Literature DB >> 2842274

Epstein-Barr virus nuclear antigens 1 and 2 in Burkitt lymphoma cell lines containing either 'A'- or 'B'-type virus.

T B Sculley1, D G Sculley, J H Pope, G W Bornkamm, G M Lenoir, A B Rickinson.   

Abstract

Epstein-Barr virus (EBV) has previously been classified into two different types according to the organization of the EB nuclear antigen 2 (EBNA2) gene region. Type A virus hybridizes with probes from B95-8 or M-ABA viruses and the B type virus with probes from the Jijoye virus strain. The substituted region in EBV type B codes for a different, but related EBNA2 antigen, named EBNA2B as opposed to EBNA2A. In this study Burkitt lymphoma cell lines, previously typed according to the EBV viral genomes they carry, as well as some matching lymphoblastoid cell lines were examined by immunoblotting for the expression of both EBNA1 and EBNA2 antigens. Variation in the molecular weight of EBNA1 indicated that both A and B virus types contained a variety of different virus isolates. EBNA2A was identified in all lines carrying A type viral genomes, but was not observed in any of the lines harboring B type virus. EBNA2B was identified in 4 of 10 Burkitt lymphoma lines carrying EBV type B.

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Year:  1988        PMID： 2842274     DOI： 10.1159/000150032

Source DB:  PubMed          Journal:  Intervirology        ISSN： 0300-5526            Impact factor:   1.763


  6 in total

1.  A simple and rapid technique to process formalin-fixed, paraffin-embedded tissues for the detection of viruses by the polymerase chain reaction.

Authors:  P Kiene; K Milde-Langosch; M Runkel; K Schulz; T Löning
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

2.  Evolutionary dynamics of genetic variation in Epstein-Barr virus isolates of diverse geographical origins: evidence for immune pressure-independent genetic drift.

Authors:  R Khanna; R W Slade; L Poulsen; D J Moss; S R Burrows; J Nicholls; J M Burrows
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

3.  Nonresponsiveness to an immunodominant Epstein-Barr virus-encoded cytotoxic T-lymphocyte epitope in nuclear antigen 3A: implications for vaccine strategies.

Authors:  C Schmidt; S R Burrows; T B Sculley; D J Moss; I S Misko
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

4.  Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes.

Authors:  J Sample; L Young; B Martin; T Chatman; E Kieff; A Rickinson; E Kieff
Journal:  J Virol       Date:  1990-09       Impact factor: 5.103

5.  Failure of Epstein-Barr virus-specific cytotoxic T lymphocytes to lyse B cells transformed with the B95-8 strain is mapped to an epitope that associates with the HLA-B8 antigen.

Authors:  I S Misko; C Schmidt; M Honeyman; T D Soszynski; T B Sculley; S R Burrows; D J Moss; K Burman
Journal:  Clin Exp Immunol       Date:  1992-01       Impact factor: 4.330

6.  Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs.

Authors:  Susanne Delecluse; Jiyang Yu; Katharina Bernhardt; Janina Haar; Remy Poirey; Ming-Han Tsai; Rama Kiblawi; Annette Kopp-Schneider; Paul Schnitzler; Martin Zeier; Peter Dreger; Patrick Wuchter; Olcay Cem Bulut; Uta Behrends; Henri-Jacques Delecluse
Journal:  PLoS One       Date:  2019-09-30       Impact factor: 3.240
  6 in total

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