Shohreh F Farzan1, Elizabeth B Brickley2, Zhigang Li2, Diane Gilbert-Diamond2, Anala Gossai2, Yu Chen3, Caitlin G Howe4, Thomas Palys2, Margaret R Karagas2. 1. Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address: sffarzan@usc.edu. 2. Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA and Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. 3. Department of Population Health, New York University School of Medicine, New York, NY, USA. 4. Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Abstract
INTRODUCTION: Accumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between prenatal As exposure and plasma biomarkers of inflammation and endothelial function in mothers and newborns are lacking. METHODS: We examined maternal urinary As levels at gestational weeks 24-28 and levels of inflammatory biomarkers in plasma from 563 pregnant women and 500 infants' cord blood. We assessed a multiplexed panel of circulating inflammatory and endothelial function markers, including tumor necrosis factor alpha (TNFα), monocyte chemoattractant protein 1 (MCP1), intercellular adhesion molecule (ICAM1) and vascular cell adhesion molecule (VCAM1). RESULTS: Compared with the bottom tertile, the highest tertile of maternal urinary As during pregnancy was associated with a 145.2ng/ml (95% CI 4.1, 286.3; p=0.04) increase in cord blood ICAM1 and 557.3ng/ml (95% CI -56.4, 1171.1; p=0.09) increase in cord blood VCAM1. Among mothers, the highest tertile of maternal urinary As during pregnancy was related to a 141.8ng/ml (95% CI 26.1, 257.5; p=0.02) increase maternal plasma VCAM1 levels. Urinary As was unrelated to MCP1 or TNFα in maternal plasma and cord blood. In structural equation models, the association between maternal urinary As and infant VCAM was mediated by maternal levels of VCAM (βmediation: 0.024, 95% CI: 0.002, 0.050). CONCLUSION: Our observations indicate that As exposure during pregnancy may affect markers of vascular health and endothelial function in both pregnant women and children, and suggest further investigation of the potential impacts on cardiovascular health in these susceptible populations.
INTRODUCTION: Accumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between prenatal As exposure and plasma biomarkers of inflammation and endothelial function in mothers and newborns are lacking. METHODS: We examined maternal urinary As levels at gestational weeks 24-28 and levels of inflammatory biomarkers in plasma from 563 pregnant women and 500 infants' cord blood. We assessed a multiplexed panel of circulating inflammatory and endothelial function markers, including tumor necrosis factor alpha (TNFα), monocyte chemoattractant protein 1 (MCP1), intercellular adhesion molecule (ICAM1) and vascular cell adhesion molecule (VCAM1). RESULTS: Compared with the bottom tertile, the highest tertile of maternal urinary As during pregnancy was associated with a 145.2ng/ml (95% CI 4.1, 286.3; p=0.04) increase in cord blood ICAM1 and 557.3ng/ml (95% CI -56.4, 1171.1; p=0.09) increase in cord blood VCAM1. Among mothers, the highest tertile of maternal urinary As during pregnancy was related to a 141.8ng/ml (95% CI 26.1, 257.5; p=0.02) increase maternal plasma VCAM1 levels. Urinary As was unrelated to MCP1 or TNFα in maternal plasma and cord blood. In structural equation models, the association between maternal urinary As and infant VCAM was mediated by maternal levels of VCAM (βmediation: 0.024, 95% CI: 0.002, 0.050). CONCLUSION: Our observations indicate that As exposure during pregnancy may affect markers of vascular health and endothelial function in both pregnant women and children, and suggest further investigation of the potential impacts on cardiovascular health in these susceptible populations.
Authors: Kathryn A Bailey; Jessica Laine; Julia E Rager; Elizabeth Sebastian; Andrew Olshan; Lisa Smeester; Zuzana Drobná; Miroslav Styblo; Marisela Rubio-Andrade; Gonzalo García-Vargas; Rebecca C Fry Journal: Toxicol Sci Date: 2014-03-27 Impact factor: 4.849
Authors: Julia E Rager; Kathryn A Bailey; Lisa Smeester; Sloane K Miller; Joel S Parker; Jessica E Laine; Zuzana Drobná; Jenna Currier; Christelle Douillet; Andrew F Olshan; Marisela Rubio-Andrade; Miroslav Stýblo; Gonzalo García-Vargas; Rebecca C Fry Journal: Environ Mol Mutagen Date: 2013-12-10 Impact factor: 3.216
Authors: Kathryn L Cottingham; Roxanne Karimi; Joann F Gruber; M Scot Zens; Vicki Sayarath; Carol L Folt; Tracy Punshon; J Steven Morris; Margaret R Karagas Journal: Nutr J Date: 2013-11-16 Impact factor: 3.271
Authors: Citlalli Osorio-Yáñez; Julio C Ayllon-Vergara; Guadalupe Aguilar-Madrid; Laura Arreola-Mendoza; Erika Hernández-Castellanos; Angel Barrera-Hernández; Andrea De Vizcaya-Ruiz; Luz M Del Razo Journal: Environ Health Perspect Date: 2013-06-11 Impact factor: 9.031
Authors: Paige A Bommarito; Elizabeth Martin; Lisa Smeester; Thomas Palys; Emily R Baker; Margaret R Karagas; Rebecca C Fry Journal: Reprod Toxicol Date: 2017-08-06 Impact factor: 3.143
Authors: Shohreh F Farzan; Hem Mahbubul Eunus; Syed Emdadul Haque; Golam Sarwar; Akm Rabiul Hasan; Fen Wu; Tariqul Islam; Alauddin Ahmed; Mohammad Shahriar; Farzana Jasmine; Muhammad G Kibriya; Faruque Parvez; Margaret R Karagas; Yu Chen; Habibul Ahsan Journal: Environ Res Date: 2022-01-08 Impact factor: 6.498
Authors: Gyeyoon Yim; Lorena Reynaga; Velia Nunez; Caitlin G Howe; Megan E Romano; Yu Chen; Margaret R Karagas; Claudia Toledo-Corral; Shohreh F Farzan Journal: Curr Environ Health Rep Date: 2022-08-18
Authors: Caitlin G Howe; Zhigang Li; Michael S Zens; Thomas Palys; Yu Chen; Jacqueline Y Channon; Margaret R Karagas; Shohreh F Farzan Journal: J Nutr Date: 2017-10-25 Impact factor: 4.798
Authors: Emily F Winterbottom; Yuka Moroishi; Yuliya Halchenko; David A Armstrong; Paul J Beach; Quang P Nguyen; Anthony J Capobianco; Nagi G Ayad; Carmen J Marsit; Zhigang Li; Margaret R Karagas; David J Robbins Journal: Environ Health Date: 2019-02-28 Impact factor: 5.984
Authors: Abee L Boyles; Brandiese E Beverly; Suzanne E Fenton; Chandra L Jackson; Anne Marie Z Jukic; Vicki L Sutherland; Donna D Baird; Gwen W Collman; Darlene Dixon; Kelly K Ferguson; Janet E Hall; Elizabeth M Martin; Thaddeus T Schug; Alexandra J White; Kelly J Chandler Journal: J Womens Health (Larchmt) Date: 2020-11-18 Impact factor: 2.681
Authors: Shohreh F Farzan; Caitlin G Howe; Michael S Zens; Thomas Palys; Jacqueline Y Channon; Zhigang Li; Yu Chen; Margaret R Karagas Journal: Environ Health Perspect Date: 2017-12-15 Impact factor: 9.031