Literature DB >> 28410655

Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease.

Bianca Gonzalez1, Edsel M Abud2, Abigail M Abud2, Wayne W Poon2, Karen H Gylys3.   

Abstract

To date, Alzheimer disease drug candidates have produced negative results in human trials, and progress in moving new targets out of the laboratory and into trials has been slow. However, based on 3 decades of previous work, there is reason to hope that amyloid-based and other novel therapies will move at a faster pace toward successful clinical trials. This article highlights selected preclinical research topics that are rapidly advancing in the laboratory.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cholesterol; Imaging flow cytometry; Microglia; Oligomer; Synapse

Mesh：

Substances：

Year:  2017        PMID： 28410655      PMCID： PMC5417853          DOI： 10.1016/j.ncl.2017.01.001

Source DB:  PubMed          Journal:  Neurol Clin        ISSN： 0733-8619            Impact factor:   3.806


  77 in total

1.  Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype.

Authors:  John M Ringman; David Elashoff; Daniel H Geschwind; Brian T Welsh; Karen H Gylys; Cathy Lee; Jeffrey L Cummings; Greg M Cole
Journal:  Arch Neurol       Date:  2012-06

2.  Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.

Authors:  R D Terry; E Masliah; D P Salmon; N Butters; R DeTeresa; R Hill; L A Hansen; R Katzman
Journal:  Ann Neurol       Date:  1991-10       Impact factor: 10.422

3.  Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease.

Authors:  Michael B Dinkins; Somsankar Dasgupta; Guanghu Wang; Gu Zhu; Erhard Bieberich
Journal:  Neurobiol Aging       Date:  2014-02-15       Impact factor: 4.673

4.  Depletion of microglia and inhibition of exosome synthesis halt tau propagation.

Authors:  Hirohide Asai; Seiko Ikezu; Satoshi Tsunoda; Maria Medalla; Jennifer Luebke; Tarik Haydar; Benjamin Wolozin; Oleg Butovsky; Sebastian Kügler; Tsuneya Ikezu
Journal:  Nat Neurosci       Date:  2015-10-05       Impact factor: 24.884

5.  Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease.

Authors:  Benoit Melchior; Angie E Garcia; Bor-Kai Hsiung; Katherine M Lo; Jonathan M Doose; J Cameron Thrash; Anna K Stalder; Matthias Staufenbiel; Harald Neumann; Monica J Carson
Journal:  ASN Neuro       Date:  2010-07-12       Impact factor: 4.146

Review 6.  Central nervous system: cholesterol turnover, brain development and neurodegeneration.

Authors:  John M Dietschy
Journal:  Biol Chem       Date:  2009-04       Impact factor: 3.915

Review 7.  Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.

Authors:  Sergio T Ferreira; Mychael V Lourenco; Mauricio M Oliveira; Fernanda G De Felice
Journal:  Front Cell Neurosci       Date:  2015-05-26       Impact factor: 5.505

8.  Non-Fibrillar Oligomeric Amyloid-β within Synapses.

Authors:  Eleanor K Pickett; Robert M Koffie; Susanne Wegmann; Christopher M Henstridge; Abigail G Herrmann; Marti Colom-Cadena; Alberto Lleo; Kevin R Kay; Melissa Vaught; Roy Soberman; Dominic M Walsh; Bradley T Hyman; Tara L Spires-Jones
Journal:  J Alzheimers Dis       Date:  2016-05-30       Impact factor: 4.472

9.  Missense variant in TREML2 protects against Alzheimer's disease.

Authors:  Bruno A Benitez; Sheng Chih Jin; Rita Guerreiro; Rob Graham; Jenny Lord; Denise Harold; Rebecca Sims; Jean-Charles Lambert; J Raphael Gibbs; Jose Bras; Celeste Sassi; Oscar Harari; Sarah Bertelsen; Michelle K Lupton; John Powell; Celine Bellenguez; Kristelle Brown; Christopher Medway; Patrick C G Haddick; Marcel P van der Brug; Tushar Bhangale; Ward Ortmann; Tim Behrens; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg; Jonathan L Haines; Jim Turton; Anne Braae; Imelda Barber; Anne M Fagan; David M Holtzman; John C Morris; Julie Williams; John S K Kauwe; Philippe Amouyel; Kevin Morgan; Andy Singleton; John Hardy; Alison M Goate; Carlos Cruchaga
Journal:  Neurobiol Aging       Date:  2013-12-21       Impact factor: 4.673

Review 10.  The amyloid hypothesis of Alzheimer's disease at 25 years.

Authors:  Dennis J Selkoe; John Hardy
Journal:  EMBO Mol Med       Date:  2016-06-01       Impact factor: 12.137
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  5 in total

1.  The short-term improvements of enriched environment in behaviors and pathological changes of APP/PS1 mice via regulating cytokines.

Authors:  Yuwei Zhang; Ge Wang; Lin Wang; Jian Zhao; Rui Huang; Qianying Xiong
Journal:  Hum Vaccin Immunother       Date:  2018-06-01       Impact factor: 3.452

2.  Telomere length and 8-hydroxy-2-deoxyguanosine as markers for early prediction of Alzheimer disease.

Authors:  Dalia H Abou-Elela; Rawhia H El-Edel; Amr S Shalaby; Mariam A Fouaad; Ahmed A Sonbol
Journal:  Indian J Psychiatry       Date:  2020-12-12       Impact factor: 1.759

Review 3.  Apolipoprotein E Epsilon 4 Genotype, Mild Traumatic Brain Injury, and the Development of Chronic Traumatic Encephalopathy.

Authors:  Hansen Deng; Angel Ordaz; Pavan S Upadhyayula; Eva M Gillis-Buck; Catherine G Suen; Caroline G Melhado; Nebil Mohammed; Troy Lam; John K Yue
Journal:  Med Sci (Basel)       Date:  2018-09-14

4.  (5R)-5-hydroxytriptolide inhibits the inflammatory cascade reaction in astrocytes.

Authors:  Yan-Qiu Cui; Yan Zheng; Gui-Lian Tan; Dong-Mei Zhang; Jun-Ya Wang; Xiao-Min Wang
Journal:  Neural Regen Res       Date:  2019-05       Impact factor: 5.135

5.  Protective effects of isoquercitrin on streptozotocin-induced neurotoxicity.

Authors:  Lei Chen; Peimin Feng; Anjiao Peng; Xiangmiao Qiu; Wanling Lai; Lin Zhang; Wanling Li
Journal:  J Cell Mol Med       Date:  2020-08-01       Impact factor: 5.310
  5 in total

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