Current research scenario for microcystins biodegradation - A review on fundamental knowledge, application prospects and challenges.

Microcystins (MCs) are common cyanotoxins produced by harmful cyanobacterial blooms (HCBs) and severely threaten human and ecosystems health. Biodegradation is an efficient and sustainable biological strategy for MCs removal. Many novel findings in fundamental knowledge and application potential of MC-biodegradation have been documented. Little effort has devoted to summarize and comment recent research progress on MC-biodegradation, and discuss the research problems and gaps. This review deals with current research scenario in aerobic and anaerobic biodegradation for MCs. Diverse organisms capable of degrading MCs are encapsulated. Enzymatic mechanisms and influence factors regulating aerobic and anaerobic MC-biodegradation are summarized and discussed, which are essential for assessing and reducing MC-risks during HCBs episodes. Also, we propose some ideas to solve the challenges and bottleneck problems in practical application of MC-biodegradation, and discuss research gaps and promising research methods which deserve special attention. This review may provide new insights on future direction of MC-biodegradation research, in order to further broaden its application prospects for bioremediation.