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Literature DB >> 28422952

When cancer needs what's non-essential.

Mark R Sullivan¹, Matthew G Vander Heiden^1,2.

Abstract

The non-essential amino acids serine and glycine are critical for proliferative metabolism. A study in Nature now finds that dietary serine and glycine deprivation inhibits growth of some tumours. Whether this dietary intervention is effective depends on both the oncogenic context and tumour tissue of origin.

Entities: Chemical Disease

Mesh：

Substances：
Serine
Glycine

Year: 2017 PMID： 28422952 DOI： 10.1038/ncb3523

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

1. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.

Authors: Mohit Jain; Roland Nilsson; Sonia Sharma; Nikhil Madhusudhan; Toshimori Kitami; Amanda L Souza; Ran Kafri; Marc W Kirschner; Clary B Clish; Vamsi K Mootha
Journal: Science Date: 2012-05-25 Impact factor: 47.728

2. Whole body autoradiographic study on the distribution of 14C-D-serine administered intravenously to rats.

Authors: K Imai; T Fukushima; T Santa; H Homma; Y Huang; M Shirao; K Miura
Journal: Amino Acids Date: 1998 Impact factor: 3.520

3. Proteomics. Tissue-based map of the human proteome.

Authors: Mathias Uhlén; Linn Fagerberg; Björn M Hallström; Cecilia Lindskog; Per Oksvold; Adil Mardinoglu; Åsa Sivertsson; Caroline Kampf; Evelina Sjöstedt; Anna Asplund; IngMarie Olsson; Karolina Edlund; Emma Lundberg; Sanjay Navani; Cristina Al-Khalili Szigyarto; Jacob Odeberg; Dijana Djureinovic; Jenny Ottosson Takanen; Sophia Hober; Tove Alm; Per-Henrik Edqvist; Holger Berling; Hanna Tegel; Jan Mulder; Johan Rockberg; Peter Nilsson; Jochen M Schwenk; Marica Hamsten; Kalle von Feilitzen; Mattias Forsberg; Lukas Persson; Fredric Johansson; Martin Zwahlen; Gunnar von Heijne; Jens Nielsen; Fredrik Pontén
Journal: Science Date: 2015-01-23 Impact factor: 47.728

4. Modulating the therapeutic response of tumours to dietary serine and glycine starvation.

Authors: Oliver D K Maddocks; Dimitris Athineos; Eric C Cheung; Pearl Lee; Tong Zhang; Niels J F van den Broek; Gillian M Mackay; Christiaan F Labuschagne; David Gay; Flore Kruiswijk; Julianna Blagih; David F Vincent; Kirsteen J Campbell; Fatih Ceteci; Owen J Sansom; Karen Blyth; Karen H Vousden
Journal: Nature Date: 2017-04-19 Impact factor: 49.962

5. Serine catabolism regulates mitochondrial redox control during hypoxia.

Authors: Jiangbin Ye; Jing Fan; Sriram Venneti; Ying-Wooi Wan; Bruce R Pawel; Ji Zhang; Lydia W S Finley; Chao Lu; Tullia Lindsten; Justin R Cross; Guoliang Qing; Zhandong Liu; M Celeste Simon; Joshua D Rabinowitz; Craig B Thompson
Journal: Cancer Discov Date: 2014-09-03 Impact factor: 39.397

6. Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.

Authors: Christiaan F Labuschagne; Niels J F van den Broek; Gillian M Mackay; Karen H Vousden; Oliver D K Maddocks
Journal: Cell Rep Date: 2014-05-10 Impact factor: 9.423

7. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Authors: Richard Possemato; Kevin M Marks; Yoav D Shaul; Michael E Pacold; Dohoon Kim; Kıvanç Birsoy; Shalini Sethumadhavan; Hin-Koon Woo; Hyun G Jang; Abhishek K Jha; Walter W Chen; Francesca G Barrett; Nicolas Stransky; Zhi-Yang Tsun; Glenn S Cowley; Jordi Barretina; Nada Y Kalaany; Peggy P Hsu; Kathleen Ottina; Albert M Chan; Bingbing Yuan; Levi A Garraway; David E Root; Mari Mino-Kenudson; Elena F Brachtel; Edward M Driggers; David M Sabatini
Journal: Nature Date: 2011-08-18 Impact factor: 49.962

Review 8. Exploiting the bad eating habits of Ras-driven cancers.

Authors: Eileen White
Journal: Genes Dev Date: 2013-10-01 Impact factor: 11.361

9. Calorie restriction and cancer prevention: a mechanistic perspective.

Authors: Stephen D Hursting; Sarah M Dunlap; Nikki A Ford; Marcie J Hursting; Laura M Lashinger
Journal: Cancer Metab Date: 2013-03-07

10. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Authors: Oliver D K Maddocks; Celia R Berkers; Susan M Mason; Liang Zheng; Karen Blyth; Eyal Gottlieb; Karen H Vousden
Journal: Nature Date: 2012-12-16 Impact factor: 49.962

6 in total

Review 1. The ins and outs of serine and glycine metabolism in cancer.

Authors: Shauni L Geeraerts; Elien Heylen; Kim De Keersmaecker; Kim R Kampen
Journal: Nat Metab Date: 2021-01-28

2. Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy.

Authors: Benedikt Warth; Philipp Raffeiner; Ana Granados; Tao Huan; Mingliang Fang; Erica M Forsberg; H Paul Benton; Laura Goetz; Caroline H Johnson; Gary Siuzdak
Journal: Cell Chem Biol Date: 2018-01-11 Impact factor: 8.116

3. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.

Authors: Bryan Ngo; Eugenie Kim; Victoria Osorio-Vasquez; Sophia Doll; Sophia Bustraan; Roger J Liang; Alba Luengo; Shawn M Davidson; Ahmed Ali; Gino B Ferraro; Grant M Fischer; Roozbeh Eskandari; Diane S Kang; Jing Ni; Ariana Plasger; Vinagolu K Rajasekhar; Edward R Kastenhuber; Sarah Bacha; Roshan K Sriram; Benjamin D Stein; Samuel F Bakhoum; Matija Snuderl; Paolo Cotzia; John H Healey; Nello Mainolfi; Vipin Suri; Adam Friedman; Mark Manfredi; David M Sabatini; Drew R Jones; Min Yu; Jean J Zhao; Rakesh K Jain; Kayvan R Keshari; Michael A Davies; Matthew G Vander Heiden; Eva Hernando; Matthias Mann; Lewis C Cantley; Michael E Pacold
Journal: Cancer Discov Date: 2020-06-22 Impact factor: 39.397