Literature DB >> 28421449

Flow cytometric analysis of the ERCC1, marker of DNA damage repair, in the tumor specimens embedded into paraffin blocks.

T A Bogush1, E A Dudko2, A N Grishanina2, V T Zarkua2, E A Bogush2, A A Basharina3, B E Polotsky2, S A Tjulandin2, M M Davydov2, M I Davydov2.   

Abstract

The differences in expression of ERCC1 were estimated between tumor specimens embedded into paraffin blocks and surgical biopsy specimens of non-small cell lung cancer as well as breast and ovarian cancers. Concordance or differences not higher than 20% were observed in 73% of the cases. The number of the cases with more significant differences in ERCC1 expression was less than 17%. The results show that ERCC1 detection in surgical biopsy specimens by flow cytometry is the more preferable method due to reduced preanalytical phase of the analysis.

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Year:  2017        PMID: 28421449     DOI: 10.1134/S1607672917010033

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN: 1607-6729            Impact factor:   0.788


  3 in total

1.  Analysis of informativeness of immunohistochemical and flow cytometric methods for estrogen receptor α assessment.

Authors:  T A Bogush; E A Dudko; M V Rodionova; E A Bogush; V J Kirsanov; V V Rodionov; I K Vorotnikov
Journal:  Dokl Biochem Biophys       Date:  2016-01-05       Impact factor: 0.788

Review 2.  Sensitivity and resistance to treatment in the primary management of epithelial ovarian cancer.

Authors:  Pierre-Emmanuel Colombo; Michel Fabbro; Charles Theillet; Frédéric Bibeau; Philippe Rouanet; Isabelle Ray-Coquard
Journal:  Crit Rev Oncol Hematol       Date:  2013-09-08       Impact factor: 6.312

3.  Intratumour variation of biomarker expression by immunohistochemistry in resectable non-small cell lung cancer.

Authors:  Jan Nyrop Jakobsen; Eric Santoni-Rugiu; Jesper Ravn; Jens Benn Sørensen
Journal:  Eur J Cancer       Date:  2013-04-29       Impact factor: 9.162

  3 in total
  1 in total

1.  Estrogen Receptors alpha and beta in Ovarian Cancer: Expression Level and Prognosis.

Authors:  T A Bogush; A A Basharina; E A Bogush; O M Ryabinina; A S Tjulandina; S A Tjulandin
Journal:  Dokl Biochem Biophys       Date:  2018-11-05       Impact factor: 0.788

  1 in total

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