Literature DB >> 28413636

Nuclear magnetic resonance metabolomics and human liver diseases: The principles and evidence associated with protein and carbohydrate metabolism.

Laurence Le Moyec1, Mohamed N Triba2, Pierre Nahon3,4,5, Nadia Bouchemal2, Edith Hantz2, Corentine Goossens2, Roland Amathieu2,6, Philippe Savarin2.   

Abstract

During the last decade, metabolomics has become widely used in the field of human diseases. Numerous studies have demonstrated that this is a powerful technique for improving the understanding, diagnosis and management of various types of liver disease, such as acute and chronic liver diseases, and liver transplantation. Nuclear magnetic resonance (NMR) spectroscopy is one of the two most commonly applied methods for metabolomics. The aim of the present review was to investigate the results from recent key publications focusing on aspects of protein and carbohydrate metabolism. The review includes existing procedures, which are currently used for NMR data acquisition and statistical analysis. In addition, notable results obtained by these studies on protein and carbohydrate metabolism concerning human liver diseases are presented.

Entities:  

Keywords:  chronic and acute liver disease; metabolomics; nuclear magnetic resonance

Year:  2017        PMID： 28413636      PMCID： PMC5374905          DOI： 10.3892/br.2017.868

Source DB:  PubMed          Journal:  Biomed Rep        ISSN： 2049-9434


  38 in total

1.  Urinary metabolic biomarkers of hepatocellular carcinoma in an Egyptian population: a validation study.

Authors:  Mohamed I F Shariff; Asmaa I Gomaa; I Jane Cox; Madhvi Patel; Horace R T Williams; Mary M E Crossey; Andrew V Thillainayagam; Howard C Thomas; Imam Waked; Shahid A Khan; Simon D Taylor-Robinson
Journal:  J Proteome Res       Date:  2011-03-09       Impact factor: 4.466

2.  Non-linear modeling of 1H NMR metabonomic data using kernel-based orthogonal projections to latent structures optimized by simulated annealing.

Authors:  Judith M Fonville; Max Bylesjö; Muireann Coen; Jeremy K Nicholson; Elaine Holmes; John C Lindon; Mattias Rantalainen
Journal:  Anal Chim Acta       Date:  2011-04-20       Impact factor: 6.558

3.  Metabolic assessment of human liver transplants from biopsy samples at the donor and recipient stages using high-resolution magic angle spinning 1H NMR spectroscopy.

Authors:  Iola F Duarte; Elizabeth G Stanley; Elaine Holmes; John C Lindon; Ana M Gil; Huiru Tang; Roxanne Ferdinand; Claire Gavaghan McKee; Jeremy K Nicholson; Hector Vilca-Melendez; Nigel Heaton; Gerard M Murphy
Journal:  Anal Chem       Date:  2005-09-01       Impact factor: 6.986

4.  Prognostic significance of a combination of pre- and post-treatment tumor markers for hepatocellular carcinoma curatively treated with hepatectomy.

Authors:  Hidenori Toyoda; Takashi Kumada; Toshifumi Tada; Takuro Niinomi; Takanori Ito; Yuji Kaneoka; Atsuyuki Maeda
Journal:  J Hepatol       Date:  2012-07-20       Impact factor: 25.083

5.  Early detection of graft failure using the blood metabolic profile of a liver recipient.

Authors:  Natalie J Serkova; Yu Zhang; John L Coatney; Lawrence Hunter; Michael E Wachs; Claus U Niemann; M Susan Mandell
Journal:  Transplantation       Date:  2007-02-27       Impact factor: 4.939

6.  Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance.

Authors:  Beatriz Jiménez; Carmina Montoliu; David A MacIntyre; Miguel A Serra; Abdallah Wassel; María Jover; Manuel Romero-Gomez; Jose M Rodrigo; Antonio Pineda-Lucena; Vicente Felipo
Journal:  J Proteome Res       Date:  2010-10-01       Impact factor: 4.466

7.  A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran.

Authors:  Ulf Andersson; Johan Lindberg; Shunghuang Wang; Raji Balasubramanian; Maritha Marcusson-Ståhl; Mira Hannula; Chenhui Zeng; Peter J Juhasz; Johan Kolmert; Jonas Bäckström; Lars Nord; Kerstin Nilsson; Steve Martin; Björn Glinghammar; Karin Cederbrant; Ina Schuppe-Koistinen
Journal:  Biomarkers       Date:  2009-12       Impact factor: 2.658

8.  Metabonomic studies of human hepatocellular carcinoma using high-resolution magic-angle spinning 1H NMR spectroscopy in conjunction with multivariate data analysis.

Authors:  Yongxia Yang; Chenglong Li; Xiu Nie; Xiansong Feng; Wenxue Chen; Yong Yue; Huiru Tang; Feng Deng
Journal:  J Proteome Res       Date:  2007-06-12       Impact factor: 4.466

9.  Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease.

Authors:  Sulin Cheng; Petri Wiklund; Reija Autio; Ronald Borra; Xiaowei Ojanen; Leiting Xu; Timo Törmäkangas; Markku Alen
Journal:  PLoS One       Date:  2015-10-06       Impact factor: 3.240

10.  Metabolic Characterization of Advanced Liver Fibrosis in HCV Patients as Studied by Serum 1H-NMR Spectroscopy.

Authors:  Nieves Embade; Zoe Mariño; Tammo Diercks; Ainara Cano; Sabela Lens; Diana Cabrera; Miquel Navasa; Juan M Falcón-Pérez; Joan Caballería; Azucena Castro; Jaume Bosch; José M Mato; Oscar Millet
Journal:  PLoS One       Date:  2016-05-09       Impact factor: 3.240
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  4 in total

Review 1.  Current body composition measurement techniques.

Authors:  Thaisa Lemos; Dympna Gallagher
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2017-10       Impact factor: 3.243

2.  Proton NMR Enables the Absolute Quantification of Aqueous Metabolites and Lipid Classes in Unique Mouse Liver Samples.

Authors:  Aurélien Amiel; Marie Tremblay-Franco; Roselyne Gautier; Simon Ducheix; Alexandra Montagner; Arnaud Polizzi; Laurent Debrauwer; Hervé Guillou; Justine Bertrand-Michel; Cécile Canlet
Journal:  Metabolites       Date:  2019-12-21

3.  Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C: Optimizing the classification of intermediate fibrosis.

Authors:  Andrea Dória Batista; Carlos Jonnatan Pimentel Barros; Tássia Brena Barroso Carneiro Costa; Michele Maria Gonçalves de Godoy; Ronaldo Dionísio Silva; Joelma Carvalho Santos; Mariana Montenegro de Melo Lira; Norma Thomé Jucá; Edmundo Pessoa de Almeida Lopes; Ricardo Oliveira Silva
Journal:  World J Hepatol       Date:  2018-01-27

4.  Sugar Alcohols Have a Key Role in Pathogenesis of Chronic Liver Disease and Hepatocellular Carcinoma in Whole Blood and Liver Tissues.

Authors:  Israa T Ismail; Oliver Fiehn; Ashraf Elfert; Marwa Helal; Ibrahim Salama; Hala El-Said
Journal:  Cancers (Basel)       Date:  2020-02-19       Impact factor: 6.639
  4 in total

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