Literature DB >> 28406888

Targeted protein degradation: You can glue it too!

Michal J Walczak1, Georg Petzold1, Nicolas H Thomä1.   

Abstract

Mesh：

Year:  2017        PMID： 28406888     DOI： 10.1038/nchembio.2355

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  9 in total

1.  Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation.

Authors:  K M Sakamoto; K B Kim; A Kumagai; F Mercurio; C M Crews; R J Deshaies
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

Review 2.  RING domain E3 ubiquitin ligases.

Authors:  Raymond J Deshaies; Claudio A P Joazeiro
Journal:  Annu Rev Biochem       Date:  2009       Impact factor: 23.643

3.  Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase.

Authors:  Georg Petzold; Eric S Fischer; Nicolas H Thomä
Journal:  Nature       Date:  2016-02-24       Impact factor: 49.962

4.  DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.

Authors:  Georg E Winter; Dennis L Buckley; Joshiawa Paulk; Justin M Roberts; Amanda Souza; Sirano Dhe-Paganon; James E Bradner
Journal:  Science       Date:  2015-05-21       Impact factor: 47.728

5.  Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

Authors:  Jing Lu; Yimin Qian; Martha Altieri; Hanqing Dong; Jing Wang; Kanak Raina; John Hines; James D Winkler; Andrew P Crew; Kevin Coleman; Craig M Crews
Journal:  Chem Biol       Date:  2015-06-04

Review 6.  Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.

Authors:  Takumi Ito; Hiroshi Handa
Journal:  Int J Hematol       Date:  2016-07-26       Impact factor: 2.490

Review 7.  SPLINTS: small-molecule protein ligand interface stabilizers.

Authors:  Eric S Fischer; Eunyoung Park; Michael J Eck; Nicolas H Thomä
Journal:  Curr Opin Struct Biol       Date:  2016-01-30       Impact factor: 6.809

8.  Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

Authors:  Michael Zengerle; Kwok-Ho Chan; Alessio Ciulli
Journal:  ACS Chem Biol       Date:  2015-06-16       Impact factor: 5.100

9.  Structural basis of PROTAC cooperative recognition for selective protein degradation.

Authors:  Morgan S Gadd; Andrea Testa; Xavier Lucas; Kwok-Ho Chan; Wenzhang Chen; Douglas J Lamont; Michael Zengerle; Alessio Ciulli
Journal:  Nat Chem Biol       Date:  2017-03-13       Impact factor: 15.040
  9 in total
  2 in total

Review 1.  PROTACs: great opportunities for academia and industry.

Authors:  Xiuyun Sun; Hongying Gao; Yiqing Yang; Ming He; Yue Wu; Yugang Song; Yan Tong; Yu Rao
Journal:  Signal Transduct Target Ther       Date:  2019-12-24

Review 2.  PROTACs: great opportunities for academia and industry.

Authors:  Xiuyun Sun; Hongying Gao; Yiqing Yang; Ming He; Yue Wu; Yugang Song; Yan Tong; Yu Rao
Journal:  Signal Transduct Target Ther       Date:  2019-12-24
  2 in total

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