Literature DB >> 28407200

Adrenomedullin 2/intermedin: a putative drug candidate for treatment of cardiometabolic diseases.

Song-Yang Zhang1, Ming-Jiang Xu1, Xian Wang1.   

Abstract

Adrenomedullin (ADM) 2/intermedin (IMD) is a short peptide that belongs to the CGRP superfamily. Although it shares receptors with CGRP, ADM and amylin, ADM2 has significant and unique functions in the cardiovascular system. In the past decade, the cardiovascular effect of ADM2 has been carefully analysed. In this review, progress in understanding the effects of ADM2 on the cardiovascular system and its protective role in cardiometabolic diseases are summarized. LINKED ARTICLES: This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc.
© 2017 The British Pharmacological Society.

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Year:  2017        PMID： 28407200      PMCID： PMC5867024          DOI： 10.1111/bph.13814

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  98 in total

1.  Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats.

Authors:  S M Yang; J Liu; C X Li
Journal:  Genet Mol Res       Date:  2014-10-20

2.  Cardiovascular effects of newly discovered peptide intermedin/adrenomedullin 2.

Authors:  Chun-Shui Pan; Jing-Hui Yang; Da-Yong Cai; Jing Zhao; Helen Gerns; Jun Yang; Jaw-Kang Chang; Chao-Shu Tang; Yong-Fen Qi
Journal:  Peptides       Date:  2005-03-16       Impact factor: 3.750

Review 3.  Adrenomedullin 2/intermedin: a putative drug candidate for treatment of cardiometabolic diseases.

Authors:  Song-Yang Zhang; Ming-Jiang Xu; Xian Wang
Journal:  Br J Pharmacol       Date:  2017-05-16       Impact factor: 8.739

4.  Intracoronary intermedin 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin receptors and beta-adrenoreceptor-mediated nitric oxide release.

Authors:  Elena Grossini; Claudio Molinari; David A S G Mary; Francesca Uberti; Philippe Primo Caimmi; Giovanni Vacca
Journal:  J Appl Physiol (1985)       Date:  2009-08-20

5.  Intermedin (adrenomedullin2) stabilizes the endothelial barrier and antagonizes thrombin-induced barrier failure in endothelial cell monolayers.

Authors:  M Aslam; U Pfeil; D Gündüz; A Rafiq; W Kummer; H M Piper; T Noll
Journal:  Br J Pharmacol       Date:  2012-01       Impact factor: 8.739

6.  Adrenomedullin-2, a novel calcitonin/calcitonin-gene-related peptide family peptide, relaxes rat mesenteric artery: influence of pregnancy.

Authors:  Madhu Chauhan; Gracious R Ross; Uma Yallampalli; Chandra Yallampalli
Journal:  Endocrinology       Date:  2007-01-11       Impact factor: 4.736

7.  Adrenomedullin-2/intermedin induces cAMP accumulation in dissociated rat spinal cord cells: evidence for the existence of a distinct class of sites of action.

Authors:  Ali Akbar Owji; Jean-Guy Chabot; Yvan Dumont; Rémi Quirion
Journal:  J Mol Neurosci       Date:  2008-04-17       Impact factor: 3.444

8.  Intermedin is upregulated and has protective roles in a mouse ischemia/reperfusion model.

Authors:  Heng-Yu Zhang; Wei Jiang; Jian-Ying Liu; Yan Li; Chun-Lin Chen; Hong-Bo Xin; De-Jia Huang
Journal:  Hypertens Res       Date:  2009-08-14       Impact factor: 3.872

9.  Plasma levels of intermedin (adrenomedullin-2) in healthy human volunteers and patients with heart failure.

Authors:  David Bell; Brian J Gordon; Anita Lavery; Katie Megaw; Michael O Kinney; Mark T Harbinson
Journal:  Peptides       Date:  2016-01-06       Impact factor: 3.750

10.  Intermedin 1-53 inhibits rat cardiac fibroblast activation induced by angiotensin II.

Authors:  Jing Hui Yang; Yan Cai; Xiao Hui Duan; Cun Gen Ma; Xian Wang; Chao Shu Tang; Yong Fen Qi
Journal:  Regul Pept       Date:  2009-06-11
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  20 in total

Review 1.  Adrenomedullin 2/intermedin: a putative drug candidate for treatment of cardiometabolic diseases.

Authors:  Song-Yang Zhang; Ming-Jiang Xu; Xian Wang
Journal:  Br J Pharmacol       Date:  2017-05-16       Impact factor: 8.739

2.  Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.

Authors:  Andras Iring; Young-June Jin; Julián Albarrán-Juárez; Mauro Siragusa; ShengPeng Wang; Péter T Dancs; Akiko Nakayama; Sarah Tonack; Min Chen; Carsten Künne; Anna M Sokol; Stefan Günther; Alfredo Martínez; Ingrid Fleming; Nina Wettschureck; Johannes Graumann; Lee S Weinstein; Stefan Offermanns
Journal:  J Clin Invest       Date:  2019-06-17       Impact factor: 14.808

Review 3.  Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25.

Authors:  Debbie L Hay; Michael L Garelja; David R Poyner; Christopher S Walker
Journal:  Br J Pharmacol       Date:  2017-11-28       Impact factor: 8.739

4.  Spotlight on small molecules in cardiovascular diseases.

Authors:  Xin Wang; Yu Huang; Yong Ji
Journal:  Br J Pharmacol       Date:  2018-04       Impact factor: 8.739

5.  Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors.

Authors:  Michael L Garelja; Maggie Au; Margaret A Brimble; Joseph J Gingell; Erica R Hendrikse; Annie Lovell; Nicole Prodan; Patrick M Sexton; Andrew Siow; Christopher S Walker; Harriet A Watkins; Geoffrey M Williams; Denise Wootten; Sung H Yang; Paul W R Harris; Debbie L Hay
Journal:  ACS Pharmacol Transl Sci       Date:  2020-02-26

6.  Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.

Authors:  Yi-Lynn Liang; Matthew J Belousoff; Madeleine M Fletcher; Xin Zhang; Maryam Khoshouei; Giuseppe Deganutti; Cassandra Koole; Sebastian G B Furness; Laurence J Miller; Debbie L Hay; Arthur Christopoulos; Christopher A Reynolds; Radostin Danev; Denise Wootten; Patrick M Sexton
Journal:  ACS Pharmacol Transl Sci       Date:  2020-03-20

Review 7.  Fighting obesity by targeting factors regulating beige adipocytes.

Authors:  Allison E McQueen; Suneil K Koliwad; Jen-Chywan Wang
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2018-11       Impact factor: 4.294

8.  Neuroprotection of Intermedin Against Cerebral Ischemia/Reperfusion Injury Through Cerebral Microcirculation Improvement and Apoptosis Inhibition.

Authors:  Xin Guo; Jie Yuan; Meixi Li; Meng Wang; Peiyuan Lv
Journal:  J Mol Neurosci       Date:  2020-09-10       Impact factor: 3.444

9.  Biochemical characterization of G protein coupling to calcitonin gene-related peptide and adrenomedullin receptors using a native PAGE assay.

Authors:  Amanda M Roehrkasse; Margaret L Warner; Jason M Booe; Augen A Pioszak
Journal:  J Biol Chem       Date:  2020-06-02       Impact factor: 5.157

Review 10.  RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors.

Authors:  Augen A Pioszak; Debbie L Hay
Journal:  Adv Pharmacol       Date:  2020-01-27
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