Literature DB >> 2841432

Quantitative local cerebral blood flow measurements with technetium-99m HM-PAO: evaluation using multiple radionuclide digital quantitative autoradiography.

J L Lear1.   

Abstract

We investigated d,1 [99mTc]hexamethylpropyleneamine oxime complex (HM-PAO) as a tracer for quantitative measurement of local cerebral blood flow (LCBF) in a series of awake male rats. LCBF measurements with HM-PAO were compared to those of two other tracers, [14C] iodoantipyrine (IAP) and [201Tl]diethyldithiocarbamate (DDC), using quantitative double and triple tracer digital autoradiography. LCBF values with HM-PAO averaged 64% those of IAP and were generally linearly related. Detailed analysis suggested that the underestimation of LCBF by HM-PAO was related to blood constituent binding and/or rapid conversion to a noncerebrophilic compound, as well as noninstantaneous cerebral trapping, rather than to diffusion limitation.

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Year:  1988        PMID： 2841432

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  10 in total

1.  Regional changes in forebrain activation during the early and late phase of formalin nociception: analysis using cerebral blood flow in the rat.

Authors:  T J Morrow; P E Paulson; P J Danneman; K L Casey
Journal:  Pain       Date:  1998-04       Impact factor: 6.961

2.  In vivo metabolism and kinetics of 99mTc-HMPAO.

Authors:  G Lucignani; C Rossetti; P Ferrario; L Zecca; M C Gilardi; F Zito; D Perani; G L Lenzi; F Fazio
Journal:  Eur J Nucl Med       Date:  1990

3.  Does the washout phenomenon of Tc-99m HM-PAO correlate to the "filling-in" phenomenon of I-123 IMP with brain SPECT?

Authors:  K Hayashida; T Nishimura; S Imakita; T Uehara
Journal:  Neuroradiology       Date:  1990       Impact factor: 2.804

4.  Ultra-high spatial resolution basal and evoked cerebral blood flow MRI of the rat brain.

Authors:  Qiang Shen; Shiliang Huang; Timothy Q Duong
Journal:  Brain Res       Date:  2014-12-31       Impact factor: 3.252

5.  HM-PAO-imaging and herpes encephalitis.

Authors:  G M Cleator; A G Lewis; P E Klapper; H L Sharma; A M Smith
Journal:  Arch Virol       Date:  1989       Impact factor: 2.574

6.  Evaluation of cerebral vasospasm in patients with subarachnoid hemorrhage using single photon emission computed tomography.

Authors:  S Naderi; M A Ozgüven; H Bayhan; H Gökalp; A Erdoğan; N Egemen
Journal:  Neurosurg Rev       Date:  1994       Impact factor: 3.042

7.  Increased rCBF in gray matter heterotopias detected by SPECT using 99mTc hexamethyl-propylenamine oxime.

Authors:  H Henkes; N Hosten; M Cordes; K Neumann; M L Hansen
Journal:  Neuroradiology       Date:  1991       Impact factor: 2.804

8.  Single photon emission computed tomography in patients with acute hydrocephalus or with cerebral ischaemia after subarachnoid haemorrhage.

Authors:  D Hasan; J van Peski; I Loeve; E P Krenning; M Vermeulen
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-06       Impact factor: 10.154

9.  Assessment of cerebral perfusion with single-photon emission tomography in normal subjects and in patients with Alzheimer's disease: effects of region of interest selection.

Authors:  J J Claus; F van Harskamp; M M Breteler; E P Krenning; T J van der Cammen; A Hofman; D Hasan
Journal:  Eur J Nucl Med       Date:  1994-10

10.  Quantitative single-photon emission tomography for tumour blood flow measurement in bronchial carcinoma.

Authors:  N P Rowell; M A Flower; B Cronin; V R McCready
Journal:  Eur J Nucl Med       Date:  1993-07
  10 in total

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