Literature DB >> 28412583

Metabolic reprograming of anti-tumor immunity.

Madhusudhanan Sukumar1, Rigel J Kishton2, Nicholas P Restifo3.   

Abstract

Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response - how T cells generate energy - plays an important role in their effectiveness. Furthermore the metabolism of T cells can be modulated to improve their anti-cancer activities. In this review, we will discuss the key metabolic properties of anti-cancer T cells, along with potential strategies to enhance immunotherapy through the modulation of T cell metabolism. Published by Elsevier Ltd.

Entities:  

Mesh：

Year:  2017        PMID： 28412583      PMCID： PMC6327315          DOI： 10.1016/j.coi.2017.03.011

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  61 in total

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Authors:  F Cardoso; Leo A Di; C Lohrisch; C Bernard; F Ferreira; M J Piccart
Journal:  Ann Oncol       Date:  2002-02       Impact factor: 32.976

Review 2.  Metastasis: a question of life or death.

Authors:  Patrick Mehlen; Alain Puisieux
Journal:  Nat Rev Cancer       Date:  2006-06       Impact factor: 60.716

3.  Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.

Authors:  Chance John Luckey; Deepta Bhattacharya; Ananda W Goldrath; Irving L Weissman; Christophe Benoist; Diane Mathis
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-21       Impact factor: 11.205

4.  Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.

Authors:  Keisuke Ito; Atsushi Hirao; Fumio Arai; Sahoko Matsuoka; Keiyo Takubo; Isao Hamaguchi; Kana Nomiyama; Kentaro Hosokawa; Kazuhiro Sakurada; Naomi Nakagata; Yasuo Ikeda; Tak W Mak; Toshio Suda
Journal:  Nature       Date:  2004-10-21       Impact factor: 49.962

5.  Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.

Authors:  Christopher A Klebanoff; Luca Gattinoni; Parizad Torabi-Parizi; Keith Kerstann; Adela R Cardones; Steven E Finkelstein; Douglas C Palmer; Paul A Antony; Sam T Hwang; Steven A Rosenberg; Thomas A Waldmann; Nicholas P Restifo
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-24       Impact factor: 11.205

6.  Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells.

Authors:  Yuichi Makino; Hiroshi Nakamura; Eiji Ikeda; Kei Ohnuma; Kenji Yamauchi; Yutaka Yabe; Lorenz Poellinger; Yasunori Okada; Chikao Morimoto; Hirotoshi Tanaka
Journal:  J Immunol       Date:  2003-12-15       Impact factor: 5.422

7.  Tumor-specific Th17-polarized cells eradicate large established melanoma.

Authors:  Pawel Muranski; Andrea Boni; Paul A Antony; Lydie Cassard; Kari R Irvine; Andrew Kaiser; Chrystal M Paulos; Douglas C Palmer; Christopher E Touloukian; Krzysztof Ptak; Luca Gattinoni; Claudia Wrzesinski; Christian S Hinrichs; Keith W Kerstann; Lionel Feigenbaum; Chi-Chao Chan; Nicholas P Restifo
Journal:  Blood       Date:  2008-03-19       Impact factor: 22.113

Review 8.  Adoptive cell transfer: a clinical path to effective cancer immunotherapy.

Authors:  Steven A Rosenberg; Nicholas P Restifo; James C Yang; Richard A Morgan; Mark E Dudley
Journal:  Nat Rev Cancer       Date:  2008-04       Impact factor: 60.716

Review 9.  Is HIF-1alpha a pro- or an anti-apoptotic protein?

Authors:  Jean-Pascal Piret; Denis Mottet; Martine Raes; Carine Michiels
Journal:  Biochem Pharmacol       Date:  2002-09       Impact factor: 5.858

10.  FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.

Authors:  Zuzana Tothova; Ramya Kollipara; Brian J Huntly; Benjamin H Lee; Diego H Castrillon; Dana E Cullen; Elizabeth P McDowell; Suzan Lazo-Kallanian; Ifor R Williams; Christopher Sears; Scott A Armstrong; Emmanuelle Passegué; Ronald A DePinho; D Gary Gilliland
Journal:  Cell       Date:  2007-01-26       Impact factor: 41.582
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  37 in total

1.  Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death.

Authors:  Tsadik Habtetsion; Zhi-Chun Ding; Wenhu Pi; Tao Li; Chunwan Lu; Tingting Chen; Caixia Xi; Helena Spartz; Kebin Liu; Zhonglin Hao; Nahid Mivechi; Yuqing Huo; Bruce R Blazar; David H Munn; Gang Zhou
Journal:  Cell Metab       Date:  2018-06-07       Impact factor: 27.287

Review 2.  Cancer Immunotherapy Getting Brainy: Visualizing the Distinctive CNS Metastatic Niche to Illuminate Therapeutic Resistance.

Authors:  Mark Owyong; Niloufar Hosseini-Nassab; Gizem Efe; Alexander Honkala; Renske J E van den Bijgaart; Vicki Plaks; Bryan Ronain Smith
Journal:  Drug Resist Updat       Date:  2017-10-14       Impact factor: 18.500

Review 3.  Therapeutic cancer vaccines.

Authors:  Mansi Saxena; Sjoerd H van der Burg; Cornelis J M Melief; Nina Bhardwaj
Journal:  Nat Rev Cancer       Date:  2021-04-27       Impact factor: 60.716

Review 4.  Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy.

Authors:  Rigel J Kishton; Madhusudhanan Sukumar; Nicholas P Restifo
Journal:  Cell Metab       Date:  2017-07-05       Impact factor: 27.287

Review 5.  Sculpting tumor microenvironment with immune system: from immunometabolism to immunoediting.

Authors:  Y-R Yu; P-C Ho
Journal:  Clin Exp Immunol       Date:  2019-04-01       Impact factor: 4.330

6.  Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function.

Authors:  Paramita Chakraborty; Rasesh Y Parikh; Seungho Choi; Danh Tran; Monika Gooz; Zachariah T Hedley; Do-Sung Kim; Dariusz Pytel; Inhong Kang; Satish N Nadig; Gyda C Beeson; Lauren Ball; Meenal Mehrotra; Hongjun Wang; Stefano Berto; Viswanathan Palanisamy; Hong Li; Shilpak Chatterjee; Paulo C Rodriguez; Eduardo N Maldonado; J Alan Diehl; Vamsi K Gangaraju; Shikhar Mehrotra
Journal:  Cancer Res       Date:  2022-05-16       Impact factor: 13.312

Review 7.  Functional genomics: paving the way for more successful cancer immunotherapy.

Authors:  Reham Ajina; Danielle Zamalin; Louis M Weiner
Journal:  Brief Funct Genomics       Date:  2019-03-22       Impact factor: 4.241

Review 8.  Antitumor T-cell Reconditioning: Improving Metabolic Fitness for Optimal Cancer Immunotherapy.

Authors:  Dayana B Rivadeneira; Greg M Delgoffe
Journal:  Clin Cancer Res       Date:  2018-01-31       Impact factor: 12.531

Review 9.  T-Cell Metabolism in Hematopoietic Cell Transplantation.

Authors:  Hung D Nguyen; Sandeepkumar Kuril; David Bastian; Xue-Zhong Yu
Journal:  Front Immunol       Date:  2018-02-09       Impact factor: 7.561

10.  Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells.

Authors:  Sonja Lieber; Silke Reinartz; Hartmann Raifer; Florian Finkernagel; Tobias Dreyer; Holger Bronger; Julia M Jansen; Uwe Wagner; Thomas Worzfeld; Rolf Müller; Magdalena Huber
Journal:  Oncoimmunology       Date:  2018-03-15       Impact factor: 8.110
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