Literature DB >> 28424164

Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.

Itaru Kato1,2,3, Yoko Nishinaka2, Masahiro Nakamura4, Ayse U Akarca5, Akira Niwa2, Hiroki Ozawa1, Kenichi Yoshida6, Makiko Mori7, Dapeng Wang1,8, Makiko Morita9, Hiroo Ueno3,6, Yusuke Shiozawa10, Yuichi Shiraishi11, Satoru Miyano11,12, Rajeev Gupta1, Katsutsugu Umeda3, Kenichiro Watanabe3,13, Katsuyoshi Koh7, Souichi Adachi9, Toshio Heike3, Megumu K Saito2, Masashi Sanada14, Seishi Ogawa6, Teresa Marafioti5, Akira Watanabe4, Tatsutoshi Nakahata2, Tariq Enver1.   

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Year:  2017        PMID： 28424164      PMCID： PMC5473134          DOI： 10.1182/blood-2016-06-721712

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


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  12 in total

1.  Elevated HIF-1α expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy.

Authors:  T Matsunaga; O Imataki; E Torii; T Kameda; K Shide; H Shimoda; A Kamiunten; M Sekine; Y Taniguchi; S Yamamoto; T Hidaka; K Katayose; Y Kubuki; H Dobashi; S Bandoh; H Ohnishi; F Fukai; K Shimoda
Journal:  Leuk Res       Date:  2012-03-22       Impact factor: 3.156

Review 2.  Central nervous system disease in hematologic malignancies: historical perspective and practical applications.

Authors:  Ching-Hon Pui; Eckhard Thiel
Journal:  Semin Oncol       Date:  2009-08       Impact factor: 4.929

3.  Expression of VEGF and VEGF receptors in childhood precursor B-cell acute lymphoblastic leukemia evaluated by immunohistochemistry.

Authors:  Eva Diffner; Fredrika Gauffin; Lola Anagnostaki; Ann Nordgren; Bertil Gustafsson; Birgitta Sander; Britt Gustafsson; Jenny Liao Persson
Journal:  J Pediatr Hematol Oncol       Date:  2009-09       Impact factor: 1.289

4.  Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.

Authors:  D Shweiki; A Itin; D Soffer; E Keshet
Journal:  Nature       Date:  1992-10-29       Impact factor: 49.962

5.  HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

Authors:  Jung-whan Kim; Irina Tchernyshyov; Gregg L Semenza; Chi V Dang
Journal:  Cell Metab       Date:  2006-03       Impact factor: 27.287

6.  Genetic inhibition of vascular endothelial growth factor receptor-1 significantly inhibits the migration and proliferation of leukemia cells and increases their sensitivity to chemotherapy.

Authors:  Bing Xiu; Wenjun Zhang; Binbin Huang; Jingde Chen; Huina Lu; Jianfei Fu; Hong Xiong; Aibin Liang
Journal:  Oncol Rep       Date:  2013-03-13       Impact factor: 3.906

7.  Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia.

Authors:  Sten-Eirik W Jacobsen; Tariq Enver; Christoph Lutz; Petter S Woll; Georgina Hall; Anders Castor; Helene Dreau; Giovanni Cazzaniga; Jan Zuna; Christina Jensen; Sally A Clark; Andrea Biondi; Chris Mitchell; Helen Ferry; Anna Schuh; Veronica Buckle
Journal:  Leukemia       Date:  2012-10-22       Impact factor: 11.528

8.  The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.

Authors:  Mark T S Williams; Yasar M Yousafzai; Alex Elder; Klaus Rehe; Simon Bomken; Liron Frishman-Levy; Sigal Tavor; Paul Sinclair; Katie Dormon; Dino Masic; Tracey Perry; Victoria J Weston; Pamela Kearns; Helen Blair; Lisa J Russell; Olaf Heidenreich; Julie A E Irving; Shai Izraeli; Josef Vormoor; Gerard J Graham; Christina Halsey
Journal:  Blood       Date:  2016-02-11       Impact factor: 22.113

9.  Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.

Authors:  Juliana Benito; Yuexi Shi; Barbara Szymanska; Hernan Carol; Ingrid Boehm; Hongbo Lu; Sergej Konoplev; Wendy Fang; Patrick A Zweidler-McKay; Dario Campana; Gautam Borthakur; Carlos Bueso-Ramos; Elizabeth Shpall; Deborah A Thomas; Craig T Jordan; Hagop Kantarjian; William R Wilson; Richard Lock; Michael Andreeff; Marina Konopleva
Journal:  PLoS One       Date:  2011-08-11       Impact factor: 3.240

10.  Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis.

Authors:  Itaru Kato; Akira Niwa; Toshio Heike; Hisanori Fujino; Megumu K Saito; Katsutsugu Umeda; Hidefumi Hiramatsu; Mamoru Ito; Makiko Morita; Yoko Nishinaka; Souichi Adachi; Fumihiko Ishikawa; Tatsutoshi Nakahata
Journal:  PLoS One       Date:  2011-11-01       Impact factor: 3.240
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  8 in total

1.  When the bond breaks - targeting adhesion of leukemia cells to the meninges.

Authors:  Lennart Lenk; Fotini Vogiatzi; Denis M Schewe
Journal:  Haematologica       Date:  2020-08       Impact factor: 9.941

Review 2.  Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.

Authors:  Kjeld Schmiegelow; Christina Halsey; Maria Thastrup; Alasdair Duguid; Christian Mirian
Journal:  Leukemia       Date:  2022-10-20       Impact factor: 12.883

3.  Leukemia-derived exosomes and cytokines pave the way for entry into the brain.

Authors:  Ichiko Kinjyo; Denis Bragin; Rachel Grattan; Stuart S Winter; Bridget S Wilson
Journal:  J Leukoc Biol       Date:  2019-01-31       Impact factor: 4.962

4.  MicroRNA-181a as novel liquid biopsy marker of central nervous system involvement in pediatric acute lymphoblastic leukemia.

Authors:  Bálint Egyed; Nóra Kutszegi; Judit C Sági; András Gézsi; Andrea Rzepiel; Tamás Visnovitz; Péter Lőrincz; Judit Müller; Marianna Zombori; Csaba Szalai; Dániel J Erdélyi; Gábor T Kovács; Ágnes F Semsei
Journal:  J Transl Med       Date:  2020-06-22       Impact factor: 5.531

Review 5.  A narrative review of central nervous system involvement in acute leukemias.

Authors:  Dalma Deak; Nicolae Gorcea-Andronic; Valentina Sas; Patric Teodorescu; Catalin Constantinescu; Sabina Iluta; Sergiu Pasca; Ionut Hotea; Cristina Turcas; Vlad Moisoiu; Alina-Andreea Zimta; Simona Galdean; Jakob Steinheber; Ioana Rus; Sebastian Rauch; Cedric Richlitzki; Raluca Munteanu; Ancuta Jurj; Bobe Petrushev; Cristina Selicean; Mirela Marian; Olga Soritau; Alexandra Andries; Andrei Roman; Delia Dima; Alina Tanase; Olafur Sigurjonsson; Ciprian Tomuleasa
Journal:  Ann Transl Med       Date:  2021-01

6.  Co-Detection of VEGF-A and Its Regulator, microRNA-181a, May Indicate Central Nervous System Involvement in Pediatric Leukemia.

Authors:  Bálint Egyed; Anna Horváth; Ágnes F Semsei; Csaba Szalai; Judit Müller; Dániel J Erdélyi; Gábor T Kovács
Journal:  Pathol Oncol Res       Date:  2022-04-05       Impact factor: 2.874

7.  Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase.

Authors:  Angela Maria Savino; Sara Isabel Fernandes; Orianne Olivares; Anna Zemlyansky; Antony Cousins; Elke K Markert; Shani Barel; Ifat Geron; Liron Frishman; Yehudit Birger; Cornelia Eckert; Sergey Tumanov; Gillian MacKay; Jurre J Kamphorst; Pawel Herzyk; Jonatan Fernández-García; Ifat Abramovich; Inbal Mor; Michela Bardini; Ersilia Barin; Sudha Janaki-Raman; Justin R Cross; Michael G Kharas; Eyal Gottlieb; Shai Izraeli; Christina Halsey
Journal:  Nat Cancer       Date:  2020-09-28

Review 8.  Metabolic Reprogramming and Cell Adhesion in Acute Leukemia Adaptation to the CNS Niche.

Authors:  Nitesh D Sharma; Esra'a Keewan; Ksenia Matlawska-Wasowska
Journal:  Front Cell Dev Biol       Date:  2021-12-10
  8 in total

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