Literature DB >> 2842896

Side-chain hydroxylation of vitamin D3 and its physiological implications.

G Jones1, D Vriezen, D Lohnes, V Palda, N S Edwards.   

Abstract

Evidence is accumulating that, in vivo and in vitro, both 25-OH-D3 and 1,25-(OH)2D3 undergo side-chain modification leading to side-chain cleaved metabolites lacking the 24, 25, 26, and 27 carbons. The enzymes involved are D-dependent and are located in the kidney, bone, intestine, and perhaps other sites. We speculate that the extra-renal side-chain pathway may be primarily for target organ destruction of 1,25-(OH)2D3, whereas the renal pathway may be primarily for destruction of 25-OH-D3 formed in large amounts in hypervitaminosis D.

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Year:  1987        PMID： 2842896     DOI： 10.1016/0039-128x(87)90078-x

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  10 in total

1.  Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation.

Authors:  G Makin; D Lohnes; V Byford; R Ray; G Jones
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

Review 2.  Cytochrome P450-mediated metabolism of vitamin D.

Authors:  Glenville Jones; David E Prosser; Martin Kaufmann
Journal:  J Lipid Res       Date:  2013-04-06       Impact factor: 5.922

3.  PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation.

Authors:  Holly P Quach; Qi J Yang; Edwin C Chow; Donald E Mager; Stacie Y Hoi; K Sandy Pang
Journal:  Br J Pharmacol       Date:  2015-05-15       Impact factor: 8.739

4.  Cholecalciferol supplementation in hemodialysis patients: effects on mineral metabolism, inflammation, and cardiac dimension parameters.

Authors:  Patrícia João Matias; Cristina Jorge; Carina Ferreira; Marília Borges; Inês Aires; Tiago Amaral; Célia Gil; José Cortez; Aníbal Ferreira
Journal:  Clin J Am Soc Nephrol       Date:  2010-03-04       Impact factor: 8.237

5.  The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis.

Authors:  Hugo Vanden Bossche; Jannie Ausma; Hilde Bohets; Karen Vermuyten; Gustaaf Willemsens; Patrick Marichal; Lieven Meerpoel; Frank Odds; Marcel Borgers
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

6.  The gene for X-linked hypophosphataemic rickets maps to a 200-300kb region in Xp22.1, and is located on a single YAC containing a putative vitamin D response element (VDRE).

Authors:  P S Rowe; J N Goulding; F Francis; C Oudet; M J Econs; A Hanauer; H Lehrach; A P Read; R C Mountford; T Summerfield; J Weissenbach; W Fraser; M K Drezner; K E Davies; J L O'Riordan
Journal:  Hum Genet       Date:  1996-03       Impact factor: 4.132

Review 7.  Molecular biology of hypophosphataemic rickets and oncogenic osteomalacia.

Authors:  P S Rowe
Journal:  Hum Genet       Date:  1994-11       Impact factor: 4.132

Review 8.  Renal adaptation to phosphate deprivation: lessons from the X-linked Hyp mouse.

Authors:  H S Tenenhouse; J Martel
Journal:  Pediatr Nephrol       Date:  1993-06       Impact factor: 3.714

9.  1α,25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor.

Authors:  Ferdinand Molnár; Rita Sigüeiro; Yoshiteru Sato; Clarisse Araujo; Inge Schuster; Pierre Antony; Jean Peluso; Christian Muller; Antonio Mouriño; Dino Moras; Natacha Rochel
Journal:  PLoS One       Date:  2011-03-31       Impact factor: 3.240

Review 10.  Diagnostic Aspects of Vitamin D: Clinical Utility of Vitamin D Metabolite Profiling.

Authors:  Glenville Jones; Martin Kaufmann
Journal:  JBMR Plus       Date:  2021-12-03
  10 in total

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