Pierre Bel Lassen1,2,3,4, Frederic Charlotte5, Yuejun Liu1,2,3,4, Pierre Bedossa6,7, Gilles Le Naour5, Joan Tordjman1,2,3, Christine Poitou1,2,3,4, Jean-Luc Bouillot8, Laurent Genser1,2,3,9, Jean-Daniel Zucker1,2,3,10, Nataliya Sokolovska1,2,3, Judith Aron-Wisnewsky1,2,3,4, Karine Clément1,2,3,4. 1. Institute of Cardiometabolism and Nutrition (ICAN) F-75013 Paris France. 2. INSERM, UMRS 1166, Nutriomic Team 6, F-75013 Paris, France. 3. Sorbonne Universités, UPMC Université Paris 06, UMRS1166, F-75005 Paris France. 4. Nutrition Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), F-75013 Paris, France. 5. Department of Pathology, Pitié-Salpêtrière Hospital, AP-HP, UIMAP, UPMC Université Paris 06, F-75013 Paris, France. 6. Beaujon Hospital, Pathology Department, AP-HP, F-92110 Clichy, France. 7. Centre de Recherche Bichat-Beaujon, INSERM U773, University Paris-Diderot, F-75018 Paris, France. 8. Department of General, Digestive, and Metabolic Surgery, Ambroise Paré University Hospital, AP-HP, Versailles Saint-Quentin University, F-92100 Boulogne, France. 9. Department of Digestive and Hepato-Pancreato-Biliary Surgery, Liver Transplantation, Pitié-Salpêtrière Hospital, AP-HP, F-75013 Paris, France. 10. Sorbonne Universités, IRD, UMI 209, UMMISCO, IRD France Nord, F-93143 Bondy, France.
Abstract
Context: Bariatric surgery (BS) induces major and sustainable weight loss in many patients. Factors predicting poor weight-loss response (PR) need to be identified to improve patient care. Quantification of subcutaneous adipose tissue (scAT) fibrosis is negatively associated with post-BS weight loss, but whether it could constitute a predictor applicable in clinical routine remains to be demonstrated. Objective: To create a semiquantitative score evaluating scAT fibrosis and test its predictive value on weight-loss response after Roux-en-Y gastric bypass (RYGB). Methods: We created a fibrosis score of adipose tissue (FAT score) integrating perilobular and pericellular fibrosis. Using this score, we characterized 183 perioperative scAT biopsy specimens from severely obese patients who underwent RYGB (n = 85 from a training cohort; n = 98 from a confirmation cohort). PR to RYGB was defined as <28% of total weight loss at 1 year (lowest tertile). The link between FAT score and PR was tested in univariate and multivariate models. Results: FAT score was directly associated with increasing scAT fibrosis measured by a standard quantification method (P for trend <0.001). FAT score interobserver agreement was good (κ = 0.76). FAT score ≥2 was significantly associated with PR. The association remained significant after adjustment for age, diabetes status, hypertension, percent fat mass, and interleukin-6 level (adjusted odds ratio, 3.6; 95% confidence interval, 1.8 to 7.2; P = 0.003). Conclusion: The FAT score is a new, simple, semiquantitative evaluation of human scAT fibrosis that may help identify patients with a potential limited weight-loss response to RYGB.
Context: Bariatric surgery (BS) induces major and sustainable weight loss in many patients. Factors predicting poor weight-loss response (PR) need to be identified to improve patient care. Quantification of subcutaneous adipose tissue (scAT) fibrosis is negatively associated with post-BS weight loss, but whether it could constitute a predictor applicable in clinical routine remains to be demonstrated. Objective: To create a semiquantitative score evaluating scAT fibrosis and test its predictive value on weight-loss response after Roux-en-Y gastric bypass (RYGB). Methods: We created a fibrosis score of adipose tissue (FAT score) integrating perilobular and pericellular fibrosis. Using this score, we characterized 183 perioperative scAT biopsy specimens from severely obesepatients who underwent RYGB (n = 85 from a training cohort; n = 98 from a confirmation cohort). PR to RYGB was defined as <28% of total weight loss at 1 year (lowest tertile). The link between FAT score and PR was tested in univariate and multivariate models. Results: FAT score was directly associated with increasing scAT fibrosis measured by a standard quantification method (P for trend <0.001). FAT score interobserver agreement was good (κ = 0.76). FAT score ≥2 was significantly associated with PR. The association remained significant after adjustment for age, diabetes status, hypertension, percent fat mass, and interleukin-6 level (adjusted odds ratio, 3.6; 95% confidence interval, 1.8 to 7.2; P = 0.003). Conclusion: The FAT score is a new, simple, semiquantitative evaluation of human scAT fibrosis that may help identify patients with a potential limited weight-loss response to RYGB.
Authors: M Svendstrup; K H Allin; T I A Sørensen; T H Hansen; N Grarup; T Hansen; H Vestergaard Journal: Int J Obes (Lond) Date: 2017-11-16 Impact factor: 5.095
Authors: V Pellegrinelli; S Rodriguez-Cuenca; C Rouault; E Figueroa-Juarez; H Schilbert; S Virtue; J M Moreno-Navarrete; G Bidault; M C Vázquez-Borrego; A R Dias; B Pucker; M Dale; M Campbell; S Carobbio; Y H Lin; M Vacca; J Aron-Wisnewsky; S Mora; M M Masiero; A Emmanouilidou; S Mukhopadhyay; G Dougan; M den Hoed; R J F Loos; J M Fernández-Real; D Chiarugi; K Clément; A Vidal-Puig Journal: Nat Metab Date: 2022-04-25
Authors: David Lopez-Perez; Anaïs Redruello-Romero; Jesús Garcia-Rubio; Carlos Arana; Luis A Garcia-Escudero; Francisco Tamayo; Jose D Puentes-Pardo; Sara Moreno-SanJuan; Javier Salmeron; Armando Blanco; Julio Galvez; Josefa Leon; Ángel Carazo Journal: Front Immunol Date: 2021-05-21 Impact factor: 7.561