Literature DB >> 28425074

LincRNa-p21: function and mechanism in cancer.

Shaoyun Chen1, Hairong Liang1, Hui Yang1, Kairu Zhou1, Longmei Xu1, Jiaxian Liu1, Bei Lai1, Li Song1, Hao Luo1, Jianming Peng2, Zhidong Liu2, Yongmei Xiao3, Wen Chen3, Huanwen Tang4.   

Abstract

In view of the rapid development of gene chips and high-throughput sequencing technology, noncoding RNAs (ncRNas) form a high percentage of the mammalian genome. Two major subgroups of ncRNAs that have been identified are the long ncRNAs (lncRNas) and the microRNAs. A number of studies in the past few years have showed crucial functions for lncRNas in cancer. LincRNa-p21 as a p53-dependent transcriptional target gene and a potential diagnostic marker is involved in proliferation, cell cycle, metabolism and reprogramming. In addition, more researches revealed that lincRNa-p21 is associated with cancer progression and contributed to the treatment and prognosis of cancer. In this review, we briefly summarize the function and molecular mechanisms of lincRNa-p21 in cancer and its regulation for the genes expression .

Entities:  

Keywords:  Cancer; Genes expression; LincRNa-p21; Long noncoding RNAs

Mesh：

Substances：

Year:  2017        PMID： 28425074     DOI： 10.1007/s12032-017-0959-5

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  55 in total

1.  LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity.

Authors:  Gengze Wu; Jin Cai; Yu Han; Jinghai Chen; Zhan-Peng Huang; Caiyu Chen; Yue Cai; Hefei Huang; Yujia Yang; Yukai Liu; Zaicheng Xu; Duofen He; Xiaoqun Zhang; Xiaoyun Hu; Luca Pinello; Dan Zhong; Fengtian He; Guo-Cheng Yuan; Da-Zhi Wang; Chunyu Zeng
Journal:  Circulation       Date:  2014-08-25       Impact factor: 29.690

Review 2.  On the origin of the cancer cells.

Authors:  A C Braun
Journal:  Am Sci       Date:  1970 May-Jun       Impact factor: 0.548

3.  Suppression of ING1 expression in sporadic breast cancer.

Authors:  T Toyama; H Iwase; P Watson; H Muzik; E Saettler; A Magliocco; L DiFrancesco; P Forsyth; I Garkavtsev; S Kobayashi; K Riabowol
Journal:  Oncogene       Date:  1999-09-16       Impact factor: 9.867

4.  HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

Authors:  M Ivan; K Kondo; H Yang; W Kim; J Valiando; M Ohh; A Salic; J M Asara; W S Lane; W G Kaelin
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

Review 5.  Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers.

Authors:  Bryan D White; Andy J Chien; David W Dawson
Journal:  Gastroenterology       Date:  2011-12-08       Impact factor: 22.682

Review 6.  Insights into angiogenesis in non-small cell lung cancer: molecular mechanisms, polymorphic genes, and targeted therapies.

Authors:  Ramon Andrade de Mello; Bruno M Costa; Rui M Reis; Venceslau Hespanhol
Journal:  Recent Pat Anticancer Drug Discov       Date:  2012-01       Impact factor: 4.169

7.  An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment.

Authors:  Nianwei Lin; Kung-Yen Chang; Zhonghan Li; Keith Gates; Zacharia A Rana; Jason Dang; Danhua Zhang; Tianxu Han; Chao-Shun Yang; Thomas J Cunningham; Steven R Head; Gregg Duester; P Duc Si Dong; Tariq M Rana
Journal:  Mol Cell       Date:  2014-02-13       Impact factor: 17.970

8.  Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression.

Authors:  Carla J Beckham; Jayme Olsen; Peng-Nien Yin; Chia-Hao Wu; Huei-Ju Ting; Fred K Hagen; Emelian Scosyrev; Edward M Messing; Yi-Fen Lee
Journal:  J Urol       Date:  2014-02-14       Impact factor: 7.450

Review 9.  The hallmarks of cancer: a long non-coding RNA point of view.

Authors:  Tony Gutschner; Sven Diederichs
Journal:  RNA Biol       Date:  2012-06-01       Impact factor: 4.652

10.  LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma.

Authors:  Ning Yang; Yong Fu; Haibin Zhang; Hui Sima; Nan Zhu; Guangshun Yang
Journal:  Oncotarget       Date:  2015-09-29
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  24 in total

Review 1.  Long intergenic noncoding RNAs in cardiovascular diseases: Challenges and strategies for physiological studies and translation.

Authors:  Xuan Zhang; Daniel Y Li; Muredach P Reilly
Journal:  Atherosclerosis       Date:  2018-09-29       Impact factor: 5.162

2.  Emerging roles of long non-coding RNAs in the p53 network.

Authors:  Abhinav K Jain
Journal:  RNA Biol       Date:  2020-06-04       Impact factor: 4.652

Review 3.  How long noncoding RNAs enforce their will on mitochondrial activity: regulation of mitochondrial respiration, reactive oxygen species production, apoptosis, and metabolic reprogramming in cancer.

Authors:  Boel De Paepe; Steve Lefever; Pieter Mestdagh
Journal:  Curr Genet       Date:  2017-09-06       Impact factor: 3.886

Review 4.  Long non-coding RNAs in rheumatoid arthritis.

Authors:  Zheng Li; Xingye Li; Chao Jiang; Wenwei Qian; Gary Tse; Matthew T V Chan; William K K Wu
Journal:  Cell Prolif       Date:  2017-11-07       Impact factor: 6.831

5.  The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.

Authors:  Feng-Xia Guo; Qian Wu; Pan Li; Lei Zheng; Shu Ye; Xiao-Yan Dai; Chun-Min Kang; Jing-Bo Lu; Bang-Ming Xu; Yuan-Jun Xu; Lei Xiao; Zhi-Feng Lu; Huan-Lan Bai; Yan-Wei Hu; Qian Wang
Journal:  Cell Death Differ       Date:  2019-01-25       Impact factor: 15.828

Review 6.  Extracellular vesicles in prostate cancer: a narrative review.

Authors:  Koji Hatano; Kazutoshi Fujita
Journal:  Transl Androl Urol       Date:  2021-04

7.  Differently expressed long noncoding RNAs and mRNAs in TK6 cells exposed to low dose hydroquinone.

Authors:  Shaoyun Chen; Hairong Liang; Gonghua Hu; Hui Yang; Kairu Zhou; Longmei Xu; Jiaxian Liu; Bei Lai; Li Song; Hao Luo; Jianming Peng; Zhidong Liu; Yongmei Xiao; Wen Chen; Huanwen Tang
Journal:  Oncotarget       Date:  2017-10-04

Review 8.  Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation.

Authors:  Jiaxin Chen; Shuiping Liu; Xiaotong Hu
Journal:  Cell Death Discov       Date:  2018-04-27

9.  Oncogenic long intervening noncoding RNA Linc00284 promotes c-Met expression by sponging miR-27a in colorectal cancer.

Authors:  Jun You; Jiayi Li; Chunlin Ke; Yanru Xiao; Chuanhui Lu; Fakun Huang; Yanjun Mi; Rongmu Xia; Qiyuan Li
Journal:  Oncogene       Date:  2021-05-28       Impact factor: 9.867

10.  Long noncoding RNA LINC00673 promotes the proliferation and metastasis of epithelial ovarian cancer by associating with opioid growth factor receptor.

Authors:  Tingting Zheng; Junjun Qiu; Chunbo Li; Xiaojing Lin; Xiaoyan Tang; Keqin Hua
Journal:  Onco Targets Ther       Date:  2019-08-05       Impact factor: 4.147
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