Literature DB >> 28417231

High Cholesterol/Low Cholesterol: Effects in Biological Membranes: A Review.

Witold K Subczynski1, Marta Pasenkiewicz-Gierula2, Justyna Widomska3, Laxman Mainali4, Marija Raguz4,5.   

Abstract

Lipid composition determines membrane properties, and cholesterol plays a major role in this determination as it regulates membrane fluidity and permeability, as well as induces the formation of coexisting phases and domains in the membrane. Biological membranes display a very diverse lipid composition, the lateral organization of which plays a crucial role in regulating a variety of membrane functions. We hypothesize that, during biological evolution, membranes with a particular cholesterol content were selected to perform certain functions in the cells of eukaryotic organisms. In this review, we discuss the major membrane properties induced by cholesterol, and their relationship to certain membrane functions.

Entities:  

Keywords:  Cholesterol; EPR; Lipid spin label; Membrane domains; Oximetry

Mesh：

Substances：

Year:  2017        PMID： 28417231      PMCID： PMC5645210          DOI： 10.1007/s12013-017-0792-7

Source DB:  PubMed          Journal:  Cell Biochem Biophys        ISSN： 1085-9195            Impact factor:   2.194


  93 in total

1.  The immiscible cholesterol bilayer domain exists as an integral part of phospholipid bilayer membranes.

Authors:  Marija Raguz; Laxman Mainali; Justyna Widomska; Witold K Subczynski
Journal:  Biochim Biophys Acta       Date:  2010-12-28

2.  Using spin-label electron paramagnetic resonance (EPR) to discriminate and characterize the cholesterol bilayer domain.

Authors:  Marija Raguz; Laxman Mainali; Justyna Widomska; Witold K Subczynski
Journal:  Chem Phys Lipids       Date:  2011-08-09       Impact factor: 3.329

3.  Effects of phospholipid unsaturation on the membrane/water interface: a molecular simulation study.

Authors:  K Murzyn; T Róg; G Jezierski; Y Takaoka; M Pasenkiewicz-Gierula
Journal:  Biophys J       Date:  2001-07       Impact factor: 4.033

4.  Properties of membranes derived from the total lipids extracted from clear and cataractous lenses of 61-70-year-old human donors.

Authors:  Laxman Mainali; Marija Raguz; William J O'Brien; Witold K Subczynski
Journal:  Eur Biophys J       Date:  2014-12-14       Impact factor: 1.733

5.  Oxygen transport parameter in membranes as deduced by saturation recovery measurements of spin-lattice relaxation times of spin labels.

Authors:  A Kusumi; W K Subczynski; J S Hyde
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

6.  Studying lipid organization in biological membranes using liposomes and EPR spin labeling.

Authors:  Witold K Subczynski; Marija Raguz; Justyna Widomska
Journal:  Methods Mol Biol       Date:  2010

7.  Molecular organization and dynamics in bacteriorhodopsin-rich reconstituted membranes: discrimination of lipid environments by the oxygen transport parameter using a pulse ESR spin-labeling technique.

Authors:  I Ashikawa; J J Yin; W K Subczynski; T Kouyama; J S Hyde; A Kusumi
Journal:  Biochemistry       Date:  1994-04-26       Impact factor: 3.162

8.  Physical properties of the lipid bilayer membrane made of cortical and nuclear bovine lens lipids: EPR spin-labeling studies.

Authors:  Marija Raguz; Justyna Widomska; James Dillon; Elizabeth R Gaillard; Witold K Subczynski
Journal:  Biochim Biophys Acta       Date:  2009-09-15

Review 9.  Ion selectivity in channels and transporters.

Authors:  Benoît Roux; Simon Bernèche; Bernhard Egwolf; Bogdan Lev; Sergei Y Noskov; Christopher N Rowley; Haibo Yu
Journal:  J Gen Physiol       Date:  2011-05       Impact factor: 4.086

10.  Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life.

Authors:  Niels Lynnerup; Henrik Kjeldsen; Steffen Heegaard; Christina Jacobsen; Jan Heinemeier
Journal:  PLoS One       Date:  2008-01-30       Impact factor: 3.240
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  54 in total

Review 1.  Of membranes and malaria: phospholipid asymmetry in Plasmodium falciparum-infected red blood cells.

Authors:  Merryn Fraser; Kai Matuschewski; Alexander G Maier
Journal:  Cell Mol Life Sci       Date:  2021-03-13       Impact factor: 9.261

2.  Bilayer Thickness and Curvature Influence Binding and Insertion of a pHLIP Peptide.

Authors:  Alexander G Karabadzhak; Dhammika Weerakkody; John Deacon; Oleg A Andreev; Yana K Reshetnyak; Donald M Engelman
Journal:  Biophys J       Date:  2018-05-08       Impact factor: 4.033

3.  Electron donor cytochrome b5 is required for hyphal tip accumulation of sterol-rich plasma membrane domains and membrane fluidity in Aspergillus fumigatus.

Authors:  Chi Zhang; Yiran Ren; Lu Gao; Huiyu Gu; Ling Lu
Journal:  Appl Environ Microbiol       Date:  2020-11-30       Impact factor: 4.792

Review 4.  The interaction of steroids with phospholipid bilayers and membranes.

Authors:  Jackson Crowley; Minduli Withana; Evelyne Deplazes
Journal:  Biophys Rev       Date:  2021-12-02

5.  Membrane fluidity, composition, and charge affect the activity and selectivity of the AMP ascaphin-8.

Authors:  Adriana Morales-Martínez; Brandt Bertrand; Juan M Hernández-Meza; Ramón Garduño-Juárez; Jesús Silva-Sanchez; Carlos Munoz-Garay
Journal:  Biophys J       Date:  2022-07-16       Impact factor: 3.699

6.  Cholesterol and cholesterol bilayer domains inhibit binding of alpha-crystallin to the membranes made of the major phospholipids of eye lens fiber cell plasma membranes.

Authors:  Raju Timsina; Geraline Trossi-Torres; Matthew O'Dell; Nawal K Khadka; Laxman Mainali
Journal:  Exp Eye Res       Date:  2021-03-17       Impact factor: 3.467

7.  Differences in the properties of porcine cortical and nuclear fiber cell plasma membranes revealed by saturation recovery EPR spin labeling measurements.

Authors:  Natalia Stein; Witold K Subczynski
Journal:  Exp Eye Res       Date:  2021-03-12       Impact factor: 3.467

Review 8.  Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine.

Authors:  Faustino Mollinedo; Consuelo Gajate
Journal:  Pharmaceutics       Date:  2021-05-20       Impact factor: 6.321

9.  CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells.

Authors:  Anna L L Matos; Fabian Keller; Tristan Wegner; Carla Elizabeth Cadena Del Castillo; David Grill; Sergej Kudruk; Anne Spang; Frank Glorius; Andreas Heuer; Volker Gerke
Journal:  Commun Biol       Date:  2021-06-11

10.  Dexamethasone-Loaded Nanostructured Lipid Carriers for the Treatment of Dry Eye Disease.

Authors:  Sangeeta Kumari; Madhuri Dandamudi; Sweta Rani; Elke Behaeghel; Gautam Behl; David Kent; Niall J O'Reilly; Orla O'Donovan; Peter McLoughlin; Laurence Fitzhenry
Journal:  Pharmaceutics       Date:  2021-06-18       Impact factor: 6.321
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