Literature DB >> 28417162

S100A6 protein: functional roles.

Rosario Donato1,2, Guglielmo Sorci3,4, Ileana Giambanco3.   

Abstract

S100A6 protein belongs to the A group of the S100 protein family of Ca2+-binding proteins. It is expressed in a limited number of cell types in adult normal tissues and in several tumor cell types. As an intracellular protein, S100A6 has been implicated in the regulation of several cellular functions, such as proliferation, apoptosis, the cytoskeleton dynamics, and the cellular response to different stress factors. S100A6 can be secreted/released by certain cell types which points to extracellular effects of the protein. RAGE (receptor for advanced glycation endproducts) and integrin β1 transduce some extracellular S100A6's effects. Dosage of serum S100A6 might aid in diagnosis in oncology.

Entities:  

Keywords:  Cancer; Cytoskeleton; Invasion; Migration/motility; Proliferation; Receptor; S100A6 protein

Mesh：

Substances：

Year:  2017        PMID： 28417162     DOI： 10.1007/s00018-017-2526-9

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  150 in total

1.  Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition.

Authors:  Young-Tae Lee; Yoana N Dimitrova; Gabriela Schneider; Whitney B Ridenour; Shibani Bhattacharya; Sarah E Soss; Richard M Caprioli; Anna Filipek; Walter J Chazin
Journal:  Biochemistry       Date:  2008-09-20       Impact factor: 3.162

2.  Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function.

Authors:  Anna K Busch; Damien Cordery; Gareth S Denyer; Trevor J Biden
Journal:  Diabetes       Date:  2002-04       Impact factor: 9.461

3.  S100A6 is a negative regulator of the induction of cardiac genes by trophic stimuli in cultured rat myocytes.

Authors:  J N Tsoporis; A Marks; A Haddad; D O'Hanlon; S Jolly; T G Parker
Journal:  Exp Cell Res       Date:  2004-11-13       Impact factor: 3.905

4.  S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes.

Authors:  Taku Saito; Toshiyuki Ikeda; Kozo Nakamura; Ung-il Chung; Hiroshi Kawaguchi
Journal:  EMBO Rep       Date:  2007-03-30       Impact factor: 8.807

5.  The Calcium-Binding Protein S100A6 Accelerates Human Osteosarcoma Growth by Promoting Cell Proliferation and Inhibiting Osteogenic Differentiation.

Authors:  Yasha Li; Eric R Wagner; Zhengjian Yan; Zhonliang Wang; Gaurav Luther; Wei Jiang; Jixing Ye; Qiang Wei; Jing Wang; Lianggong Zhao; Shun Lu; Xin Wang; Maryam K Mohammed; Shengli Tang; Hao Liu; Jiaming Fan; Fugui Zhang; Yulong Zou; Dongzhe Song; Junyi Liao; Rex C Haydon; Hue H Luu; Tong-Chuan He
Journal:  Cell Physiol Biochem       Date:  2015-12-09

6.  Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma.

Authors:  Q Yang; D O'Hanlon; C W Heizmann; A Marks
Journal:  Exp Cell Res       Date:  1999-02-01       Impact factor: 3.905

7.  S100A6 as a potential serum prognostic biomarker and therapeutic target in gastric cancer.

Authors:  Jianli Zhang; Kejun Zhang; Xiuli Jiang; Jian Zhang
Journal:  Dig Dis Sci       Date:  2014-04-05       Impact factor: 3.199

8.  S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling.

Authors:  Carolin Lerchenmüller; Julian Heißenberg; Federico Damilano; Vassilios J Bezzeridis; Isabel Krämer; Marie-Luce Bochaton-Piallat; Kristóf Hirschberg; Martin Busch; Hugo A Katus; Karsten Peppel; Anthony Rosenzweig; Hauke Busch; Melanie Boerries; Patrick Most
Journal:  Arterioscler Thromb Vasc Biol       Date:  2016-07-07       Impact factor: 8.311

9.  Proteins with altered levels in plasma from glioblastoma patients as revealed by iTRAQ-based quantitative proteomic analysis.

Authors:  Poonam Gautam; Sudha C Nair; Manoj Kumar Gupta; Rakesh Sharma; Ravindra Varma Polisetty; Megha S Uppin; Challa Sundaram; Aneel K Puligopu; Praveen Ankathi; Aniruddh K Purohit; Giriraj R Chandak; H C Harsha; Ravi Sirdeshmukh
Journal:  PLoS One       Date:  2012-09-28       Impact factor: 3.240

10.  Quantitative Proteomics Analysis of Tissue Interstitial Fluid for Identification of Novel Serum Candidate Diagnostic Marker for Hepatocellular Carcinoma.

Authors:  Wei Sun; Baocai Xing; Lihai Guo; Zhilei Liu; Jinsong Mu; Longqin Sun; Handong Wei; Xiaohang Zhao; Xiaohong Qian; Ying Jiang; Fuchu He
Journal:  Sci Rep       Date:  2016-05-24       Impact factor: 4.379
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  47 in total

Review 1.  Multifarious diagnostic possibilities of the S100 protein family: predominantly in pediatrics and neonatology.

Authors:  Anna Medkova; Josef Srovnal; Jarmila Potomkova; Jana Volejnikova; Vladimir Mihal
Journal:  World J Pediatr       Date:  2018-06-01       Impact factor: 2.764

2.  S100A6/miR193a regulates the proliferation, invasion, migration and angiogenesis of lung cancer cells through the P53 acetylation.

Authors:  Peng Li; Xiaodong Lv; Zhiqiang Zhang; Shanshan Xie
Journal:  Am J Transl Res       Date:  2019-08-15       Impact factor: 4.060

3.  EZB-ICR Cell Line: A New Established and Characterized Oral Squamous Cell Carcinoma Cell Line From Tongue.

Authors:  Nooshafarin Chenari; Bijan Khademi; Mahboobeh Razmkhah
Journal:  Asian Pac J Cancer Prev       Date:  2021-01-01

4.  Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration.

Authors:  Daigo Tsubokawa; Taisei Kikuchi; Jae Man Lee; Takahiro Kusakabe; Yasuhiko Yamamoto; Haruhiko Maruyama
Journal:  PLoS Pathog       Date:  2021-06-03       Impact factor: 6.823

5.  Quantitative Proteomics Reveal an Altered Pattern of Protein Expression in Brain Tissue from Mice Lacking GPR37 and GPR37L1.

Authors:  TrangKimberly Thu Nguyen; Eric B Dammer; Sharon A Owino; Michelle M Giddens; Nora S Madaras; Duc M Duong; Nicholas T Seyfried; Randy A Hall
Journal:  J Proteome Res       Date:  2020-02-07       Impact factor: 4.466

6.  Transcriptomes of an Array of Chicken Ovary, Intestinal, and Immune Cells and Tissues.

Authors:  Eliah G Overbey; Theros T Ng; Pietro Catini; Lisa M Griggs; Paul Stewart; Suzana Tkalcic; R David Hawkins; Yvonne Drechsler
Journal:  Front Genet       Date:  2021-06-30       Impact factor: 4.599

7.  Antifungal activity of dendritic cell lysosomal proteins against Cryptococcus neoformans.

Authors:  Benjamin N Nelson; Savannah G Beakley; Sierra Posey; Brittney Conn; Emma Maritz; Janakiram Seshu; Karen L Wozniak
Journal:  Sci Rep       Date:  2021-06-30       Impact factor: 4.379

8.  Myeloid cell interferon responses correlate with clearance of SARS-CoV-2.

Authors:  Dhiraj Singh; Ekaterina Aladyeva; Shibali Das; Bindu Singh; Ekaterina Esaulova; Amanda Swain; Mushtaq Ahmed; Journey Cole; Chivonne Moodley; Smriti Mehra; Larry Schlesinger; Maxim Artyomov; Shabaana Khader; Deepak Kaushal
Journal:  Res Sq       Date:  2021-07-15

9.  S100A gene family: immune-related prognostic biomarkers and therapeutic targets for low-grade glioma.

Authors:  Yu Zhang; Xin Yang; Xiao-Lin Zhu; Hao Bai; Zhuang-Zhuang Wang; Jun-Jie Zhang; Chun-Yan Hao; Hu-Bin Duan
Journal:  Aging (Albany NY)       Date:  2021-06-08       Impact factor: 5.682

Review 10.  The S100 Protein Family as Players and Therapeutic Targets in Pulmonary Diseases.

Authors:  Zeeshan Sattar; Alnardo Lora; Bakr Jundi; Christopher Railwah; Patrick Geraghty
Journal:  Pulm Med       Date:  2021-06-18
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