:  2013       Impact factor: 19.318

Review 4.  Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors.

Authors:  Daniel E Stange; Hans Clevers
Journal:  Stem Cells       Date:  2013-11       Impact factor: 6.277

5.  Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Authors:  Toshiro Sato; Johan H van Es; Hugo J Snippert; Daniel E Stange; Robert G Vries; Maaike van den Born; Nick Barker; Noah F Shroyer; Marc van de Wetering; Hans Clevers
Journal:  Nature       Date:  2010-11-28       Impact factor: 49.962

6.  Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.

Authors:  Heather A Hirsch; Dimitrios Iliopoulos; Philip N Tsichlis; Kevin Struhl
Journal:  Cancer Res       Date:  2009-09-14       Impact factor: 12.701

7.  Metabolic plasticity in stem cell homeostasis and differentiation.

Authors:  Clifford D L Folmes; Petras P Dzeja; Timothy J Nelson; Andre Terzic
Journal:  Cell Stem Cell       Date:  2012-11-02       Impact factor: 24.633

8.  Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells.

Authors:  Alexander Roesch; Adina Vultur; Ivan Bogeski; Huan Wang; Katharina M Zimmermann; David Speicher; Christina Körbel; Matthias W Laschke; Phyllis A Gimotty; Stephan E Philipp; Elmar Krause; Sylvie Pätzold; Jessie Villanueva; Clemens Krepler; Mizuho Fukunaga-Kalabis; Markus Hoth; Boris C Bastian; Thomas Vogt; Meenhard Herlyn
Journal:  Cancer Cell       Date:  2013-06-10       Impact factor: 31.743

Review 9.  Hallmarks of cancer stem cell metabolism.

Authors:  Patricia Sancho; David Barneda; Christopher Heeschen
Journal:  Br J Cancer       Date:  2016-05-24       Impact factor: 7.640

10.  High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.

Authors:  Semir Beyaz; Miyeko D Mana; Jatin Roper; Dmitriy Kedrin; Assieh Saadatpour; Sue-Jean Hong; Khristian E Bauer-Rowe; Michael E Xifaras; Adam Akkad; Erika Arias; Luca Pinello; Yarden Katz; Shweta Shinagare; Monther Abu-Remaileh; Maria M Mihaylova; Dudley W Lamming; Rizkullah Dogum; Guoji Guo; George W Bell; Martin Selig; G Petur Nielsen; Nitin Gupta; Cristina R Ferrone; Vikram Deshpande; Guo-Cheng Yuan; Stuart H Orkin; David M Sabatini; Ömer H Yilmaz
Journal:  Nature       Date:  2016-03-03       Impact factor: 49.962
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  2 in total

1.  Second-generation Probiotics Producing IL-22 Increase Survival of Mice After Total Body Irradiation.

Authors:  Xichen Zhang; Renee Fisher; Wen Hou; Donna Shields; Michael W Epperly; Hong Wang; Liang Wei; Brian J Leibowitz; Jian Yu; Laura M Alexander; Jan-Peter VAN Pijkeren; Simon Watkins; Peter Wipf; Joel S Greenberger
Journal:  In Vivo       Date:  2020 Jan-Feb       Impact factor: 2.155

2.  Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling.

Authors:  Aimin Wu; Bing Yu; Keying Zhang; Zhiwen Xu; Jun He; Junqiu Luo; Yuheng Luo; Jie Yu; Ping Zheng; Lianqiang Che; Xiangbing Mao; Zhiqing Huang; Lan Wang; Jun Zhao; Daiwen Chen
Journal:  Cell Death Dis       Date:  2020-01-20       Impact factor: 8.469
  2 in total

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